Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12084.16 | uM | 10.48610 | 16.43240 | -0.7022 | -1.0000 | 2.4457 | 0.1867 | 0.9535 | 1.1178 | |
| HCC1395 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 7436.093 | uM | 5.77340 | 6.84120 | -0.1695 | -0.1853 | 1.8577 | 0.1887 | 0.9946 | 1.2596 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 7813.012 | uM | inf | inf | 0.3285 | 0.3285 | 0.0000 | 0.3675 | 0.4050 | 1.0493 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 7813.036 | uM | 0.26140 | 0.12168 | 0.2979 | 0.4246 | 2.4735 | 0.2220 | 0.9020 | 0.8030 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 7814.036 | uM | 0.15444 | 0.05430 | 0.1940 | 0.3309 | 1.0373 | 0.3079 | 0.9107 | 0.8168 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 9258.024 | uM | 0.15467 | 0.14061 | -0.0098 | 0.1087 | 2.5731 | 0.3439 | 0.9190 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 7816.05 | uM | 0.27758 | 0.07909 | 0.4140 | 0.4453 | 1.7616 | 0.2230 | 0.9770 | 1.0200 | |
| HCC1395 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9258.026 | uM | inf | inf | 0.5784 | 0.5784 | 0.0000 | 0.1398 | 0.2126 | 0.5632 | |
| HCC1395 | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9254.124 | uM | inf | inf | 0.8784 | 0.8784 | 0.0000 | -0.0335 | 0.3867 | 0.8067 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7435.065 | uM | 16.10720 | 23.80130 | -0.9606 | -0.8780 | 2.5962 | 0.8678 | 0.9228 | 0.8513 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7436.065 | uM | 33.8530 | 69.90340 | -0.8645 | -0.8217 | 1.3406 | 0.5995 | 0.9984 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Triciribine | AKT | AKT | 7436.074 | uM | 0.41114 | 0.29583 | 0.4261 | 0.4036 | 5.0000 | 0.2456 | 0.8137 | 1.2173 | |
| HCC1395 | TNBC | Basal B | Triciribine | AKT | AKT | 7435.074 | uM | 1.38020 | 37.05640 | 0.1032 | -0.8302 | 0.2974 | 0.3180 | 0.9201 | 0.8579 | |
| HCC1395 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 12084.143 | uM | inf | inf | -0.3199 | -0.3199 | 0.0000 | 0.1782 | 0.5662 | 1.3499 | |
| HCC1395 | TNBC | Basal B | Valproic acid | HDAC | HDAC | 12000.143 | uM | 651.12270 | 1000.00000 | -0.4587 | -0.1990 | 0.7808 | 0.3217 | 0.5906 | 0.8939 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7813.018 | uM | 0.00024 | 0.00082 | -0.9987 | -0.8558 | 0.8040 | 1.5321 | 0.9392 | 0.8420 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7814.042 | uM | 0.00326 | 0.00560 | -0.9897 | -0.8260 | 1.8086 | 1.2937 | 0.9791 | 0.8414 | |
| HCC1395 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7816.042 | uM | 0.00742 | 0.00981 | -0.9736 | -0.7383 | 3.2478 | 1.1471 | 0.9833 | 0.9332 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7435.065 | uM | 248.62950 | 534.17570 | -0.8350 | -0.8664 | 1.3145 | 0.5484 | 0.9815 | 0.8513 | |
| HCC1395 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7436.065 | uM | 329.03280 | 638.92750 | -0.7212 | -0.7007 | 1.3201 | 0.4320 | 0.9942 | 1.2177 | |
| HCC1395 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 12084.157 | uM | 1.33230 | 1.0830 | 0.3667 | 0.3225 | 5.0000 | 0.2732 | 0.8875 | 1.3475 | |
| HCC1395 | TNBC | Basal B | XRP44X | ELK3 | MAPK | 12000.157 | uM | 0.75256 | 0.91091 | -0.3929 | -0.3073 | 2.5087 | 0.5433 | 0.9677 | 0.7671 | |
| HCC1395 | TNBC | Basal B | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14239.189 | uM | 0.60168 | 0.68836 | -0.7910 | -0.4800 | 5.0000 | 0.6158 | 0.8963 | 0.8223 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12084.16 | uM | 10.36280 | 49.94910 | -0.3937 | -1.0000 | 0.6985 | 0.2339 | 0.8776 | 1.1178 | |
| HCC1395 | TNBC | Basal B | ZM-447439 | AURK | AURK | 12000.169 | uM | 1.98770 | 4.28150 | -0.8539 | -0.9196 | 1.3600 | 0.4011 | 0.9959 | 0.8565 |