Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 12000.147 | uM | 1.29190 | 5.58930 | -0.7875 | -1.0000 | 0.7500 | 0.5438 | 0.9891 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 12084.147 | uM | 2.45050 | 6.10990 | -0.9226 | -1.0000 | 1.2025 | 0.4911 | 0.9923 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7436.086 | uM | 0.05410 | 0.10839 | -0.4362 | -0.3666 | 0.7914 | 0.5942 | 0.9890 | 1.2908 | |
| HCC1395 | TNBC | Basal B | Omipalisib | PI3K | PI3K | 7435.086 | uM | 0.04668 | 0.08962 | -0.5533 | -0.4697 | 1.0156 | 0.6598 | 0.9947 | 0.7985 | |
| HCC1395 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7814.011 | uM | 6.40760 | 18.72460 | -0.9862 | -1.0000 | 1.0245 | 0.5881 | 0.9818 | 0.9472 | |
| HCC1395 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9254.12 | uM | 13.53450 | 28.71380 | -0.9973 | -1.0000 | 1.4607 | 0.5367 | 0.9858 | 1.1139 | |
| HCC1395 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9258.011 | uM | 9.15040 | 20.36390 | -0.9998 | -1.0000 | 1.3733 | 0.5503 | 0.9911 | 0.6984 | |
| HCC1395 | TNBC | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7813.011 | uM | 15.19250 | 28.71610 | -0.9984 | -1.0000 | 1.7256 | 0.4886 | 0.9928 | 0.8718 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 12000.147 | uM | 2.23580 | 4.13130 | -0.9833 | -1.0000 | 1.7892 | 0.5376 | 0.9627 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Oxamflatin | HDAC | HDAC | 12084.147 | uM | 1.98330 | 4.23350 | -0.9934 | -0.9984 | 1.4474 | 0.4051 | 0.9945 | 1.0888 | |
| HCC1395 | TNBC | Basal B | PD 98059 | MEK | MAPK | 12000.159 | uM | inf | inf | 0.5712 | 0.5712 | 0.0000 | 0.2188 | 0.2067 | 0.9695 | |
| HCC1395 | TNBC | Basal B | PD 98059 | MEK | MAPK | 12084.159 | uM | inf | inf | 0.7553 | 0.7553 | 0.0000 | 0.1165 | 0.3011 | 1.2294 | |
| HCC1395 | TNBC | Basal B | PD173074 | FGFR1/3 | RTK | 7436.093 | uM | 0.71193 | 4.33350 | -0.7459 | -1.0000 | 0.6083 | 0.3893 | 0.9663 | 1.2596 | |
| HCC1395 | TNBC | Basal B | PD184352 | MEK | MAPK | 12084.155 | uM | inf | inf | 0.9292 | 0.9292 | 0.0000 | 0.0091 | 0.2182 | 1.2955 | |
| HCC1395 | TNBC | Basal B | PD184352 | MEK | MAPK | 12084.155 | uM | inf | inf | 0.9292 | 0.9292 | 0.0000 | 0.0091 | 0.2182 | 1.2955 | |
| HCC1395 | TNBC | Basal B | PD184352 | MEK | MAPK | 12000.155 | uM | inf | 0.04759 | 0.7096 | 0.6521 | 0.1954 | 0.1775 | 0.6664 | 0.8592 | |
| HCC1395 | TNBC | Basal B | PD184352 | MEK | MAPK | 12000.155 | uM | inf | 0.04759 | 0.7096 | 0.6521 | 0.1954 | 0.1775 | 0.6664 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7435.095 | uM | inf | inf | 0.8669 | 0.8669 | 0.0000 | 0.0762 | -0.0489 | 0.8762 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7436.095 | uM | inf | inf | 0.9643 | 0.9643 | 0.0000 | 0.0131 | 0.0000 | 1.3597 | |
| HCC1395 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7435.065 | uM | inf | inf | 0.7303 | 0.7303 | 0.0000 | 0.1363 | 0.4121 | 0.8513 | |
| HCC1395 | TNBC | Basal B | PS-1145 | IKK | NFKB | 7436.065 | uM | inf | 334.83990 | 0.7935 | 0.7935 | 5.0000 | 0.0156 | 0.8959 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7436.067 | uM | inf | inf | 0.9747 | 0.9747 | 0.0000 | 0.0019 | 0.2592 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Purvalanol A | CDK1 | CDK | 7435.067 | uM | inf | inf | 0.6392 | 0.6392 | 0.0000 | 0.0374 | 0.2883 | 0.7691 | |
| HCC1395 | TNBC | Basal B | QNZ | NFkB | NFKB | 7436.096 | uM | 0.04421 | 0.01523 | 0.3122 | 0.3346 | 1.0381 | 0.4050 | 0.9728 | 1.3979 | |
| HCC1395 | TNBC | Basal B | SB-3CT | MMP2/9 | MMP | 12000.168 | uM | inf | inf | 0.7308 | 0.7308 | 0.0000 | 0.1195 | 0.3207 | 0.7873 |