Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | Taxol | TUBB | TUBB | 9226.002 | uM | 0.00592 | 0.00637 | -0.1205 | -0.0457 | 1.1845 | 0.6864 | 0.9908 | 2.4245 | |
| HBL-100 | Unknown | Unknown | Taxol | TUBB | TUBB | 7808.002 | uM | 0.00567 | 0.00596 | -0.0881 | -0.0331 | 1.2754 | 0.6816 | 0.9935 | 2.3302 | |
| HBL-100 | Unknown | Unknown | Taxol | TUBB | TUBB | 7807.002 | uM | 0.00542 | 0.00688 | -0.2224 | -0.1947 | 1.3740 | 0.7868 | 0.9994 | 2.1668 | |
| HBL-100 | Unknown | Unknown | Topotecan | TOP1 | TOP | 7808.043 | uM | 0.01697 | 0.04691 | -0.8173 | -0.8019 | 0.9408 | 1.0846 | 0.9909 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Trametinib | MEK | MAPK | 9226.012 | uM | inf | 0.03632 | 0.8723 | 0.8653 | 0.3925 | 0.0676 | 0.6610 | 2.5039 | |
| HBL-100 | Unknown | Unknown | Trametinib | MEK | MAPK | 7807.036 | uM | inf | 0.09670 | 0.7568 | 0.7592 | 0.6422 | 0.1072 | 0.8697 | 2.0706 | |
| HBL-100 | Unknown | Unknown | Trametinib | MEK | MAPK | 7808.05 | uM | inf | 999.94320 | 0.7007 | 0.0271 | 0.1956 | 0.1320 | 0.9342 | 2.5177 | |
| HBL-100 | Unknown | Unknown | Trastuzumab | HER2 | ErbB | 7429.102 | uM | inf | 1.42040 | 0.9243 | 0.9093 | 0.9467 | 0.0072 | 0.8090 | 2.4347 | |
| HBL-100 | Unknown | Unknown | Triciribine | AKT | AKT | 7429.074 | uM | inf | 0.28066 | 0.8466 | 0.8727 | 1.1019 | 0.0485 | 0.8190 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 7807.042 | uM | 0.00755 | 0.00930 | -0.7909 | -0.3868 | 2.7529 | 0.8927 | 0.9460 | 2.0250 | |
| HBL-100 | Unknown | Unknown | Vinorelbine | TUBB | TUBB | 7808.052 | uM | 0.01036 | 0.01169 | -0.8053 | -0.4166 | 5.0000 | 0.9087 | 0.9473 | 2.4842 | |
| HCC1143 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7809.016 | uM | inf | inf | 0.3854 | 0.3854 | 0.0000 | 0.1556 | 0.5101 | 1.6622 | ||
| HCC1143 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7810.016 | uM | 159.09790 | 169.8520 | 0.4286 | -0.1925 | 4.9796 | -0.0031 | 0.9506 | 0.9032 | ||
| HCC1143 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 9233.037 | uM | 0.13452 | 0.14749 | -0.6831 | -0.2923 | 4.9987 | 0.6200 | 0.9412 | 1.2235 | |
| HCC1143 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7810.037 | uM | 0.10847 | 0.11854 | -0.5893 | -0.2795 | 4.9996 | 0.6702 | 0.9570 | 1.0223 | |
| HCC1143 | TNBC | Basal A | 2-deoxyglucose | 13099.177 | uM | 998.14080 | 1000.00000 | -0.0218 | -0.0047 | 5.0000 | 0.0854 | 0.7290 | 0.7419 | |||
| HCC1143 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 12112.143 | uM | 129.51890 | 410.77330 | -0.0337 | -0.3158 | 0.4242 | 0.3100 | 0.9533 | 1.6893 | |
| HCC1143 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7809.017 | uM | 623.11290 | 167.76560 | 0.2797 | 0.2268 | 0.4605 | 0.3087 | 0.9302 | 1.7591 | |
| HCC1143 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7810.017 | uM | 79.51050 | 198.63970 | -0.3272 | -0.3499 | 0.5794 | 0.4638 | 0.9680 | 0.8986 | |
| HCC1143 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 12112.158 | uM | 1.6130 | 4.98890 | -0.8683 | -1.0000 | 0.9730 | 0.5012 | 0.9581 | 1.8430 | |
| HCC1143 | TNBC | Basal A | AG1024 | IGF1R | RTK | 7430.066 | uM | 24.74450 | 15.11440 | 0.4325 | 0.3509 | 2.4542 | 0.0336 | 0.9802 | 1.7623 | |
| HCC1143 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7810.016 | uM | 461.70710 | 201.00470 | 0.8473 | 0.4892 | 4.6083 | -0.0029 | 0.6326 | 0.9032 | |
| HCC1143 | TNBC | Basal A | AG1478 | EGFR | ErbB | 7809.016 | uM | 78.28920 | 222.80580 | 0.1379 | -1.0000 | 1.0504 | 0.1728 | 0.7670 | 1.6622 | |
| HCC1143 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 12112.158 | uM | inf | inf | 0.8747 | 0.8747 | 0.0000 | 0.0790 | 0.420 | 1.8430 | |
| HCC1143 | TNBC | Basal A | Baicalein | Lipoxygenase | Metabolism | 7430.073 | uM | 131.22550 | 48.8760 | 0.4694 | 0.3223 | 1.0476 | 0.0854 | 0.9736 | 1.9673 |