Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7451.095 | uM | 0.00335 | 0.00636 | -0.8230 | -0.3798 | 0.8819 | 0.8966 | 0.8817 | 2.2028 | |
| HCC1806 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7450.095 | uM | 0.00797 | 0.01154 | -0.8836 | -0.4702 | 1.7890 | 0.8890 | 0.9427 | 1.7844 | |
| HCC1806 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 12239.144 | uM | 119.91440 | 163.06790 | 0.3489 | -1.0000 | 3.5740 | 0.0798 | 0.7292 | 2.1598 | |
| HCC1806 | TNBC | Basal A | L-779450 | BRAF | MAPK | 12239.161 | uM | 13.15840 | 21.02110 | -0.7694 | -1.0000 | 2.3451 | 0.1301 | 0.9958 | 1.8129 | |
| HCC1806 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7450.098 | uM | inf | 1.66810 | 0.9020 | 0.9019 | 3.3261 | 0.0024 | 0.7525 | 2.2139 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 12239.154 | uM | 0.21396 | 0.33108 | -0.7674 | -0.7837 | 2.1598 | 0.6557 | 0.9954 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12239.154 | uM | 0.17076 | 0.33908 | -0.7290 | -0.6804 | 1.2522 | 0.5946 | 0.9966 | 2.2015 | |
| HCC1806 | TNBC | Basal A | Mebendazole | 12702.174 | uM | 0.29217 | 0.33503 | -0.2552 | -0.1582 | 2.0078 | 0.4906 | 0.9887 | 1.8506 | |||
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7450.084 | uM | inf | inf | 0.9424 | 0.9424 | 0.0000 | 0.0000 | 0.5666 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7451.085 | uM | 0.00695 | 0.00649 | 0.1463 | 0.1465 | 5.0000 | 0.7130 | 0.9890 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Methylglyoxal | 13543.184 | uM | 63.26310 | 271.02190 | -0.9881 | -1.0000 | 0.7551 | 0.8885 | 0.8997 | 1.5433 | |||
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14155.189 | uM | inf | inf | -0.8537 | -0.8537 | 0.0000 | 0.5966 | 0.5536 | 1.7812 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14155.189 | uM | inf | inf | -0.8537 | -0.8537 | 0.0000 | 0.5966 | 0.5536 | 1.7812 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14128.189 | uM | inf | inf | -0.6315 | -0.6315 | 0.0000 | 0.4616 | 0.5621 | 2.7793 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14128.189 | uM | inf | inf | -0.6315 | -0.6315 | 0.0000 | 0.4616 | 0.5621 | 2.7793 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14634.189 | uM | 0.56342 | 0.86102 | -0.7560 | -0.7391 | 2.1399 | 0.6123 | 0.9966 | 2.1561 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14634.189 | uM | 0.56342 | 0.86102 | -0.7560 | -0.7391 | 2.1399 | 0.6123 | 0.9966 | 2.1561 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 12239.145 | uM | 0.30347 | 0.41921 | -0.7519 | -0.7356 | 2.8001 | 0.6909 | 0.9996 | 2.1348 | |
| HCC1806 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 12239.145 | uM | 0.30347 | 0.41921 | -0.7519 | -0.7356 | 2.8001 | 0.6909 | 0.9996 | 2.1348 | |
| HCC1806 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 12239.135 | uM | 0.02626 | 0.04694 | -0.4881 | -0.3585 | 0.9307 | 0.7524 | 0.9887 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Nelfinavir | 12702.174 | uM | 8.77290 | 11.30080 | -0.8571 | -0.8812 | 4.0129 | 0.1752 | 0.9941 | 1.8506 | |||
| HCC1806 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12239.145 | uM | inf | inf | 0.9597 | 0.9597 | 0.0000 | 0.0201 | -0.0222 | 2.1348 | |
| HCC1806 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 12239.152 | uM | 2.4250 | 3.86620 | -0.7736 | -0.7755 | 2.0078 | 0.5464 | 0.9946 | 2.2104 | |
| HCC1806 | TNBC | Basal A | NU6102 | CDK1/2 | CDK | 12239.147 | uM | 17.5460 | 20.68470 | -0.6115 | -0.6167 | 4.8829 | 0.1214 | 0.9982 | 2.0027 | |
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7450.066 | uM | 167.60080 | 439.27520 | 0.7696 | -0.8645 | 1.0419 | 0.0355 | 0.8036 | 2.3863 |