Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 10755.154 | uM | 0.07736 | 0.10646 | -0.7830 | -0.7740 | 2.9289 | 0.8509 | 0.9836 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | LBH589 | HDAC | HDAC | 12070.154 | uM | 0.02363 | 0.03825 | -0.9008 | -0.9318 | 2.1846 | 1.0139 | 0.9977 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12070.154 | uM | 0.61156 | 2.67570 | -0.9477 | -1.0000 | 0.7443 | 0.4513 | 0.8951 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10755.154 | uM | 3.98270 | 7.35970 | -0.9711 | -1.0000 | 1.7891 | 0.3690 | 0.9281 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10473.142 | uM | 5.70560 | 9.9930 | -0.9793 | -0.9990 | 1.9591 | 0.3434 | 0.9972 | 1.0815 | |
| CAMA-1 | HR+ | Luminal | Mebendazole | 12647.174 | uM | 0.27826 | 0.32199 | -0.1234 | -0.1133 | 1.3989 | 0.5322 | 0.9148 | 0.9362 | |||
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 5912.084 | uM | 0.03731 | 0.02696 | 0.2552 | 0.4014 | 5.0000 | 0.4338 | 0.8849 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 5911.084 | uM | 0.12725 | 0.03793 | 0.3744 | 0.4359 | 1.6963 | 0.4007 | 0.9682 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Methylglyoxal | 13157.184 | uM | 532.38820 | 1000.00000 | -0.9916 | -0.5508 | 1.1782 | 0.3945 | 0.8666 | 0.8492 | |||
| CAMA-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14236.189 | uM | inf | inf | -0.9745 | -0.9745 | 0.0000 | 0.7528 | 0.5730 | 0.8534 | |
| CAMA-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14236.189 | uM | inf | inf | -0.9745 | -0.9745 | 0.0000 | 0.7528 | 0.5730 | 0.8534 | |
| CAMA-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10755.145 | uM | 0.17218 | 0.25004 | -0.9524 | -0.9359 | 2.8275 | 0.8894 | 0.990 | 0.7688 | |
| CAMA-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10755.145 | uM | 0.17218 | 0.25004 | -0.9524 | -0.9359 | 2.8275 | 0.8894 | 0.990 | 0.7688 | |
| CAMA-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12070.145 | uM | 0.14703 | 0.19786 | -0.9737 | -0.9683 | 3.6284 | 0.9299 | 0.9912 | 1.0737 | |
| CAMA-1 | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 12070.145 | uM | 0.14703 | 0.19786 | -0.9737 | -0.9683 | 3.6284 | 0.9299 | 0.9912 | 1.0737 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 10755.148 | uM | 0.01695 | 0.04893 | -0.4561 | -0.5124 | 0.6654 | 0.8774 | 0.9432 | 0.6379 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 12070.135 | uM | 0.04376 | 0.04473 | -0.0895 | -0.0173 | 1.5605 | 0.6129 | 0.9556 | 1.2457 | |
| CAMA-1 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 10473.135 | uM | 0.11216 | 0.11292 | -0.0175 | -0.0172 | 5.0000 | 0.5117 | 0.9922 | 1.1592 | |
| CAMA-1 | HR+ | Luminal | Nelfinavir | 12647.174 | uM | 4.63860 | 8.64280 | -0.9213 | -1.0000 | 1.7654 | 0.3605 | 0.8914 | 0.9362 | |||
| CAMA-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12070.145 | uM | inf | inf | 0.8990 | 0.8990 | 0.0000 | 0.1345 | 0.0301 | 1.0737 | |
| CAMA-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 10755.145 | uM | inf | inf | 0.9059 | 0.9059 | 0.0000 | 0.0960 | 0.1467 | 0.7688 | |
| CAMA-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10755.152 | uM | 1.8650 | 2.76950 | -0.9988 | -1.0000 | 2.7783 | 0.7200 | 0.9787 | 0.5859 | |
| CAMA-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12070.159 | uM | 2.01710 | 2.54470 | -0.9763 | -0.9749 | 4.6561 | 0.6449 | 0.9948 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10473.14 | uM | 2.43380 | 4.24210 | -0.9447 | -0.9624 | 1.9316 | 0.5953 | 0.9964 | 1.3126 | |
| CAMA-1 | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 12070.147 | uM | 12.58410 | 15.26170 | -0.8106 | -0.8118 | 4.9998 | 0.2890 | 0.9010 | 0.9269 |