Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9402.001 | uM | inf | inf | -0.3808 | -0.3808 | 0.0000 | 0.7597 | 0.4856 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7844.001 | uM | 0.06390 | 2.53280 | -0.7770 | -1.0000 | 0.2986 | 0.6191 | 0.6516 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7841.001 | uM | 0.79392 | 5.23960 | -0.7802 | -1.0000 | 0.5822 | 0.4422 | 0.8602 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7458.091 | uM | inf | inf | 1.0005 | 1.0005 | 0.0000 | 0.1959 | 0.0969 | 0.5499 | |
| HCC202 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7458.098 | uM | 7.23870 | 10.49390 | -0.9992 | -1.0000 | 2.9584 | 0.3027 | 0.9966 | 0.5731 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7844.001 | uM | inf | inf | -0.9997 | -0.9997 | 0.0000 | 0.8273 | 0.4411 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7841.001 | uM | 0.00065 | 0.00073 | -0.7519 | -0.1312 | 2.0815 | 0.9082 | 0.6730 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9402.001 | uM | 0.00002 | 0.09136 | -0.5692 | -1.0000 | 0.1320 | 0.9532 | 0.7655 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9402.001 | uM | inf | inf | -0.3335 | -0.3335 | 0.0000 | 0.8864 | 0.0187 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7844.001 | uM | 0.03286 | 0.04068 | -0.8899 | -0.5598 | 3.5183 | 0.9169 | 0.8332 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7841.001 | uM | 0.01301 | 0.02246 | -0.8239 | -0.5382 | 1.3390 | 0.8798 | 0.9226 | 0.5424 | |
| HCC202 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7458.091 | uM | 8.85040 | 19.21130 | -0.9997 | -1.0000 | 1.4175 | 0.5855 | 0.9822 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 7458.067 | uM | 0.00782 | 0.01292 | -0.9999 | -0.8837 | 2.0273 | 1.1391 | 0.9926 | 0.5714 | |
| HCC202 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 7458.095 | uM | 0.00675 | 0.01005 | -1.0000 | -0.9159 | 2.6174 | 1.2208 | 0.9968 | 0.3752 | |
| HCC202 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7458.098 | uM | 0.62048 | 0.94076 | -0.4683 | -0.5221 | 1.7180 | 0.3560 | 0.9881 | 0.5731 | |
| HCC202 | HER2amp | Luminal | Mebendazole | 13135.174 | uM | 0.11984 | 0.16702 | -0.1968 | -0.1744 | 0.9014 | 0.6176 | 0.8593 | 0.5256 | |||
| HCC202 | HER2amp | Luminal | Methotrexate | DHFR | Metabolism | 7458.084 | uM | 0.01764 | 0.01325 | 0.3662 | 0.3805 | 5.0000 | 0.4979 | 0.9697 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Nelfinavir | 13135.174 | uM | 4.33360 | 7.98070 | -0.9853 | -1.0000 | 1.7991 | 0.4064 | 0.8752 | 0.5256 | |||
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 7458.066 | uM | 9.44250 | 20.29110 | -0.7543 | -1.0000 | 1.4362 | 0.2773 | 0.9137 | 0.3722 | |
| HCC202 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 10470.066 | uM | 32.95840 | 41.05730 | -0.8403 | -1.0000 | 5.0000 | 0.1379 | 0.9833 | 0.4712 | |
| HCC202 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 10470.087 | uM | 0.00098 | 0.00256 | -0.9996 | -1.0000 | 1.1390 | 1.4830 | 0.9905 | 0.3641 | |
| HCC202 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7841.075 | uM | 2.98530 | 11.97450 | -0.9983 | -1.0000 | 0.7909 | 0.6956 | 0.9498 | 0.5408 | |
| HCC202 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9402.011 | uM | 6.61380 | 14.3430 | -1.0000 | -1.0000 | 1.4192 | 0.6199 | 0.9835 | 0.3388 | |
| HCC202 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7458.095 | uM | 0.01613 | 0.02380 | -0.3116 | -0.1907 | 0.8308 | 1.0611 | 0.8348 | 0.3752 | |
| HCC202 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7458.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0275 | -0.6310 | 0.4917 |