Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7451.067 | uM | 3.85010 | 6.87260 | -0.8258 | -0.8561 | 1.7219 | 0.4693 | 0.9990 | 2.0570 | |
| HCC1806 | TNBC | Basal A | TAPI-0 | TACE/Collagenase | 7451.096 | uM | inf | 3.8750 | 0.7347 | 0.6534 | 0.5656 | 0.0770 | 0.9490 | 2.1851 | ||
| HCC1806 | TNBC | Basal A | Taxol | TUBB | TUBB | 9376.002 | uM | 0.00736 | 0.01035 | -0.5241 | -0.4275 | 1.8127 | 0.8756 | 0.9937 | 1.5057 | |
| HCC1806 | TNBC | Basal A | Taxol | TUBB | TUBB | 7829.002 | uM | 0.00654 | 0.00859 | -0.6554 | -0.5946 | 2.8793 | 1.0258 | 0.9950 | 1.8681 | |
| HCC1806 | TNBC | Basal A | Taxol | TUBB | TUBB | 12702.002 | uM | 0.00503 | 0.00695 | -0.5565 | -0.5283 | 2.2293 | 1.0058 | 0.9990 | 1.8712 | |
| HCC1806 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 12239.152 | uM | 0.63654 | 0.88180 | -0.6688 | -0.6355 | 2.5166 | 0.4858 | 0.9954 | 2.2104 | |
| HCC1806 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 12239.135 | uM | inf | 139.88920 | 0.8108 | 0.5708 | 4.7176 | -0.0202 | 0.7417 | 2.0860 | |
| HCC1806 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 12239.144 | uM | 28.59970 | 54.3170 | -0.6680 | -1.0000 | 1.7127 | 0.2315 | 0.9575 | 2.1598 | |
| HCC1806 | TNBC | Basal A | Topotecan | TOP1 | TOP | 9376.121 | uM | 0.02208 | 0.07165 | -0.8690 | -0.8510 | 0.8445 | 1.0381 | 0.9964 | 1.3803 | |
| HCC1806 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12239.16 | uM | 18.690 | 37.25160 | 0.0878 | -1.0000 | 1.5929 | 0.0829 | 0.9812 | 1.8654 | |
| HCC1806 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 7451.093 | uM | inf | 2.46790 | 0.5184 | 0.5041 | 1.4693 | 0.1472 | 0.9736 | 2.1935 | |
| HCC1806 | TNBC | Basal A | Trametinib | MEK | MAPK | 7829.036 | uM | inf | 0.00253 | 0.5231 | 0.5314 | 1.2413 | 0.3159 | 0.9745 | 1.9542 | |
| HCC1806 | TNBC | Basal A | Trametinib | MEK | MAPK | 9376.024 | uM | inf | 0.00202 | 0.6940 | 0.6946 | 3.4269 | 0.2081 | 0.9818 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 9376.026 | uM | inf | inf | 0.9395 | 0.9395 | 0.0000 | -0.0232 | 0.0979 | 1.6827 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7451.065 | uM | 10.10380 | 14.65910 | -0.7397 | -0.7271 | 2.4126 | 0.7962 | 0.9982 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7450.065 | uM | 13.14030 | 20.61310 | -0.6278 | -0.6243 | 1.7996 | 0.7072 | 0.9983 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Triciribine | AKT | AKT | 7450.074 | uM | 0.07746 | 0.17066 | -0.4285 | -0.3470 | 0.6672 | 0.5284 | 0.9782 | 2.2338 | |
| HCC1806 | TNBC | Basal A | Triciribine | AKT | AKT | 7451.074 | uM | 1.06430 | 12.69480 | 0.0309 | -0.6620 | 0.3402 | 0.3257 | 0.9971 | 2.1799 | |
| HCC1806 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 12239.143 | uM | 859.64440 | 1000.00000 | -0.4116 | -0.0836 | 1.0222 | 0.2392 | 0.7203 | 2.1267 | |
| HCC1806 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7829.042 | uM | 0.00562 | 0.00686 | -0.7934 | -0.5149 | 3.5540 | 1.0274 | 0.9752 | 1.8673 | |
| HCC1806 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7830.018 | uM | 0.0220 | 0.02315 | -0.0933 | -0.1447 | 5.0000 | 0.6445 | 0.9806 | 1.5320 | |
| HCC1806 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7450.065 | uM | 181.52970 | 394.91930 | -0.6252 | -0.6847 | 1.1098 | 0.5145 | 0.9954 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7451.065 | uM | 153.05320 | 257.03860 | -0.7378 | -0.7473 | 1.7633 | 0.5991 | 0.9967 | 2.1525 | |
| HCC1806 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 12239.157 | uM | 1.14210 | 1.21950 | -0.2021 | -0.1937 | 4.9993 | 0.4166 | 0.9965 | 2.0946 | |
| HCC1806 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14128.189 | uM | 1.43790 | 2.14480 | -0.5853 | -0.5895 | 1.9480 | 0.4731 | 0.9881 | 2.7793 |