Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7457.074 | uM | 0.02825 | 0.04933 | -0.8779 | -0.8651 | 1.8013 | 1.1873 | 0.9950 | 1.6514 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7456.074 | uM | 0.04929 | 0.07246 | -0.6875 | -0.6582 | 2.1806 | 1.0071 | 0.9962 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7456.074 | uM | 0.04929 | 0.07246 | -0.6875 | -0.6582 | 2.1806 | 1.0071 | 0.9962 | 1.9647 | |
| HCC1954 | HER2amp | Basal A | Bosutinib | Src | nRTK | 11055.145 | uM | 1.40170 | 4.24710 | -0.6601 | -0.8255 | 0.8794 | 0.4665 | 0.9842 | 1.7616 | |
| HCC1954 | HER2amp | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 9386.011 | uM | 46.51690 | 75.94480 | -0.6710 | -0.7021 | 1.7895 | 0.4257 | 0.9899 | 1.5229 | |
| HCC1954 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7837.042 | uM | inf | inf | 0.5276 | 0.5276 | 0.0000 | 0.1898 | -0.0281 | 1.6916 | |
| HCC1954 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7836.018 | uM | inf | inf | 0.4689 | 0.4689 | 0.0000 | 0.2364 | 0.1642 | 1.0819 | |
| HCC1954 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 9386.026 | uM | inf | 0.00908 | 0.6607 | 0.6679 | 0.8920 | 0.1146 | 0.8855 | 1.5583 | |
| HCC1954 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7835.018 | uM | 0.00137 | 0.00114 | 0.1067 | 0.3017 | 5.0000 | 0.3251 | 0.8954 | 0.5326 | |
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 9386.026 | uM | 1.40510 | 14.81740 | -0.8956 | -0.9802 | 0.4607 | 0.8841 | 0.9611 | 1.5583 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 7835.018 | uM | 0.10893 | 0.35289 | -1.0000 | -0.9136 | 0.8841 | 1.3946 | 0.9756 | 0.5326 | ||
| HCC1954 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 7836.018 | uM | 0.28194 | 3.02310 | -0.9716 | -1.0000 | 0.4631 | 1.1288 | 0.9773 | 1.0819 | ||
| HCC1954 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9386.017 | uM | 3.61380 | 7.99960 | -0.9042 | -0.8503 | 1.2502 | 0.4904 | 0.9929 | 1.3666 | |
| HCC1954 | HER2amp | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7837.017 | uM | 7.94730 | 15.57470 | -0.8874 | -0.9397 | 1.5719 | 0.4065 | 0.9933 | 1.4255 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 9386.121 | uM | 20.04580 | 33.29170 | -0.7778 | -1.0000 | 2.1657 | 0.1698 | 0.9898 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | CPT-11 | TOP1 | TOP | 7837.007 | uM | 17.2310 | 21.52140 | -0.6809 | -0.6943 | 3.9160 | 0.1331 | 0.9941 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Dactolisib | PI3K | PI3K | 11055.155 | uM | 0.05671 | 0.05684 | -0.0451 | -0.0034 | 2.8696 | 0.5091 | 0.9585 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Dichloroacetate | PDK | PDK | 13546.176 | uM | inf | inf | 0.8572 | 0.8572 | 0.0000 | 0.0835 | 0.4575 | 1.1206 | |
| HCC1954 | HER2amp | Basal A | Disulfiram | Proteasome | Proteasome | 13546.174 | uM | inf | inf | 0.8848 | 0.8848 | 0.0000 | 0.0417 | 0.4728 | 1.2035 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 7839.002 | uM | 0.00180 | 0.00316 | -0.4902 | -0.5019 | 1.2381 | 0.9442 | 0.9908 | 1.7009 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 7837.002 | uM | 0.00158 | 0.00326 | -0.6673 | -0.6961 | 1.2060 | 1.0562 | 0.9967 | 1.7373 | |
| HCC1954 | HER2amp | Basal A | Docetaxel | TUBB | TUBB | 9386.002 | uM | 0.00203 | 0.00415 | -0.7044 | -0.7066 | 1.2339 | 1.0324 | 0.9989 | 1.4405 | |
| HCC1954 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 7837.007 | uM | 0.18318 | 1.01540 | -0.9154 | -1.0000 | 0.6415 | 0.6945 | 0.9565 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Doxorubicin | TOP2 | TOP | 9386.121 | uM | 0.21132 | 0.44584 | -0.9518 | -0.8466 | 1.3270 | 0.7409 | 0.9948 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Epirubicin | TOP2 | TOP | 9386.017 | uM | 0.18301 | 0.55328 | -0.9624 | -0.9114 | 0.9379 | 0.8504 | 0.9903 | 1.3666 |