Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7830.016 | uM | 5.83110 | 20.84310 | -0.2809 | -1.0000 | 0.8625 | 0.2416 | 0.8887 | 2.0313 | |
| HCC1806 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 9376.024 | uM | 5.89240 | 33.83110 | -0.0465 | -1.0000 | 0.6286 | 0.1926 | 0.9480 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7829.016 | uM | 5.65810 | 56.83570 | 0.0749 | -1.0000 | 0.4762 | 0.1818 | 0.9493 | 1.9532 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 9376.049 | uM | 0.45339 | 1.20540 | -0.1143 | -0.2675 | 0.4382 | 0.4463 | 0.8981 | 1.9229 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7829.04 | uM | 0.08871 | 0.17866 | -0.4305 | -0.3385 | 0.7385 | 0.6451 | 0.9710 | 1.9437 | |
| HCC1806 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 9376.024 | uM | 0.09105 | 0.16670 | -0.3874 | -0.3398 | 0.8574 | 0.6465 | 0.9817 | 1.7329 | |
| HCC1806 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 9376.011 | uM | 0.0020 | 0.00271 | -0.4566 | -0.3593 | 1.7705 | 1.1418 | 0.9864 | 1.5809 | |
| HCC1806 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7829.011 | uM | 0.00210 | 0.00301 | -0.5201 | -0.4810 | 1.8615 | 1.2324 | 0.9977 | 1.8746 | |
| HCC1806 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 12239.16 | uM | inf | 8.170 | 0.6981 | 0.6893 | 1.6228 | 0.0296 | 0.9372 | 1.8654 | ||
| HCC1806 | TNBC | Basal A | GM6001 | MMP | MMP | 7451.096 | uM | inf | 1000.00000 | 0.7959 | 0.3531 | 0.2465 | 0.0736 | 0.8243 | 2.1851 | |
| HCC1806 | TNBC | Basal A | GSK1070916 | AURK | AURK | 9376.001 | uM | 8.52810 | 15.2180 | -0.6314 | -1.0000 | 1.8970 | 0.1942 | 0.9775 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7451.091 | uM | 6.78910 | 7.13420 | -0.7375 | -0.1407 | 5.0000 | 0.3243 | 0.6889 | 2.1415 | |
| HCC1806 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7450.071 | uM | inf | 0.74442 | 0.9009 | 0.8991 | 4.9999 | 0.0233 | 0.8174 | 2.3612 | |
| HCC1806 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7450.098 | uM | inf | 6.96490 | 0.8269 | 0.8202 | 1.2453 | 0.0172 | 0.8654 | 2.2139 | |
| HCC1806 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7450.091 | uM | 10.05510 | 12.42230 | -0.9398 | -0.9367 | 4.9924 | 0.3214 | 0.9962 | 1.0419 | |
| HCC1806 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 9376.001 | uM | 0.01149 | 0.01275 | -0.8414 | -0.3412 | 5.0000 | 0.7692 | 0.90 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 9376.001 | uM | 0.04683 | 0.05049 | -0.2653 | -0.0881 | 2.1595 | 0.5459 | 0.9747 | 1.8315 | |
| HCC1806 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7451.088 | uM | inf | 49.38090 | 0.8865 | 0.5406 | 2.8264 | 0.0196 | 0.6068 | 2.0920 | |
| HCC1806 | TNBC | Basal A | Ibandronate | FDPS | 12239.143 | uM | 38.4330 | 59.03320 | -0.3065 | -0.3557 | 1.2519 | 0.3960 | 0.9762 | 2.1267 | ||
| HCC1806 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 12239.157 | uM | inf | 0.37078 | 0.6404 | 0.6618 | 0.8883 | 0.1335 | 0.9533 | 2.0946 | |
| HCC1806 | TNBC | Basal A | IKK16 | IKK | NFKB | 7451.093 | uM | 1.01580 | 1.59470 | -0.7628 | -0.7676 | 2.0624 | 0.5440 | 0.9965 | 2.1935 | |
| HCC1806 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7450.091 | uM | 45.88880 | 56.78120 | -0.9291 | -0.9503 | 5.0000 | 0.5062 | 0.6984 | 1.0419 | |
| HCC1806 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7451.091 | uM | 7.19530 | 11.54340 | -0.7850 | -0.7228 | 1.8918 | 0.5267 | 0.9959 | 2.1415 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7451.067 | uM | 0.03055 | 0.03510 | -0.7986 | -0.2490 | 2.9143 | 0.6372 | 0.8808 | 2.0570 | |
| HCC1806 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7450.067 | uM | 0.02270 | 0.02744 | -0.8269 | -0.3126 | 2.5604 | 0.6793 | 0.9054 | 2.2419 |