Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
CAMA-1
HR+
Luminal
 Baicalein
Lipoxygenase
Metabolism
10473.072
uM
78.07180
138.72950
 -0.1755 -0.9995 1.9104 0.1390
0.9482
 1.2996
CAMA-1
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
5911.074
uM
0.04547
0.09258
 -0.9460 -0.9060 1.4540 1.1535
0.9813
 1.1317
CAMA-1
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
5911.074
uM
0.04547
0.09258
 -0.9460 -0.9060 1.4540 1.1535
0.9813
 1.1317
CAMA-1
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
5912.074
uM
0.07426
0.11075
 -0.9824 -0.9577 2.6766 1.1107
0.9982
 0.9249
CAMA-1
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
5912.074
uM
0.07426
0.11075
 -0.9824 -0.9577 2.6766 1.1107
0.9982
 0.9249
CAMA-1
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14897.203
uM
0.00729
0.01189
 -0.9807 -0.9464 2.1693 1.3139
0.9983
 0.9464
CAMA-1
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14897.203
uM
0.00729
0.01189
 -0.9807 -0.9464 2.1693 1.3139
0.9983
 0.9464
CAMA-1
HR+
Luminal
 Bosutinib
Src
nRTK
12070.145
uM
2.27860
222.33270
 -0.1171 -1.0000 0.2398 0.3819
0.6008
 1.0737
CAMA-1
HR+
Luminal
 Bosutinib
Src
nRTK
10755.145
uM
27.8960
1000.00000
 0.3670 -0.7961 0.2661 0.2428
0.6406
 0.7688
CAMA-1
HR+
Luminal
 Bromopyruvic acid
Hexokinase II
Metabolism
12647.177
uM
0.09018
0.14255
 -0.9856 -0.9827 2.3738 0.8786
0.9956
 1.0387
CAMA-1
HR+
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
9210.011
uM
212.54010
365.14720
 -0.9298 -1.0000 2.0301 0.2289
0.9851
 0.9440
CAMA-1
HR+
Luminal
 Celecoxib
COX2
COX
10473.136
uM
inf
inf
 0.9467 0.9467 0.0000 0.0581
0.0000
 1.3186
CAMA-1
HR+
Luminal
 Cetuximab
EGFR
ErbB
9210.026
uM
inf
inf
 1.0481 1.0481 0.0000 -0.0377
-4.0710
 0.9102
CAMA-1
HR+
Luminal
 Cetuximab
EGFR
ErbB
7805.018
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0217
-0.4906
 1.1451
CAMA-1
HR+
Luminal
 CGC-11047
Polyamine analogue
7805.018
uM
422.43070
1000.00000
 -0.9572 -0.9395 1.2271 0.4304
0.6619
 1.1451
CAMA-1
HR+
Luminal
 CGC-11047
Polyamine analogue
9210.026
uM
847.57060
1000.00000
 -0.9180 -0.6431 4.9999 0.2844
0.7794
 0.9102
CAMA-1
HR+
Luminal
 Chk2 inhibitor II
CHK2
CHK
10473.14
uM
inf
inf
 0.8107 0.8107 0.0000 0.1044
-0.0156
 1.3126
CAMA-1
HR+
Luminal
 Chloroquine
12647.177
uM
12.40710
17.97030
 -0.9748 -1.0000 2.9656 0.2853
0.9653
 1.0387
CAMA-1
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
9210.131
uM
40.66860
63.52880
 -0.9410 -1.0000 2.4631 0.2319
0.9952
 0.9004
CAMA-1
HR+
Luminal
 CPT-11
TOP1
TOP
9210.121
uM
14.81040
12.33690
 0.1830 0.0879 1.0583 0.1111
0.9673
 0.8970
CAMA-1
HR+
Luminal
 Dactolisib
PI3K
PI3K
10755.146
uM
32.43130
85.79460
 0.4848 -1.0000 1.1293 0.1134
0.6407
 0.8035
CAMA-1
HR+
Luminal
 Dactolisib
PI3K
PI3K
12070.155
uM
0.18853
0.13650
 0.4037 0.2583 2.2512 0.3259
0.6994
 1.1729
CAMA-1
HR+
Luminal
 Dichloroacetate
PDK
PDK
12647.176
uM
inf
inf
 0.8702 0.8702 0.0000 0.0458
0.1561
 0.9797
CAMA-1
HR+
Luminal
 Disulfiram
Proteasome
Proteasome
12647.174
uM
13.59380
18.90890
 -0.9897 -1.0000 3.3289 0.3645
0.7716
 0.9362
CAMA-1
HR+
Luminal
 Docetaxel
TUBB
TUBB
9210.002
uM
0.00440
0.00479
 -0.2726 -0.2659 5.0000 0.7619
0.9830
 0.8958