Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5911.07 | uM | 4.05650 | 5.22440 | -0.8899 | -0.8904 | 4.0421 | 0.4268 | 0.9876 | 1.0709 | |
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5912.071 | uM | 5.42810 | 7.09740 | -0.8936 | -0.8940 | 3.8239 | 0.4468 | 0.9919 | 1.2176 | |
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5912.091 | uM | 63.76570 | 79.43490 | -0.8625 | -1.0000 | 5.0000 | 0.0778 | 0.9950 | 1.0917 | |
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5911.098 | uM | 4.01970 | 4.92020 | -0.8704 | -0.8709 | 4.9895 | 0.3801 | 0.9976 | 1.0659 | |
| CAMA-1 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9210.001 | uM | inf | inf | -0.8377 | -0.8377 | 0.0000 | 0.3922 | 0.4054 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9210.001 | uM | 0.04176 | 0.04248 | 0.0422 | -0.0444 | 5.0000 | 0.5720 | 0.9668 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GW843682X | PLK | PLK | 10473.139 | uM | inf | inf | 0.8203 | 0.8203 | 0.0000 | 0.0378 | 0.4564 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | Ibandronate | FDPS | 10755.143 | uM | 93.02980 | 186.9680 | -0.7925 | -0.8809 | 1.4554 | 0.3745 | 0.9695 | 0.9034 | ||
| CAMA-1 | HR+ | Luminal | Ibandronate | FDPS | 12070.143 | uM | 209.3390 | 252.68780 | -0.7810 | -0.7813 | 5.0000 | 0.2384 | 0.9969 | 0.9561 | ||
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10473.139 | uM | inf | inf | 0.6716 | 0.6716 | 0.0000 | 0.1245 | 0.5717 | 1.2054 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10755.151 | uM | inf | 1000.00000 | 0.5632 | -0.0574 | 0.1633 | 0.1928 | 0.6976 | 0.6846 | |
| CAMA-1 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12070.157 | uM | inf | 999.99560 | 0.6864 | -0.0060 | 0.2470 | 0.1210 | 0.7266 | 1.2286 | |
| CAMA-1 | HR+ | Luminal | IKK16 | IKK | NFKB | 10473.1 | uM | 2.7750 | 3.98670 | -0.9480 | -0.9578 | 2.9534 | 0.4647 | 0.9903 | 1.3652 | |
| CAMA-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5911.09 | uM | 16.59840 | 25.68660 | -0.9710 | -0.9922 | 2.5040 | 0.5143 | 0.9962 | 1.1067 | |
| CAMA-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5912.091 | uM | 21.42560 | 28.67010 | -0.9748 | -0.9689 | 3.6999 | 0.4290 | 0.9992 | 1.0917 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 5911.067 | uM | 0.02033 | 0.02637 | -0.9872 | -0.6904 | 3.3365 | 0.9284 | 0.9783 | 1.0037 | |
| CAMA-1 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 5912.067 | uM | 0.02378 | 0.02998 | -0.9731 | -0.7247 | 3.8640 | 0.9588 | 0.9791 | 1.1725 | |
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5911.094 | uM | 0.00116 | 0.00147 | -0.9872 | -0.4078 | 2.5090 | 1.3193 | 0.6376 | 1.0146 | |
| CAMA-1 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5912.095 | uM | 0.00065 | 0.00095 | -0.9867 | -0.7402 | 2.3688 | 1.4206 | 0.9535 | 0.9981 | |
| CAMA-1 | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12070.144 | uM | 1.9260 | 1.96060 | -0.0407 | -0.0466 | 4.9959 | 0.3246 | 0.7174 | 1.1742 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10755.149 | uM | inf | inf | 0.5042 | 0.5042 | 0.0000 | 0.1360 | 0.3490 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 10473.137 | uM | inf | inf | 0.8531 | 0.8531 | 0.0000 | -0.0131 | 0.5134 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | L-779450 | BRAF | MAPK | 12070.161 | uM | 33.99540 | 42.07970 | -0.3731 | -0.9527 | 4.9994 | 0.1100 | 0.9712 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 5911.098 | uM | inf | inf | 0.9203 | 0.9203 | 0.0000 | 0.0402 | -0.1673 | 1.0659 | |
| CAMA-1 | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 5912.098 | uM | inf | inf | 0.9364 | 0.9364 | 0.0000 | 0.0254 | -0.0141 | 1.0559 |