Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7451.066 | uM | 30.75380 | 40.36790 | -0.4347 | -0.7136 | 3.2597 | 0.1026 | 0.9964 | 2.0040 | |
| HCC1806 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 12239.147 | uM | 8.33890 | 11.24390 | -0.6158 | -0.6191 | 2.6956 | 0.3167 | 0.9978 | 2.0027 | |
| HCC1806 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7451.086 | uM | 0.04011 | 0.13686 | -0.5411 | -0.5438 | 0.5997 | 0.6623 | 0.9944 | 1.9434 | |
| HCC1806 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9376.011 | uM | 4.45210 | 17.95240 | -0.8709 | -1.0000 | 0.7879 | 0.5509 | 0.9784 | 1.5809 | |
| HCC1806 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7829.011 | uM | 2.20680 | 12.14170 | -0.8339 | -1.0000 | 0.6443 | 0.6323 | 0.9812 | 1.8746 | |
| HCC1806 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 12239.147 | uM | 0.96507 | 2.60940 | -0.8254 | -0.9653 | 1.0809 | 0.5157 | 0.9885 | 2.0027 | |
| HCC1806 | TNBC | Basal A | PD 98059 | MEK | MAPK | 12239.152 | uM | inf | inf | 0.9055 | 0.9055 | 0.0000 | 0.0656 | -0.0219 | 2.2104 | |
| HCC1806 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7451.093 | uM | 4.57730 | 6.63020 | -0.4720 | -0.5343 | 1.9616 | 0.2371 | 0.9894 | 2.1935 | |
| HCC1806 | TNBC | Basal A | PD184352 | MEK | MAPK | 12239.155 | uM | inf | inf | 0.9084 | 0.9084 | 0.0000 | 0.0478 | 0.4412 | 2.1474 | |
| HCC1806 | TNBC | Basal A | PD184352 | MEK | MAPK | 12239.155 | uM | inf | inf | 0.9084 | 0.9084 | 0.0000 | 0.0478 | 0.4412 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7451.095 | uM | inf | inf | 0.7452 | 0.7452 | 0.0000 | 0.2906 | 0.3518 | 2.2028 | |
| HCC1806 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7450.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.7844 | |
| HCC1806 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7450.065 | uM | inf | inf | 1.0181 | 1.0181 | 0.0000 | 0.0205 | 0.0000 | 2.4231 | |
| HCC1806 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7451.065 | uM | inf | 180.29960 | 0.9525 | 0.9339 | 0.2460 | 0.0196 | 0.6361 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7451.067 | uM | inf | inf | 0.8609 | 0.8609 | 0.0000 | 0.0355 | 0.3320 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7450.067 | uM | 34.25460 | 25.24120 | 0.3917 | 0.3914 | 5.0000 | 0.0798 | 0.9827 | 2.2419 | |
| HCC1806 | TNBC | Basal A | QNZ | NFkB | NFKB | 7451.096 | uM | inf | 0.06767 | 0.6556 | 0.6764 | 1.5258 | 0.1610 | 0.9845 | 2.1851 | |
| HCC1806 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 12239.144 | uM | inf | 142.19340 | 0.8314 | 0.6181 | 0.6735 | 0.0345 | 0.8344 | 2.1598 | |
| HCC1806 | TNBC | Basal A | Selumetinib | MEK | MAPK | 12239.155 | uM | inf | 0.33687 | 0.7885 | 0.7813 | 0.9393 | 0.0895 | 0.8826 | 2.1474 | |
| HCC1806 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 12239.165 | uM | 9.67380 | 17.26610 | -0.8465 | -0.9909 | 1.8858 | 0.2211 | 0.9992 | 2.0705 | |
| HCC1806 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7830.068 | uM | inf | inf | 0.6889 | 0.6889 | 0.0000 | 0.1423 | 0.5692 | 1.8365 | |
| HCC1806 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7450.069 | uM | inf | 0.61592 | 0.8392 | 0.8488 | 1.1485 | 0.0327 | 0.8505 | 2.2471 | |
| HCC1806 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7450.084 | uM | inf | inf | 0.5029 | 0.5029 | 0.0000 | 0.0525 | 0.3472 | 2.3432 | |
| HCC1806 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7451.085 | uM | 54.5510 | 77.17010 | -0.8510 | -0.8768 | 2.9202 | 0.2342 | 0.9942 | 2.1458 | |
| HCC1806 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7450.067 | uM | 8.65720 | 13.48560 | -0.9123 | -0.9159 | 2.3484 | 0.3507 | 0.9981 | 2.2419 |