Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 9233.002 | uM | 0.01724 | 0.01845 | -0.1472 | -0.2018 | 4.9997 | 0.5924 | 0.9660 | 0.9358 | |
| HCC1143 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7810.002 | uM | 0.00412 | 0.00608 | -0.2888 | -0.2655 | 1.0948 | 0.7382 | 0.9669 | 1.1625 | |
| HCC1143 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 9233.121 | uM | 0.23336 | 0.58881 | -0.9209 | -0.8258 | 1.0537 | 0.7010 | 0.9918 | 0.9468 | |
| HCC1143 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7810.007 | uM | 0.47212 | 0.57511 | -0.9538 | -0.8410 | 5.0000 | 0.7108 | 0.9954 | 0.9616 | |
| HCC1143 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7809.017 | uM | 0.16457 | 0.65415 | -0.9582 | -0.8345 | 0.7114 | 0.7917 | 0.9710 | 1.7591 | |
| HCC1143 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7810.017 | uM | 0.36613 | 0.54129 | -0.9998 | -0.8995 | 2.6326 | 0.8182 | 0.9965 | 0.8986 | |
| HCC1143 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7430.091 | uM | 91.99970 | 35.51210 | 0.5411 | 0.2413 | 0.6921 | 0.0640 | 0.9318 | 1.7667 | |
| HCC1143 | TNBC | Basal A | Etoposide | TOP2 | TOP | 7430.074 | uM | 6.14930 | 15.20170 | -0.4426 | -0.5494 | 0.8191 | 0.3723 | 0.9968 | 1.6943 | |
| HCC1143 | TNBC | Basal A | Everolimus | MTOR | MTOR | 12112.164 | uM | 3.27530 | 20.7090 | -0.6745 | -1.0000 | 0.5957 | 0.3644 | 0.7628 | 1.9275 | |
| HCC1143 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7430.085 | uM | 0.31162 | 0.48073 | -0.8868 | -0.8580 | 2.3047 | 0.6072 | 0.9972 | 1.9592 | |
| HCC1143 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 12112.161 | uM | 95.97580 | 456.18670 | 0.4862 | -1.0000 | 0.7048 | 0.1069 | 0.7799 | 1.7182 | |
| HCC1143 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 12112.154 | uM | inf | inf | 0.8713 | 0.8713 | 0.0000 | 0.0797 | -0.0472 | 1.8321 | |
| HCC1143 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 9233.049 | uM | inf | 8.98950 | 0.7384 | 0.6348 | 0.6252 | 0.0395 | 0.8403 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7809.016 | uM | 11.17440 | 51.71960 | 0.1136 | -1.0000 | 0.7170 | 0.1689 | 0.8712 | 1.6622 | |
| HCC1143 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7810.016 | uM | 7.79570 | 9.10660 | 0.0537 | -0.1148 | 1.3297 | 0.1171 | 0.9833 | 0.9032 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 9233.049 | uM | 0.11132 | 0.12087 | -0.1985 | -0.2545 | 5.0000 | 0.6576 | 0.9923 | 1.0911 | |
| HCC1143 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7810.012 | uM | 0.05388 | 0.06177 | -0.2822 | -0.2227 | 2.6971 | 0.6873 | 0.9964 | 0.9298 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 9233.12 | uM | 0.01453 | 0.01483 | -0.1546 | -0.0524 | 5.0000 | 0.6951 | 0.9750 | 1.1442 | |
| HCC1143 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7810.011 | uM | 0.00704 | 0.00710 | -0.1045 | -0.0221 | 4.9999 | 0.7914 | 0.9757 | 0.9243 | |
| HCC1143 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 12112.16 | uM | 13.0250 | 4.55930 | 0.3445 | 0.2984 | 0.8653 | 0.1600 | 0.9739 | 1.7073 | ||
| HCC1143 | TNBC | Basal A | GM6001 | MMP | MMP | 7430.096 | uM | inf | 999.99930 | 0.8237 | 0.5783 | 0.1530 | 0.0823 | 0.6514 | 2.0162 | |
| HCC1143 | TNBC | Basal A | GSK1070916 | AURK | AURK | 9233.001 | uM | 3.20110 | 8.78260 | -0.8187 | -1.0000 | 1.0885 | 0.3233 | 0.9120 | 0.9839 | |
| HCC1143 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7810.001 | uM | 1.93580 | 6.36580 | -0.8483 | -1.0000 | 0.9229 | 0.3410 | 0.9271 | 0.9063 | |
| HCC1143 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7430.098 | uM | 3.22180 | 2.84250 | 0.0714 | 0.2328 | 5.0000 | 0.1954 | 0.9402 | 1.9267 | |
| HCC1143 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7430.091 | uM | 3.05210 | 6.80580 | -0.8432 | -0.9663 | 1.3416 | 0.4548 | 0.9821 | 1.7667 |