Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9210.121 | uM | 0.24804 | 0.37643 | -0.9940 | -0.9511 | 2.5542 | 0.8267 | 0.9980 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 5912.091 | uM | inf | inf | 0.9326 | 0.9326 | 0.0000 | -0.0358 | -0.2923 | 1.0917 | |
| CAMA-1 | HR+ | Luminal | Erlotinib | EGFR | ErbB | 5911.09 | uM | inf | 999.61920 | 0.7465 | -0.0042 | 0.4153 | 0.0587 | 0.7576 | 1.1067 | |
| CAMA-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 5911.074 | uM | 2.52280 | 10.37220 | -0.3484 | -0.6117 | 0.5652 | 0.5083 | 0.9487 | 1.1317 | |
| CAMA-1 | HR+ | Luminal | Etoposide | TOP2 | TOP | 5912.074 | uM | 5.46690 | 8.61420 | -0.5207 | -0.5006 | 1.5256 | 0.4347 | 0.9946 | 0.9249 | |
| CAMA-1 | HR+ | Luminal | Everolimus | MTOR | MTOR | 12070.164 | uM | 0.00797 | 0.02807 | -0.8032 | -0.5472 | 0.5870 | 0.8995 | 0.9525 | 1.2068 | |
| CAMA-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 5911.084 | uM | 0.25654 | 0.35180 | -0.9865 | -0.9895 | 3.4566 | 0.7079 | 0.9980 | 1.0262 | |
| CAMA-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 5912.084 | uM | 0.26223 | 0.35486 | -0.9745 | -0.9787 | 3.5844 | 0.6806 | 0.9984 | 1.0966 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12070.161 | uM | inf | inf | 0.8208 | 0.8208 | 0.0000 | 0.0972 | -0.1231 | 1.2903 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10755.149 | uM | inf | inf | 0.8927 | 0.8927 | 0.0000 | 0.1628 | -0.1038 | 0.9687 | |
| CAMA-1 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 10473.137 | uM | inf | inf | 0.9840 | 0.9840 | 0.0000 | 0.0297 | -0.0565 | 1.1322 | |
| CAMA-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10755.154 | uM | inf | inf | 0.8328 | 0.8328 | 0.0000 | 0.1445 | -0.2770 | 1.0198 | |
| CAMA-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 10473.142 | uM | inf | inf | 0.9428 | 0.9428 | 0.0000 | 0.0415 | -0.0641 | 1.0815 | |
| CAMA-1 | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12070.154 | uM | inf | inf | 0.8347 | 0.8347 | 0.0000 | 0.0945 | 0.2480 | 1.1006 | |
| CAMA-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9210.024 | uM | 12.35690 | 11.57250 | 0.1404 | 0.1350 | 4.8005 | 0.0791 | 0.8743 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7805.016 | uM | 30.78110 | 34.5910 | 0.3689 | -0.3932 | 4.9723 | 0.0114 | 0.9712 | 1.2059 | |
| CAMA-1 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9210.024 | uM | 0.02708 | 0.02780 | -0.1680 | -0.0321 | 2.3424 | 0.6362 | 0.9731 | 0.8697 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9210.131 | uM | inf | inf | 0.2276 | 0.2276 | 0.0000 | 0.5616 | 0.5267 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9210.011 | uM | 0.28886 | 0.05553 | 0.2266 | 0.2919 | 0.5315 | 0.4188 | 0.9037 | 0.9440 | |
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10755.15 | uM | inf | inf | 0.4395 | 0.4395 | 0.0000 | 0.2504 | 0.3664 | 0.7807 | ||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 10473.138 | uM | inf | 1.19780 | 0.7189 | 0.7475 | 4.9965 | 0.0394 | 0.9219 | 1.2872 | ||
| CAMA-1 | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12070.16 | uM | 1.30120 | 1.15090 | 0.2168 | 0.2294 | 4.9999 | 0.2666 | 0.9242 | 0.8453 | ||
| CAMA-1 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9210.001 | uM | 8.02190 | 17.5930 | -0.4354 | -1.0000 | 1.3989 | 0.2132 | 0.9502 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5912.098 | uM | inf | inf | 0.8785 | 0.8785 | 0.0000 | 0.0261 | -0.0048 | 1.0559 | |
| CAMA-1 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5911.09 | uM | inf | 1000.00000 | 0.7173 | 0.3149 | 0.2548 | 0.0942 | 0.6346 | 1.1067 |