Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 10872.153 | uM | 46.92640 | 45.54350 | 0.8250 | 0.0654 | 4.6895 | 0.0111 | 0.5771 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 12523.165 | uM | 23.90660 | 71.77620 | 0.3581 | -1.0000 | 0.9993 | 0.0937 | 0.9340 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 7449.073 | uM | 115.50320 | 263.17120 | 0.2928 | -0.9999 | 1.3340 | 0.1071 | 0.9250 | 2.0567 | |
| HCC1569 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 10872.072 | uM | 146.69740 | 171.86820 | 0.2554 | -0.6037 | 5.0000 | 0.0598 | 0.9539 | 1.5765 | |
| HCC1569 | HER2amp | Basal A | Baicalein | Lipoxygenase | Metabolism | 10442.072 | uM | 48.89940 | 123.46680 | -0.1777 | -1.0000 | 1.1861 | 0.1487 | 0.9881 | 1.7484 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14727.203 | uM | 0.00487 | 0.00671 | -0.3979 | -0.4414 | 1.9793 | 1.0548 | 0.9842 | 1.7785 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 14727.203 | uM | 0.00487 | 0.00671 | -0.3979 | -0.4414 | 1.9793 | 1.0548 | 0.9842 | 1.7785 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7449.074 | uM | 0.04446 | 0.05185 | -0.5677 | -0.5797 | 5.0000 | 0.9942 | 0.9940 | 2.0321 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7449.074 | uM | 0.04446 | 0.05185 | -0.5677 | -0.5797 | 5.0000 | 0.9942 | 0.9940 | 2.0321 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7448.074 | uM | 0.04467 | 0.05224 | -0.2866 | -0.3169 | 3.1325 | 0.8357 | 0.9942 | 2.8830 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7448.074 | uM | 0.04467 | 0.05224 | -0.2866 | -0.3169 | 3.1325 | 0.8357 | 0.9942 | 2.8830 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7447.074 | uM | 0.03134 | 0.04745 | -0.6946 | -0.7204 | 2.1511 | 1.1027 | 0.9970 | 1.5411 | |
| HCC1569 | HER2amp | Basal A | Bortezomib | Proteasome | Proteasome | 7447.074 | uM | 0.03134 | 0.04745 | -0.6946 | -0.7204 | 2.1511 | 1.1027 | 0.9970 | 1.5411 | |
| HCC1569 | HER2amp | Basal A | Bosutinib | Src | nRTK | 12523.17 | uM | 1.52240 | 1.85070 | -0.3492 | -0.3531 | 2.7368 | 0.3173 | 0.9915 | 0.8990 | |
| HCC1569 | HER2amp | Basal A | Bosutinib | Src | nRTK | 10872.145 | uM | 1.75410 | 2.3020 | -0.3299 | -0.3077 | 1.7639 | 0.3878 | 0.9982 | 1.6308 | |
| HCC1569 | HER2amp | Basal A | Bromopyruvic acid | Hexokinase II | Metabolism | 13038.177 | uM | 0.03222 | 0.04006 | -0.9998 | -0.9847 | 5.0000 | 1.0779 | 0.9937 | 0.9161 | |
| HCC1569 | HER2amp | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7825.011 | uM | 76.95430 | 177.36430 | -0.4006 | -0.6024 | 0.9468 | 0.2728 | 0.9885 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 9347.011 | uM | 212.91210 | 298.64440 | -0.0049 | -0.2115 | 1.0427 | 0.1495 | 0.9926 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 9347.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0441 | -22.3629 | 1.2965 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7447.102 | uM | inf | inf | 0.9613 | 0.9613 | 0.0000 | 0.0386 | 0.0310 | 1.6467 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7825.018 | uM | inf | inf | 0.8711 | 0.8711 | 0.0000 | 0.0543 | 0.2924 | 1.9741 | |
| HCC1569 | HER2amp | Basal A | Cetuximab | EGFR | ErbB | 7824.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.3115 | |
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 7825.018 | uM | 55.48590 | 1000.00000 | -0.2561 | -0.6553 | 0.2896 | 0.3990 | 0.8041 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 9347.026 | uM | 179.50790 | 1000.00000 | -0.3117 | -0.6360 | 0.4778 | 0.3117 | 0.8790 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 7824.018 | uM | 282.40430 | 1000.00000 | -0.1818 | -0.5445 | 0.5826 | 0.2617 | 0.9528 | 1.3115 |