Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7444.065 | uM | 33.18170 | 51.07220 | -0.9931 | -0.9934 | 2.5373 | 0.9014 | 0.9995 | 0.7419 | |
| HCC1428 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 11936.157 | uM | 1.30930 | 1.17550 | 0.2690 | 0.2084 | 5.0000 | 0.3632 | 0.8620 | 0.9133 | |
| HCC1428 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10693.151 | uM | 1.43220 | 0.96658 | 0.3675 | 0.3784 | 3.5950 | 0.2677 | 0.9591 | 0.9475 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 11936.16 | uM | inf | inf | 0.3250 | 0.3250 | 0.0000 | 0.2837 | 0.5167 | 0.8962 | |
| HCC1428 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10693.15 | uM | 6.71360 | 20.13110 | -0.2575 | -1.0000 | 1.0004 | 0.1570 | 0.9873 | 0.7763 | |
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 9347.132 | uM | inf | inf | 0.9658 | 0.9658 | 0.0000 | 0.0420 | 0.0572 | 1.4716 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7827.016 | uM | inf | inf | 0.7012 | 0.7012 | 0.0000 | 0.2058 | 0.4015 | 1.4950 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7824.016 | uM | inf | inf | -0.0307 | -0.0307 | 0.0000 | 0.2301 | 0.520 | 1.7164 | ||
| HCC1569 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7825.016 | uM | inf | 1.82670 | 0.5837 | 0.7015 | 0.8448 | 0.1342 | 0.5923 | 1.6601 | ||
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 7825.05 | uM | 0.19710 | 0.29708 | -0.4272 | -0.2349 | 0.9388 | 0.5258 | 0.9530 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 9347.037 | uM | 0.14895 | 0.26760 | -0.4151 | -0.3269 | 0.8586 | 0.5965 | 0.9831 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 2-deoxyglucose | 13038.177 | uM | 469.81210 | 479.04620 | -0.0506 | -0.0511 | 4.9998 | 0.1354 | 0.9891 | 0.9161 | |||
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 12523.143 | uM | 445.02050 | 1000.00000 | 0.1011 | -0.2057 | 0.4255 | 0.2304 | 0.9370 | 0.9700 | |
| HCC1569 | HER2amp | Basal A | 5-DFUR | TYMS | TYMS | 10872.143 | uM | 377.42770 | 1000.00000 | 0.0754 | -0.3195 | 0.5071 | 0.2513 | 0.9868 | 1.6364 | |
| HCC1569 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 9347.017 | uM | 150.85050 | 686.85660 | -0.3774 | -0.6024 | 0.5216 | 0.4393 | 0.9886 | 1.6249 | |
| HCC1569 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 7824.017 | uM | 202.61720 | 1000.00000 | -0.3571 | -0.6276 | 0.5094 | 0.4271 | 0.9930 | 1.6694 | |
| HCC1569 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 7825.017 | uM | 66.7090 | 350.70450 | -0.2852 | -0.5028 | 0.4193 | 0.5023 | 0.9935 | 2.0855 | |
| HCC1569 | HER2amp | Basal A | Afatinib | EGFR/HER2 | ErbB | 12523.165 | uM | 0.24225 | 3.08050 | -0.9551 | -1.0000 | 0.4320 | 0.5528 | 0.9045 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7447.066 | uM | inf | inf | 0.9240 | 0.9240 | 0.0000 | -0.0284 | 0.0463 | 1.5813 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7449.066 | uM | inf | inf | 0.9561 | 0.9561 | 0.0000 | 0.0074 | 0.4565 | 1.9622 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 7448.066 | uM | inf | inf | 0.8727 | 0.8727 | 0.0000 | 0.0287 | 0.5144 | 2.7001 | |
| HCC1569 | HER2amp | Basal A | AG1024 | IGF1R | RTK | 10442.066 | uM | 38.67510 | 37.4940 | 0.5789 | 0.0330 | 2.2024 | 0.0250 | 0.9630 | 1.6519 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7825.016 | uM | 6.01080 | 1.3460 | 0.3243 | 0.4469 | 1.4982 | 0.2169 | 0.8947 | 1.6601 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7827.016 | uM | 5.07820 | 86.92810 | -0.1931 | -1.0000 | 0.3868 | 0.3527 | 0.9348 | 1.4950 | |
| HCC1569 | HER2amp | Basal A | AG1478 | EGFR | ErbB | 7824.016 | uM | 6.10490 | 12.64480 | -0.1925 | -0.3733 | 0.7659 | 0.3219 | 0.9839 | 1.7164 |