Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 7839.05 | uM | 0.03708 | 0.04845 | -0.4040 | -0.1375 | 0.9081 | 0.6437 | 0.9355 | 1.7470 | |
| HCC1954 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 7837.05 | uM | 0.03584 | 0.04824 | -0.5852 | -0.2882 | 1.5313 | 0.7574 | 0.9408 | 1.7172 | |
| HCC1954 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 9386.037 | uM | 0.02681 | 0.03564 | -0.6487 | -0.3895 | 2.0233 | 0.8282 | 0.9706 | 1.3556 | |
| HCC1954 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 7836.05 | uM | 0.05442 | 0.07004 | -0.7216 | -0.5172 | 2.8151 | 0.8537 | 0.9834 | 1.4789 | |
| HCC1954 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 11055.143 | uM | 147.76320 | 895.75930 | -0.2584 | -0.7499 | 0.5084 | 0.3133 | 0.9879 | 1.7215 | |
| HCC1954 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 7837.017 | uM | 21.57250 | 63.96340 | -0.5669 | -0.5580 | 0.6896 | 0.6860 | 0.9915 | 1.4255 | |
| HCC1954 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 9386.017 | uM | 16.03030 | 95.80030 | -0.6011 | -0.7103 | 0.4945 | 0.7125 | 0.9944 | 1.3666 | |
| HCC1954 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 11055.158 | uM | 0.15949 | 1.06990 | -0.8774 | -1.0000 | 0.5772 | 0.6563 | 0.9674 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7454.066 | uM | inf | inf | 0.7476 | 0.7476 | 0.0000 | 0.2337 | 0.0082 | 1.2748 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7455.066 | uM | inf | inf | 0.7337 | 0.7337 | 0.0000 | 0.0949 | 0.1979 | 1.2976 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 10469.066 | uM | inf | inf | 0.8043 | 0.8043 | 0.0000 | 0.0792 | 0.4011 | 1.6299 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7457.066 | uM | 50.65860 | 608.85770 | 0.5239 | -1.0000 | 0.4418 | 0.1204 | 0.7295 | 1.6601 | |
| HCC1954 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7456.066 | uM | 26.56080 | 15.38930 | 0.4525 | 0.2694 | 1.4177 | 0.0425 | 0.9797 | 1.7785 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7837.016 | uM | 0.77445 | 0.10184 | 0.2300 | 0.3001 | 0.4519 | 0.3972 | 0.6349 | 1.8067 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7839.016 | uM | 3.43060 | 13.99720 | -0.0508 | -0.3477 | 0.3754 | 0.3413 | 0.8640 | 1.5556 | |
| HCC1954 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7836.016 | uM | 3.92550 | 41.26260 | -0.3725 | -1.0000 | 0.4670 | 0.3500 | 0.9742 | 1.5669 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 11055.158 | uM | 4.55960 | 1.9540 | 0.3331 | 0.3627 | 1.5254 | 0.1752 | 0.9753 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 7454.072 | uM | inf | inf | 0.7579 | 0.7579 | 0.0000 | 0.1432 | -0.0206 | 1.3300 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 11055.072 | uM | inf | inf | 0.8354 | 0.8354 | 0.0000 | 0.0723 | 0.1965 | 1.7997 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 7455.072 | uM | inf | inf | 0.4213 | 0.4213 | 0.0000 | 0.2572 | 0.2782 | 1.1966 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 10469.072 | uM | 163.07630 | 145.90240 | 0.4813 | 0.1823 | 4.0746 | 0.0196 | 0.9331 | 1.3439 | |
| HCC1954 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 7456.073 | uM | 128.7210 | 98.23510 | 0.3989 | 0.2947 | 3.2924 | 0.0159 | 0.9731 | 1.8650 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14735.203 | uM | 0.00502 | 0.01163 | -0.8105 | -0.8285 | 1.1641 | 1.2463 | 0.9910 | 2.0496 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14735.203 | uM | 0.00502 | 0.01163 | -0.8105 | -0.8285 | 1.1641 | 1.2463 | 0.9910 | 2.0496 | |
| HCC1954 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7457.074 | uM | 0.02825 | 0.04933 | -0.8779 | -0.8651 | 1.8013 | 1.1873 | 0.9950 | 1.6514 |