Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9294.012 | uM | 0.03556 | 0.04427 | -0.2393 | -0.2036 | 1.5590 | 0.7136 | 0.9988 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9294.011 | uM | 30.74820 | 25.37860 | 0.3087 | 0.3085 | 4.9997 | 0.1076 | 0.9225 | 0.7255 | |
| HCC1428 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 11936.16 | uM | inf | inf | 0.5428 | 0.5428 | 0.0000 | 0.1994 | 0.3339 | 0.8962 | ||
| HCC1428 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10693.15 | uM | inf | 3.06680 | 0.7873 | 0.8241 | 4.6548 | 0.0279 | 0.6672 | 0.7763 | ||
| HCC1428 | HR+ | Luminal | GM6001 | MMP | MMP | 7442.096 | uM | inf | inf | 0.8382 | 0.8382 | 0.0000 | 0.0600 | 0.4018 | 0.7665 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 10031.001 | uM | 6.51590 | 11.98480 | -0.7686 | -1.0000 | 1.8028 | 0.2433 | 0.9591 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9294.001 | uM | 1.30710 | 4.36920 | -0.9528 | -1.0000 | 0.9104 | 0.3850 | 0.9647 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7442.098 | uM | 3.32550 | 3.65460 | -0.9197 | -0.3015 | 5.0000 | 0.3344 | 0.7482 | 0.8652 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7441.09 | uM | 1.24390 | 1.35480 | -0.4627 | -0.2663 | 5.0000 | 0.4496 | 0.8842 | 0.7331 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7443.09 | uM | 1.3110 | 1.34350 | -0.2507 | -0.0652 | 5.0000 | 0.3593 | 0.8966 | 0.9451 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7442.092 | uM | 2.32010 | 2.73050 | -0.9877 | -0.6288 | 5.0000 | 0.4894 | 0.9104 | 0.7831 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7444.098 | uM | 0.68095 | 1.03960 | -0.7494 | -0.5163 | 1.6763 | 0.5832 | 0.9309 | 0.9681 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7444.071 | uM | 2.80680 | 5.61420 | -0.9802 | -1.0000 | 1.5847 | 0.5165 | 0.9817 | 0.8133 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7443.07 | uM | 1.79960 | 3.39080 | -0.9691 | -1.0000 | 1.7342 | 0.5217 | 0.9823 | 0.9389 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7444.091 | uM | 0.98199 | 6.60660 | -0.7818 | -1.0000 | 0.5763 | 0.4974 | 0.9829 | 0.8764 | |
| HCC1428 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7443.098 | uM | 1.92730 | 3.53910 | -0.9715 | -1.0000 | 1.8077 | 0.5173 | 0.9836 | 0.9189 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9294.001 | uM | 3.17740 | 8.92350 | -0.6549 | -1.0000 | 1.0639 | 0.3056 | 0.9387 | 0.7859 | |
| HCC1428 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10031.001 | uM | 7.23950 | 9.99140 | -0.9807 | -1.0000 | 3.4100 | 0.2079 | 0.980 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 10031.001 | uM | 8.70410 | 17.26910 | -0.4989 | -1.0000 | 1.6035 | 0.2417 | 0.8704 | 0.8981 | |
| HCC1428 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9294.001 | uM | 1.09240 | 9.7290 | -0.5557 | -1.0000 | 0.5024 | 0.3293 | 0.8740 | 0.7859 | |
| HCC1428 | HR+ | Luminal | Ibandronate | FDPS | 11936.143 | uM | 99.46520 | 174.74150 | -0.2835 | -0.4130 | 1.0685 | 0.2635 | 0.9839 | 0.7979 | ||
| HCC1428 | HR+ | Luminal | Ibandronate | FDPS | 10693.143 | uM | 128.80680 | 161.4630 | -0.2755 | -0.2893 | 2.0206 | 0.2223 | 0.9979 | 0.7509 | ||
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 11936.157 | uM | inf | inf | 0.7052 | 0.7052 | 0.0000 | 0.1856 | -0.0376 | 0.9133 | |
| HCC1428 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10693.151 | uM | inf | inf | 0.8929 | 0.8929 | 0.0000 | 0.0509 | 0.1105 | 0.9475 | |
| HCC1428 | HR+ | Luminal | IKK16 | IKK | NFKB | 10441.093 | uM | 3.19980 | 4.05180 | -0.9656 | -0.9674 | 4.5605 | 0.4517 | 0.9924 | 1.1458 |