Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7455.098 | uM | 4.69590 | 4.83720 | -0.0544 | -0.0571 | 3.6461 | 0.2782 | 0.9262 | 1.3433 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7454.098 | uM | 11.22020 | 18.91190 | -0.8748 | -1.0000 | 2.1043 | 0.2733 | 0.9660 | 1.2964 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7457.098 | uM | 12.50550 | 23.65110 | -0.7200 | -1.0000 | 1.7240 | 0.2032 | 0.9911 | 1.8323 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7455.092 | uM | 32.97390 | 41.07660 | -0.8400 | -1.0000 | 5.0000 | 0.0859 | 0.9941 | 1.6605 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7456.091 | uM | 6.77990 | 8.30110 | -0.8487 | -0.8502 | 4.9076 | 0.3833 | 0.9974 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 7457.07 | uM | 7.230 | 13.91740 | -0.7848 | -0.9295 | 1.6040 | 0.2631 | 0.9975 | 1.5631 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 7839.001 | uM | 0.00067 | 0.00070 | -0.4867 | -0.1112 | 5.0000 | 0.8932 | 0.8549 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 9386.001 | uM | 0.00862 | 0.01038 | -0.6745 | -0.4278 | 3.3304 | 0.8885 | 0.9609 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK461364 | PLK1 | PLK | 7837.001 | uM | 0.00799 | 0.00895 | -0.4876 | -0.3851 | 5.0000 | 0.8912 | 0.9776 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 7839.001 | uM | 0.02230 | 0.02766 | -0.5742 | -0.3190 | 2.2929 | 0.7255 | 0.9629 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 9386.001 | uM | 0.02279 | 0.02968 | -0.7003 | -0.5767 | 2.9028 | 0.8609 | 0.9930 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 7837.001 | uM | 0.01816 | 0.02515 | -0.6911 | -0.5667 | 2.3282 | 0.8517 | 0.9943 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | Ibandronate | FDPS | 11055.143 | uM | 58.56780 | 59.77120 | -0.0661 | -0.0398 | 3.7613 | 0.2374 | 0.9954 | 1.7215 | ||
| HCC1954 | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 11055.151 | uM | 48.44540 | 999.70680 | 0.4720 | -0.4729 | 0.2199 | 0.1876 | 0.8897 | 1.8913 | |
| HCC1954 | HER2amp | Basal A | IKK16 | IKK | NFKB | 7454.093 | uM | 1.95380 | 3.5180 | -0.9269 | -0.9969 | 1.8644 | 0.5728 | 0.9463 | 1.3347 | |
| HCC1954 | HER2amp | Basal A | IKK16 | IKK | NFKB | 7455.093 | uM | 1.59460 | 2.6590 | -0.8567 | -0.8897 | 1.9992 | 0.4552 | 0.9973 | 1.7255 | |
| HCC1954 | HER2amp | Basal A | IKK16 | IKK | NFKB | 10469.1 | uM | 2.06480 | 3.12650 | -0.9054 | -0.9276 | 2.5287 | 0.4622 | 0.9989 | 1.5717 | |
| HCC1954 | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7454.092 | uM | 7.75220 | 18.65990 | -0.9487 | -1.0000 | 1.2507 | 0.6053 | 0.9808 | 1.2402 | |
| HCC1954 | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7456.091 | uM | 5.13170 | 10.86530 | -0.8855 | -0.9006 | 1.3731 | 0.5955 | 0.9967 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7455.092 | uM | 13.0090 | 19.65330 | -0.8605 | -0.8359 | 2.3818 | 0.4627 | 0.9983 | 1.6605 | |
| HCC1954 | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7457.09 | uM | 10.43810 | 16.94650 | -0.8714 | -0.8872 | 2.1057 | 0.5127 | 0.9987 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7457.067 | uM | 0.02045 | 0.02659 | -0.9101 | -0.6758 | 3.2605 | 0.9330 | 0.9852 | 1.8574 | |
| HCC1954 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 7456.067 | uM | 0.02697 | 0.03224 | -0.8657 | -0.7198 | 5.0000 | 0.9493 | 0.9949 | 1.8797 | |
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7457.094 | uM | 0.00051 | 0.00078 | -0.8956 | -0.6816 | 2.0313 | 1.5901 | 0.9463 | 1.8462 | |
| HCC1954 | HER2amp | Basal A | Ixabepilone | TUBB | TUBB | 7455.095 | uM | 0.00203 | 0.00339 | -0.9014 | -0.6099 | 1.5659 | 1.1517 | 0.9624 | 1.8461 |