Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 7837.017 | uM | 0.24556 | 0.50357 | -0.9883 | -0.8902 | 1.4238 | 0.8549 | 0.9929 | 1.4255 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7454.092 | uM | 1.06490 | 35.62910 | -0.0632 | -1.0000 | 0.3130 | 0.3444 | 0.8804 | 1.2402 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7455.092 | uM | 13.18290 | 51.93090 | 0.1595 | -1.0000 | 0.8013 | 0.0884 | 0.9620 | 1.6605 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7456.091 | uM | 2.67810 | 2.49550 | 0.1750 | 0.0191 | 0.5509 | 0.2778 | 0.9854 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 7457.09 | uM | 7.4150 | 31.9160 | 0.2264 | -0.3592 | 0.3709 | 0.2375 | 0.9906 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7457.074 | uM | 0.87235 | 5.0640 | -0.7665 | -0.9731 | 0.6144 | 0.6928 | 0.9844 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Etoposide | TOP2 | TOP | 7456.074 | uM | 1.5450 | 5.74210 | -0.6725 | -0.7985 | 0.7270 | 0.5693 | 0.9867 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Everolimus | MTOR | MTOR | 11055.156 | uM | 0.62409 | 9.09660 | -0.8901 | -1.0000 | 0.4100 | 0.4574 | 0.7682 | 1.5301 | |
| HCC1954 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7457.084 | uM | 0.27072 | 0.36801 | -0.8722 | -0.8629 | 3.2661 | 0.6637 | 0.9979 | 1.8520 | |
| HCC1954 | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7456.084 | uM | 0.31254 | 0.47190 | -0.8694 | -0.8430 | 2.3979 | 0.6118 | 0.9984 | 1.9822 | |
| HCC1954 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 11055.149 | uM | inf | 1000.00000 | 0.8007 | 0.3725 | 0.2559 | 0.0652 | 0.8798 | 1.6723 | |
| HCC1954 | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 11055.154 | uM | inf | inf | 0.9813 | 0.9813 | 0.0000 | 0.0080 | -0.0117 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 9386.132 | uM | inf | inf | 0.7520 | 0.7520 | 0.0000 | 0.1148 | 0.0425 | 1.4083 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 7837.016 | uM | 0.63768 | 9.62580 | -0.3488 | -1.0000 | 0.4047 | 0.4170 | 0.8709 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 7839.016 | uM | 2.34040 | 8.15740 | -0.6232 | -1.0000 | 0.8799 | 0.2539 | 0.9792 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | Gefitinib | EGFR | ErbB | 7836.016 | uM | 3.16010 | 11.63650 | -0.4521 | -1.0000 | 0.8428 | 0.2443 | 0.9855 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | Geldanamycin | HSP90 | HSP90 | 9386.012 | uM | 0.00916 | 0.01053 | -0.3816 | -0.2949 | 3.3202 | 0.9016 | 0.9952 | 1.4141 | |
| HCC1954 | HER2amp | Basal A | Gemcitabine | DNA replication | DNA replication | 9386.011 | uM | inf | 0.01184 | 0.6016 | 0.6206 | 0.8409 | 0.2743 | 0.9746 | 1.5229 | |
| HCC1954 | HER2amp | Basal A | Glycyl-H-1152 | ROCK2 | 11055.15 | uM | inf | inf | 0.8945 | 0.8945 | 0.0000 | -0.0190 | 0.5352 | 1.6412 | ||
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 9386.001 | uM | 5.04710 | 9.51350 | -0.8649 | -1.0000 | 1.7331 | 0.2427 | 0.9794 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 7839.001 | uM | 3.91050 | 8.65220 | -0.8109 | -1.0000 | 1.3834 | 0.2338 | 0.9835 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 7837.001 | uM | 3.3970 | 7.34280 | -0.8678 | -1.0000 | 1.4253 | 0.2376 | 0.9916 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7454.092 | uM | inf | inf | 0.7036 | 0.7036 | 0.0000 | 0.2005 | 0.0931 | 1.2402 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7457.09 | uM | inf | inf | 0.9111 | 0.9111 | 0.0000 | 0.0435 | 0.5105 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7456.098 | uM | inf | 2.98790 | 0.7969 | 0.8533 | 4.9991 | 0.0495 | 0.6286 | 1.7388 |