Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAL-120 | TNBC | Luminal B | Ribavirin | 15272.211 | uM | inf | 13.26470 | 0.7584 | 0.7579 | 4.6650 | 0.0237 | 0.7753 | 2.1173 | |||
| CAL-120 | TNBC | Luminal B | Torkinib | 15272.211 | uM | 0.00725 | 0.01594 | -0.0893 | -0.1691 | 0.3699 | 0.7074 | 0.9944 | 2.1173 | |||
| CAL-148 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15276.203 | uM | 0.04767 | 0.09858 | -0.8960 | -0.9196 | 1.4362 | 1.0010 | 0.9955 | 1.6831 | |
| CAL-148 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15276.203 | uM | 0.04767 | 0.09858 | -0.8960 | -0.9196 | 1.4362 | 1.0010 | 0.9955 | 1.6831 | |
| CAL-148 | TNBC | - | Ribavirin | 15276.211 | uM | 42.67130 | 961.45530 | 0.4563 | -1.0000 | 0.3527 | 0.1428 | 0.9720 | 1.7025 | |||
| CAL-148 | TNBC | - | Torkinib | 15276.211 | uM | 0.01585 | 0.03734 | -0.3152 | -0.3524 | 0.6225 | 0.7594 | 0.9964 | 1.7025 | |||
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| CAL-85-1 | TNBC | - | Bortezomib | Proteasome | Proteasome | 15280.203 | uM | 0.00265 | 0.00507 | -0.9828 | -0.9851 | 1.6797 | 1.4734 | 0.9952 | 0.7211 | |
| CAL-85-1 | TNBC | - | Ribavirin | 15280.211 | uM | 104.41110 | 45.7480 | 0.6941 | 0.4856 | 4.2943 | -0.0088 | 0.8805 | 0.8608 | |||
| CAL-85-1 | TNBC | - | Torkinib | 15280.211 | uM | 0.00057 | 0.00844 | -0.8064 | -0.8633 | 0.3733 | 1.1993 | 0.9944 | 0.8608 | |||
| CAMA-1 | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7805.016 | uM | 34.74920 | 49.08090 | -0.9650 | -1.0000 | 3.1815 | 0.2413 | 0.9801 | 1.2059 | ||
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7805.05 | uM | 0.33059 | 0.62314 | -0.2532 | -0.2197 | 0.5745 | 0.4652 | 0.9470 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9210.037 | uM | 0.17414 | 0.82088 | -0.7513 | -0.7575 | 0.5948 | 0.6396 | 0.9590 | 0.8166 | |
| CAMA-1 | HR+ | Luminal | 2-deoxyglucose | 12647.177 | uM | inf | inf | 0.5238 | 0.5238 | 0.0000 | 0.1376 | 0.5672 | 1.0387 | |||
| CAMA-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 10755.143 | uM | 8.13980 | 33.83090 | 0.0811 | -0.1496 | 0.1837 | 0.5019 | 0.6967 | 0.9034 | |
| CAMA-1 | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12070.143 | uM | 180.68920 | 330.87140 | -0.0282 | -0.2049 | 0.5677 | 0.2807 | 0.9638 | 0.9561 | |
| CAMA-1 | HR+ | Luminal | 5-FU | TYMS | TYMS | 9210.131 | uM | 201.89680 | 1000.00000 | -0.4736 | -0.7823 | 0.5886 | 0.4803 | 0.9489 | 0.9004 | |
| CAMA-1 | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12070.158 | uM | 2.46530 | 3.35890 | -0.9601 | -0.9626 | 3.4700 | 0.4606 | 0.9893 | 1.1252 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5911.066 | uM | 18.70650 | 52.1250 | 0.2273 | -1.0000 | 1.0721 | 0.1631 | 0.7339 | 1.2414 | |
| CAMA-1 | HR+ | Luminal | AG1024 | IGF1R | RTK | 5912.066 | uM | inf | 7.5290 | 0.6927 | 0.6925 | 4.9956 | 0.0315 | 0.8458 | 1.0480 | |
| CAMA-1 | HR+ | Luminal | AG1478 | EGFR | ErbB | 7805.016 | uM | 34.64740 | 40.81490 | -0.6274 | -0.6288 | 4.9708 | 0.1381 | 0.9952 | 1.2059 | |
| CAMA-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12070.158 | uM | inf | inf | 0.8032 | 0.8032 | 0.0000 | 0.0455 | 0.3230 | 1.1252 | |
| CAMA-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10755.153 | uM | 8.99060 | 75.27280 | 0.1978 | -1.0000 | 0.5170 | 0.2011 | 0.750 | 0.7471 | |
| CAMA-1 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10473.141 | uM | 100.11090 | 277.79440 | 0.5604 | -0.2828 | 0.4392 | 0.1091 | 0.8789 | 1.2804 | |
| CAMA-1 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10755.072 | uM | inf | inf | 0.2784 | 0.2784 | 0.0000 | 0.2357 | 0.5071 | 0.7300 |