Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5908.084 | uM | 9.94520 | 53.73860 | -0.8201 | -1.0000 | 0.6512 | 0.5517 | 0.9139 | 0.4873 | |
| BT-483 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5908.067 | uM | 8.88120 | 11.06370 | -0.9998 | -1.0000 | 4.9998 | 0.6011 | 0.8792 | 0.5143 | |
| BT-483 | HR+ | Luminal | Taxol | TUBB | TUBB | 9186.002 | uM | 0.04303 | 0.07132 | -0.2821 | -0.1433 | 0.4987 | 0.5139 | 0.8603 | 0.4768 | |
| BT-483 | HR+ | Luminal | Taxol | TUBB | TUBB | 7801.002 | uM | 0.02579 | 0.46550 | -0.4700 | -0.7694 | 0.3220 | 0.6538 | 0.9718 | 0.4140 | |
| BT-483 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 11855.159 | uM | 0.76686 | 1.19960 | -0.4152 | -0.3731 | 1.2458 | 0.3543 | 0.9845 | 0.6347 | |
| BT-483 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11855.135 | uM | inf | inf | 0.6973 | 0.6973 | 0.0000 | 0.1313 | -0.0247 | 0.6394 | |
| BT-483 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10696.148 | uM | inf | inf | 0.5256 | 0.5256 | 0.0000 | 0.2541 | 0.1135 | 0.3850 | |
| BT-483 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 11855.144 | uM | 0.00173 | 0.54075 | -0.9995 | -1.0000 | 0.1912 | 0.9073 | 0.6959 | 0.5961 | |
| BT-483 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10696.144 | uM | 0.00036 | 0.00456 | -0.9999 | -0.6629 | 0.3339 | 1.1855 | 0.8042 | 0.4505 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 7801.007 | uM | 0.02518 | 0.32234 | -0.7778 | -0.9515 | 0.4180 | 0.8978 | 0.9839 | 0.6446 | |
| BT-483 | HR+ | Luminal | Topotecan | TOP1 | TOP | 9186.121 | uM | 0.05069 | 0.14526 | -0.3775 | -0.4161 | 0.5752 | 0.7316 | 0.9911 | 0.8379 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11855.16 | uM | 1.75240 | 999.99910 | 0.2219 | -0.9837 | 0.1714 | 0.3534 | 0.7494 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10696.15 | uM | 2.24330 | 24.03060 | -0.1777 | -1.0000 | 0.4633 | 0.2784 | 0.8724 | 0.4740 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 7801.036 | uM | inf | inf | 0.5708 | 0.5708 | 0.0000 | 0.1871 | -0.0082 | 0.4291 | |
| BT-483 | HR+ | Luminal | Trametinib | MEK | MAPK | 7801.012 | uM | inf | inf | 0.7121 | 0.7121 | 0.0000 | 0.0923 | 0.2724 | 0.5600 | |
| BT-483 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9186.026 | uM | 9.98070 | 8.38730 | 0.7741 | 0.2905 | 5.0000 | -0.0274 | 0.7463 | 0.5108 | |
| BT-483 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5908.065 | uM | 8.3560 | 21.3020 | -0.9765 | -1.0000 | 1.1740 | 0.9257 | 0.9683 | 0.5136 | |
| BT-483 | HR+ | Luminal | Triciribine | AKT | AKT | 5908.074 | uM | 0.01754 | 0.14176 | -0.3535 | -0.5337 | 0.3476 | 0.6743 | 0.9586 | 0.5224 | |
| BT-483 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 11855.143 | uM | 317.72020 | 1000.00000 | -0.9260 | -0.8045 | 0.8364 | 0.4626 | 0.8601 | 0.5372 | |
| BT-483 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 10696.143 | uM | 459.30660 | 1000.00000 | -0.9495 | -0.7376 | 1.1649 | 0.3425 | 0.9403 | 0.5188 | |
| BT-483 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7801.018 | uM | 0.01410 | 0.02251 | -0.9914 | -0.5604 | 1.6079 | 0.9036 | 0.9338 | 0.5913 | |
| BT-483 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 5908.065 | uM | 45.68660 | 167.85230 | -0.9347 | -1.0000 | 0.8443 | 0.7898 | 0.9786 | 0.5136 | |
| BT-483 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11855.157 | uM | 67.55370 | 996.11240 | 0.4977 | -0.2530 | 0.1522 | 0.2936 | 0.8392 | 0.7986 | |
| BT-483 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10696.151 | uM | 0.22604 | 2.12580 | -0.8574 | -1.0000 | 0.4902 | 0.6822 | 0.9097 | 0.3690 | |
| BT-483 | HR+ | Luminal | ZM-447439 | AURK | AURK | 11855.16 | uM | inf | inf | 0.5429 | 0.5429 | 0.0000 | 0.3123 | 0.0079 | 0.6477 |