Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7440.074 | uM | 0.02565 | 0.04838 | -0.9985 | -0.9930 | 1.7238 | 1.2828 | 0.9922 | 0.4778 | |
| HCC1419 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7440.074 | uM | 0.02565 | 0.04838 | -0.9985 | -0.9930 | 1.7238 | 1.2828 | 0.9922 | 0.4778 | |
| HCC1419 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7437.074 | uM | 0.03991 | 0.04961 | -0.9997 | -0.9835 | 5.0000 | 1.2451 | 0.9986 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7437.074 | uM | 0.03991 | 0.04961 | -0.9997 | -0.9835 | 5.0000 | 1.2451 | 0.9986 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12612.177 | uM | 0.27633 | 0.59194 | -0.9998 | -1.0000 | 1.4421 | 0.7563 | 0.9436 | 0.5119 | |
| HCC1419 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7820.011 | uM | 88.88780 | 144.89250 | -0.9365 | -0.9506 | 2.1798 | 0.3160 | 0.9953 | 0.6709 | |
| HCC1419 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10019.12 | uM | 43.09170 | 78.77850 | -0.9916 | -0.9762 | 1.7945 | 0.4068 | 0.9964 | 0.4898 | |
| HCC1419 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7819.075 | uM | 93.440 | 159.4530 | -0.9166 | -0.9434 | 1.9836 | 0.3035 | 0.9969 | 0.5386 | |
| HCC1419 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9278.011 | uM | 58.14860 | 105.43350 | -0.9721 | -0.9845 | 1.8287 | 0.3704 | 0.9976 | 0.5434 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7820.042 | uM | inf | inf | 1.0221 | 1.0221 | 0.0000 | -0.0483 | -28.6122 | 0.5216 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 10019.124 | uM | inf | inf | 0.9810 | 0.9810 | 0.0000 | -0.0457 | -3.7312 | 0.5356 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7818.018 | uM | inf | inf | 0.8205 | 0.8205 | 0.0000 | 0.1029 | -0.1580 | 0.9928 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7821.042 | uM | inf | inf | 0.7843 | 0.7843 | 0.0000 | 0.1193 | -0.0824 | 0.5522 | |
| HCC1419 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 9278.026 | uM | inf | inf | 0.8659 | 0.8659 | 0.0000 | 0.0594 | -0.0671 | 0.3395 | |
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7818.018 | uM | 43.14510 | 395.0930 | -0.9231 | -1.0000 | 0.4961 | 0.5311 | 0.8727 | 0.9928 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 10019.124 | uM | 6.80690 | 30.23160 | -0.9945 | -1.0000 | 0.7369 | 0.5217 | 0.9114 | 0.5356 | ||
| HCC1419 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 9278.026 | uM | 1.04710 | 16.32940 | -1.0000 | -1.0000 | 0.3999 | 0.9084 | 0.9403 | 0.3395 | ||
| HCC1419 | HER2amp | Luminal | Chloroquine | 12612.177 | uM | 3.48190 | 13.34580 | -0.8059 | -1.0000 | 0.8177 | 0.4240 | 0.8498 | 0.5119 | |||
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10019.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0250 | -0.1954 | 0.4626 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7820.017 | uM | 7.99380 | 16.98340 | -0.9572 | -0.9743 | 1.4350 | 0.4528 | 0.9802 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9278.017 | uM | 11.51060 | 25.01950 | -0.9897 | -1.0000 | 1.4150 | 0.3506 | 0.9950 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7821.017 | uM | 10.94250 | 15.93540 | -0.9918 | -0.9887 | 2.9026 | 0.4020 | 0.9954 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7821.007 | uM | 8.44820 | 29.69020 | -0.4350 | -1.0000 | 0.8741 | 0.3180 | 0.8791 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 9278.121 | uM | 22.31750 | 45.79590 | -0.4534 | -1.0000 | 1.5283 | 0.1211 | 0.9825 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7820.007 | uM | 20.30050 | 23.53010 | -0.4963 | -0.5031 | 4.7162 | 0.0753 | 0.9929 | 0.6838 |