Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
BT-483
HR+
Luminal
 ICRF-193
TOP2
TOP
11855.157
uM
inf
inf
 0.7596 0.7596 0.0000 0.2419
0.0000
 0.7986
BT-483
HR+
Luminal
 ICRF-193
TOP2
TOP
10696.151
uM
inf
inf
 0.6306 0.6306 0.0000 0.1961
0.3820
 0.3690
BT-483
HR+
Luminal
 Imatinib
ABL/KIT/PDGFR
nRTK
5908.091
uM
27.00170
34.78310
 -0.9999 -1.0000 4.3384 0.5826
0.9173
 0.5109
BT-483
HR+
Luminal
 Ispinesib
KSP
Kinesin
5908.067
uM
0.06348
1.02470
 -0.9997 -1.0000 0.3950 0.6678
0.6757
 0.5143
BT-483
HR+
Luminal
 Ixabepilone
TUBB
TUBB
5908.095
uM
0.01982
1.49430
 -0.9998 -1.0000 0.2542 0.6572
0.6614
 0.5012
BT-483
HR+
Luminal
 JNK-IN-5A
JNK
JNK
10696.144
uM
0.47709
0.67112
 -0.4913 -0.4057 1.7410 0.6765
0.9246
 0.4505
BT-483
HR+
Luminal
 JNK-IN-5A
JNK
JNK
11855.144
uM
1.18910
1.26340
 -0.0349 -0.0456 1.4409 0.4155
0.9391
 0.5961
BT-483
HR+
Luminal
 L-779450
BRAF
MAPK
11855.161
uM
6.06830
274.20550
 0.0925 -1.0000 0.2883 0.2708
0.7203
 0.5957
BT-483
HR+
Luminal
 L-779450
BRAF
MAPK
10696.149
uM
12.06480
36.54270
 0.0320 -1.0000 0.9914 0.1649
0.8749
 0.5906
BT-483
HR+
Luminal
 Lapatinib
EGFR/HER2
ErbB
5908.098
uM
inf
inf
 0.7516 0.7516 0.0000 0.2163
-0.0860
 0.6091
BT-483
HR+
Luminal
 LBH589
HDAC
HDAC
11855.154
uM
0.05422
0.14655
 -0.8610 -0.8841 1.0239 0.8356
0.9802
 0.6282
BT-483
HR+
Luminal
 LBH589
HDAC
HDAC
10696.154
uM
0.08912
0.18312
 -0.9078 -0.8898 1.4196 0.7717
0.9982
 0.6070
BT-483
HR+
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
11855.154
uM
0.14887
8.54940
 -0.2219 -1.0000 0.2712 0.4974
0.9520
 0.6282
BT-483
HR+
Luminal
 Lestaurtinib
FLT3/JAK2/TrkA
RTK
10696.154
uM
0.98593
2.580
 -0.4393 -0.6228 0.8410 0.3343
0.9899
 0.6070
BT-483
HR+
Luminal
 Mebendazole
13130.174
uM
2.05160
1.15580
 0.2836 0.0818 0.3113 0.3396
0.8145
 0.5126
BT-483
HR+
Luminal
 Methotrexate
DHFR
Metabolism
5908.084
uM
71.22740
16.37190
 0.4303 0.1226 0.1913 0.3100
0.7460
 0.4873
BT-483
HR+
Luminal
 MG-132
Proteasome
Proteasome
11855.145
uM
0.12452
0.65010
 -0.8043 -0.9335 0.6373 0.7520
0.9370
 0.5070
BT-483
HR+
Luminal
 MG-132
Proteasome
Proteasome
11855.145
uM
0.12452
0.65010
 -0.8043 -0.9335 0.6373 0.7520
0.9370
 0.5070
BT-483
HR+
Luminal
 MG-132
Proteasome
Proteasome
10696.145
uM
0.14086
0.37044
 -0.9857 -1.0000 1.1362 0.8620
0.9840
 0.3316
BT-483
HR+
Luminal
 MG-132
Proteasome
Proteasome
10696.145
uM
0.14086
0.37044
 -0.9857 -1.0000 1.1362 0.8620
0.9840
 0.3316
BT-483
HR+
Luminal
 Pevonedistat
NAE1
NAE1
11855.135
uM
inf
inf
 0.7998 0.7998 0.0000 0.2110
0.0000
 0.6394
BT-483
HR+
Luminal
 Pevonedistat
NAE1
NAE1
10696.148
uM
0.07393
0.05716
 0.2512 0.1096 0.9616 0.5372
0.8201
 0.3850
BT-483
HR+
Luminal
 Nelfinavir
13130.174
uM
8.06510
11.70990
 -0.9209 -1.0000 2.9463 0.2776
0.9408
 0.5126
BT-483
HR+
Luminal
 Nilotinib
ABL
nRTK
10696.145
uM
inf
inf
 0.6817 0.6817 0.0000 0.2546
0.0751
 0.3316
BT-483
HR+
Luminal
 Nilotinib
ABL
nRTK
11855.145
uM
inf
inf
 0.3444 0.3444 0.0000 0.3027
0.5178
 0.5070