Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9278.132 | uM | inf | inf | 0.8317 | 0.8317 | 0.0000 | 0.2719 | 0.0075 | 0.3815 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7821.016 | uM | inf | inf | 0.6910 | 0.6910 | 0.0000 | 0.1510 | 0.2609 | 0.3100 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7820.016 | uM | inf | inf | -0.0021 | -0.0021 | 0.0000 | 0.2345 | 0.5325 | 0.4466 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7819.016 | uM | 9.71070 | 8.41250 | -0.1469 | 0.2560 | 5.0000 | 0.2066 | 0.6772 | 0.5331 | ||
| HCC1419 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7818.016 | uM | 23.49420 | 82.24970 | -0.3848 | -1.0000 | 0.8768 | 0.2679 | 0.9123 | 0.9146 | ||
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7818.05 | uM | 0.03477 | 0.11695 | -0.9195 | -0.7107 | 0.7290 | 0.8927 | 0.9440 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7820.05 | uM | 0.09953 | 0.12156 | -0.9970 | -0.8586 | 5.0000 | 1.0211 | 0.9799 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7820.04 | uM | 0.09847 | 0.20649 | -0.7923 | -0.7095 | 1.1929 | 0.8298 | 0.9851 | 0.7382 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7821.05 | uM | 0.04804 | 0.06835 | -0.9999 | -0.9295 | 2.9796 | 1.0943 | 0.9946 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 10019.037 | uM | 0.08594 | 0.10557 | -0.9986 | -0.8989 | 5.0000 | 1.0136 | 0.9958 | 0.4232 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9278.037 | uM | 0.02447 | 0.03619 | -0.9993 | -0.9737 | 2.7625 | 1.1989 | 0.9991 | 0.3822 | |
| HCC1419 | HER2amp | Luminal | 2-deoxyglucose | 12612.177 | uM | 88.93330 | 1000.00000 | -0.0200 | -0.4328 | 0.2577 | 0.3557 | 0.6693 | 0.5119 | |||
| HCC1419 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12001.143 | uM | 815.0230 | 1000.00000 | 0.1551 | -0.0348 | 0.3288 | 0.2369 | 0.7161 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7820.017 | uM | 127.9330 | 620.18530 | -0.7617 | -0.9506 | 0.6748 | 0.5583 | 0.9859 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9278.017 | uM | 202.71430 | 410.73390 | -0.8238 | -0.7855 | 1.3373 | 0.5490 | 0.9899 | 0.5453 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7821.017 | uM | 232.84290 | 534.85860 | -0.8970 | -0.8996 | 1.2377 | 0.4969 | 0.9956 | 0.3792 | |
| HCC1419 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12001.165 | uM | 0.00364 | 0.01397 | -0.9997 | -0.9330 | 0.7834 | 1.2629 | 0.9922 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7440.066 | uM | inf | inf | 0.7221 | 0.7221 | 0.0000 | 0.0385 | 0.4442 | 0.4073 | |
| HCC1419 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7437.066 | uM | 6.67690 | 7.37020 | -0.3186 | -0.3193 | 5.0000 | 0.1549 | 0.9662 | 0.3525 | |
| HCC1419 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7820.016 | uM | 1.29380 | 1.4090 | -0.5449 | -0.2660 | 5.0000 | 0.4935 | 0.8958 | 0.4466 | |
| HCC1419 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7821.016 | uM | 0.87254 | 1.1560 | -0.3806 | -0.4291 | 2.2024 | 0.5987 | 0.9512 | 0.3100 | |
| HCC1419 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7819.016 | uM | 1.10530 | 3.0260 | -0.8634 | -0.9047 | 1.0257 | 0.6229 | 0.9747 | 0.5331 | |
| HCC1419 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7818.016 | uM | 2.12830 | 6.66280 | -0.9514 | -1.0000 | 0.9627 | 0.5655 | 0.9839 | 0.9146 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 12001.165 | uM | 19.75040 | 223.90360 | 0.3866 | -1.0000 | 0.4525 | 0.1627 | 0.7229 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 7437.073 | uM | 146.82210 | 170.80150 | 0.2612 | -0.5653 | 5.0000 | 0.0246 | 0.9617 | 0.4617 |