Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7458.067 | uM | 86.46050 | 338.88380 | 0.2696 | -1.0000 | 0.8043 | 0.1012 | 0.8969 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7841.068 | uM | 0.00121 | 0.11539 | -0.9987 | -1.0000 | 0.2410 | 1.0741 | 0.8833 | 0.6440 | |
| HCC202 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7840.068 | uM | 0.00955 | 0.01046 | -0.4394 | -0.2887 | 5.0000 | 0.9750 | 0.9397 | 0.3749 | |
| HCC202 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7458.069 | uM | 0.00492 | 0.00713 | -0.3473 | -0.2539 | 1.1089 | 0.8100 | 0.9880 | 0.4444 | |
| HCC202 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7458.084 | uM | 47.30310 | 146.2190 | -0.9279 | -1.0000 | 0.9735 | 0.3150 | 0.9667 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7458.067 | uM | 8.10020 | 10.09110 | -1.0000 | -1.0000 | 4.9990 | 0.4032 | 0.9968 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Taxol | TUBB | TUBB | 7844.002 | uM | 0.00654 | 0.01663 | -0.4659 | -0.4332 | 0.6686 | 0.8675 | 0.9544 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7841.077 | uM | 0.24293 | 1.88340 | -0.8353 | -1.0000 | 0.5364 | 0.6924 | 0.9648 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7844.012 | uM | 0.88217 | 230.24550 | 0.2660 | -1.0000 | 0.1974 | 0.3290 | 0.6853 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7840.05 | uM | inf | 0.00228 | 0.3658 | 0.6091 | 4.9825 | 0.2416 | 0.7250 | 0.4666 | |
| HCC202 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7458.065 | uM | 0.92043 | 1.63230 | -0.9995 | -1.0000 | 1.9177 | 1.2766 | 0.9965 | 0.4917 | |
| HCC202 | HER2amp | Luminal | Triciribine | AKT | AKT | 7458.074 | uM | 0.02409 | 0.04816 | -0.9605 | -0.8085 | 1.3885 | 0.9029 | 0.9881 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7840.018 | uM | 0.01143 | 0.02312 | -0.9979 | -0.6752 | 1.2125 | 0.9535 | 0.9512 | 0.4113 | |
| HCC202 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7458.065 | uM | 18.63560 | 30.24950 | -0.9998 | -1.0000 | 2.2680 | 1.0058 | 0.9950 | 0.4917 | |
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9420.132 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0075 | -0.0001 | 0.3309 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7846.016 | uM | 6.79370 | 6.48310 | -0.3064 | 0.1043 | 5.0000 | 0.3414 | 0.5784 | 0.3279 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7845.016 | uM | 26.42820 | 1.11560 | 0.3882 | 0.2272 | 0.1914 | 0.3503 | 0.5905 | 0.4392 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7849.016 | uM | 8.93180 | 7.17820 | -0.0960 | 0.3324 | 5.0000 | 0.2075 | 0.5971 | 0.3419 | ||
| HCC2185 | TNBC | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7848.016 | uM | 134.10220 | 292.98580 | 0.3729 | -1.0000 | 1.4057 | 0.0584 | 0.9150 | 0.4818 | ||
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 7845.05 | uM | 0.07743 | 0.10419 | -0.9714 | -0.8097 | 3.2437 | 1.0531 | 0.9479 | 0.4747 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 7846.05 | uM | 0.06713 | 0.09888 | -0.8984 | -0.8837 | 2.6285 | 1.0839 | 0.9760 | 0.3833 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 9420.037 | uM | 0.07080 | 0.10739 | -0.9778 | -0.8569 | 2.3960 | 0.9873 | 0.9872 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 7848.05 | uM | 0.10358 | 0.18018 | -0.9498 | -0.8388 | 1.7790 | 0.8729 | 0.9930 | 0.4413 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 7848.037 | uM | 0.15066 | 0.26859 | -0.8155 | -0.7911 | 1.6409 | 0.8044 | 0.9954 | 0.4916 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 7849.04 | uM | 0.14742 | 0.17890 | -0.8775 | -0.8162 | 5.0000 | 0.8687 | 0.9963 | 0.5448 |