Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10019.002 | uM | 0.47272 | 1.90670 | 0.0482 | -0.3033 | 0.3399 | 0.3675 | 0.7925 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 7820.002 | uM | inf | 0.08606 | 0.5386 | 0.5839 | 1.7167 | 0.1863 | 0.9537 | 0.7084 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9278.002 | uM | 0.01066 | 0.01155 | -0.1724 | -0.1112 | 2.4854 | 0.6705 | 0.9946 | 0.3717 | |
| HCC1419 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 12001.159 | uM | 1.03140 | 1.66660 | -0.6261 | -0.6522 | 1.7397 | 0.4539 | 0.9650 | 0.7107 | |
| HCC1419 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12001.135 | uM | 61.02570 | 399.23630 | 0.3031 | -1.0000 | 0.5849 | 0.1733 | 0.6335 | 0.4442 | |
| HCC1419 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12001.168 | uM | 0.02662 | 0.04483 | -0.9997 | -0.4264 | 1.1833 | 0.8384 | 0.8693 | 0.4934 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7821.007 | uM | 0.07222 | 0.44860 | -0.8992 | -1.0000 | 0.6015 | 0.9500 | 0.8835 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9278.121 | uM | 0.50748 | 0.89679 | -0.9124 | -0.9014 | 1.8101 | 0.7330 | 0.9906 | 0.4498 | |
| HCC1419 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7820.007 | uM | 0.25592 | 0.59124 | -0.8241 | -0.8423 | 1.1793 | 0.7347 | 0.9980 | 0.6838 | |
| HCC1419 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12001.169 | uM | 12.67240 | 39.29830 | -0.4704 | -1.0000 | 0.9707 | 0.2832 | 0.9276 | 0.7194 | |
| HCC1419 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 7437.093 | uM | inf | 8.68660 | 0.6973 | 0.6972 | 4.7687 | 0.0816 | 0.6513 | 0.4731 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7818.05 | uM | 6.20090 | 0.00082 | 0.3938 | 0.4924 | 0.4692 | 0.3679 | 0.6443 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7820.05 | uM | 0.01530 | 0.00593 | 0.2545 | 0.3401 | 1.2031 | 0.4101 | 0.8544 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9278.012 | uM | 0.24398 | 0.34956 | -0.0252 | -0.0886 | 0.4539 | 0.3283 | 0.8848 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7821.05 | uM | 0.02098 | 0.00978 | 0.1172 | 0.2061 | 0.6959 | 0.4452 | 0.9682 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 10019.124 | uM | 8.22850 | 7.66340 | 0.6382 | 0.1473 | 4.9063 | 0.0323 | 0.6853 | 0.5356 | |
| HCC1419 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9278.026 | uM | 0.34018 | 65.36710 | 0.0640 | -1.0000 | 0.2089 | 0.3320 | 0.7476 | 0.3395 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7440.065 | uM | 14.26460 | 31.9150 | -0.9963 | -1.0000 | 1.3642 | 0.8657 | 0.9813 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7437.065 | uM | 11.93920 | 23.41830 | -0.9962 | -1.0000 | 1.6307 | 0.8694 | 0.9942 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Triciribine | AKT | AKT | 7440.074 | uM | 0.09929 | 2.40420 | -0.4308 | -1.0000 | 0.3447 | 0.5626 | 0.9620 | 0.4778 | |
| HCC1419 | HER2amp | Luminal | Triciribine | AKT | AKT | 7437.074 | uM | 0.23997 | 0.80705 | -0.4863 | -0.6212 | 0.6658 | 0.4591 | 0.9812 | 0.3747 | |
| HCC1419 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12001.143 | uM | 483.23550 | 1000.00000 | -0.9717 | -0.7114 | 1.2168 | 0.3901 | 0.8615 | 0.6160 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7818.018 | uM | 0.33258 | 4.20580 | -0.9652 | -1.0000 | 0.4330 | 0.5096 | 0.8139 | 0.9928 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7820.042 | uM | 0.01058 | 0.45734 | -0.9993 | -1.0000 | 0.2917 | 0.7971 | 0.8795 | 0.5216 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7821.042 | uM | 0.01313 | 0.37822 | -0.9983 | -1.0000 | 0.3269 | 0.7907 | 0.8861 | 0.5522 |