Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Chloroquine | 13038.177 | uM | 11.2470 | 14.01040 | -0.9991 | -0.9998 | 5.0000 | 0.1931 | 0.9957 | 0.9161 | |||
| HCC1569 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7825.017 | uM | 13.78420 | 6.5780 | 0.2318 | 0.3003 | 1.2409 | 0.1910 | 0.9602 | 2.0855 | |
| HCC1569 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7824.017 | uM | 4.64290 | 6.51640 | -0.2086 | -0.1820 | 0.9156 | 0.3459 | 0.9706 | 1.6694 | |
| HCC1569 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9347.017 | uM | 39.4730 | 166.61560 | -0.1599 | -1.0000 | 0.7629 | 0.1655 | 0.9889 | 1.6249 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 7825.007 | uM | inf | 81.60280 | 0.8135 | 0.5446 | 3.6135 | 0.0106 | 0.5793 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 9347.121 | uM | 25.55240 | 49.33220 | -0.4281 | -1.0000 | 1.6700 | 0.1014 | 0.9929 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 10872.155 | uM | 0.35934 | 0.28364 | 0.3171 | 0.3468 | 5.0000 | 0.2837 | 0.7323 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 12523.155 | uM | 0.56295 | 0.43605 | 0.4029 | 0.3606 | 5.0000 | 0.2289 | 0.8519 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Dichloroacetate | PDK | PDK | 13038.176 | uM | inf | inf | 0.9283 | 0.9283 | 0.0000 | 0.0431 | 0.2237 | 1.3069 | |
| HCC1569 | HER2amp | Basal A | Disulfiram | Proteasome | Proteasome | 13038.174 | uM | inf | inf | 0.7714 | 0.7714 | 0.0000 | 0.2612 | 0.5075 | 1.2027 | |
| HCC1569 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 9347.002 | uM | inf | 0.00163 | 0.5098 | 0.5087 | 1.2928 | 0.3277 | 0.9210 | 1.4904 | |
| HCC1569 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 13038.002 | uM | 0.00570 | 0.00427 | 0.1042 | 0.1775 | 1.5208 | 0.4820 | 0.9830 | 1.2045 | |
| HCC1569 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 9347.121 | uM | 1.05950 | 1.1610 | -0.2489 | -0.0990 | 1.9753 | 0.3387 | 0.9752 | 1.4523 | |
| HCC1569 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 7825.007 | uM | 10.52510 | 19.97490 | -0.0130 | -0.3301 | 0.7912 | 0.1642 | 0.9812 | 1.5199 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 7824.017 | uM | 0.69563 | 7.34590 | -0.9871 | -1.0000 | 0.4661 | 0.5315 | 0.8744 | 1.6694 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 9347.017 | uM | 1.31210 | 10.00520 | -0.9683 | -1.0000 | 0.5408 | 0.4729 | 0.9115 | 1.6249 | |
| HCC1569 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 7825.017 | uM | 1.60090 | 11.98260 | -0.9503 | -1.0000 | 0.5458 | 0.4551 | 0.9163 | 2.0855 | |
| HCC1569 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7447.09 | uM | 24.60320 | 146.28430 | 0.2284 | -1.0000 | 0.6163 | 0.1574 | 0.9437 | 1.5863 | |
| HCC1569 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7449.091 | uM | 20.87780 | 11.20460 | 0.3606 | 0.3331 | 1.7631 | 0.0911 | 0.9914 | 1.8158 | |
| HCC1569 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7449.074 | uM | 90.77370 | 508.07770 | 0.1261 | -1.0000 | 0.6379 | 0.1331 | 0.9895 | 2.0321 | |
| HCC1569 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7447.074 | uM | 27.38890 | 43.41460 | 0.1521 | -0.1436 | 0.5480 | 0.2366 | 0.9905 | 1.5411 | |
| HCC1569 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7448.074 | uM | 176.56740 | 999.88570 | 0.3682 | -0.7709 | 0.5380 | 0.1223 | 0.9905 | 2.8830 | |
| HCC1569 | HER2amp | Basal A | Everolimus | MTOR | MTOR | 10872.156 | uM | 0.54271 | 12.36520 | -0.8357 | -1.0000 | 0.3514 | 0.4642 | 0.6959 | 1.5028 | |
| HCC1569 | HER2amp | Basal A | Everolimus | MTOR | MTOR | 12523.164 | uM | 0.06557 | 5.9890 | -0.7287 | -1.0000 | 0.2434 | 0.5969 | 0.7617 | 0.8230 | |
| HCC1569 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7449.084 | uM | 0.47938 | 0.82279 | -0.8295 | -0.8159 | 1.7913 | 0.5460 | 0.9979 | 2.1410 |