Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Taxol | TUBB | TUBB | 10262.002 | uM | 0.01348 | 0.01656 | -0.4597 | -0.1999 | 1.6313 | 0.6733 | 0.9646 | 0.6356 | |
| HCC1937 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 11849.159 | uM | 0.28149 | 0.62865 | -0.6881 | -0.6490 | 1.0355 | 0.5315 | 0.9877 | 1.2484 | |
| HCC1937 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 11849.135 | uM | inf | 34.3620 | 0.6252 | 0.6247 | 4.9967 | 0.0362 | 0.8713 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 11849.144 | uM | 0.59297 | 43.24630 | -0.4246 | -1.0000 | 0.2561 | 0.4841 | 0.8431 | 1.4131 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7833.007 | uM | 0.12484 | 0.23013 | -0.3775 | -0.4609 | 1.0681 | 0.7226 | 0.9633 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11849.16 | uM | 7.96010 | 19.76960 | -0.3426 | -1.0000 | 1.2077 | 0.1868 | 0.9374 | 1.2119 | |
| HCC1937 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 7453.093 | uM | inf | 3.94890 | 0.5333 | 0.5945 | 5.0000 | 0.0716 | 0.9292 | 1.5872 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 10262.012 | uM | inf | inf | 0.2614 | 0.2614 | 0.0000 | 0.2012 | 0.480 | 0.5802 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 7832.036 | uM | inf | 0.12078 | 0.5478 | 0.6236 | 4.9985 | 0.1810 | 0.8122 | 1.2817 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 7833.05 | uM | inf | 0.01839 | 0.6470 | 0.6103 | 0.6609 | 0.2068 | 0.8885 | 1.1523 | |
| HCC1937 | TNBC | Basal A | Trametinib | MEK | MAPK | 7834.05 | uM | inf | 999.99010 | 0.6256 | -0.1103 | 0.1775 | 0.1664 | 0.9053 | 1.9027 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 7453.065 | uM | 15.17890 | 33.30370 | -0.7504 | -0.6754 | 1.0878 | 0.6336 | 0.9924 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Triciribine | AKT | AKT | 7453.074 | uM | 13.45240 | 3.36860 | 0.4128 | 0.3099 | 0.6986 | 0.1200 | 0.9719 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Triciribine | AKT | AKT | 7452.074 | uM | 11.71590 | 3.05490 | 0.4011 | 0.3068 | 0.7075 | 0.1258 | 0.9737 | 1.5162 | |
| HCC1937 | TNBC | Basal A | Valproic acid | HDAC | HDAC | 11849.143 | uM | 755.07480 | 1000.00000 | -0.7549 | -0.2437 | 1.4133 | 0.1864 | 0.7489 | 1.3433 | |
| HCC1937 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7832.042 | uM | 0.56363 | 7.51120 | -0.9109 | -1.0000 | 0.4242 | 0.4635 | 0.7073 | 1.2810 | |
| HCC1937 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7834.018 | uM | 0.42948 | 8.60030 | -0.7314 | -1.0000 | 0.3666 | 0.4280 | 0.7679 | 1.8951 | |
| HCC1937 | TNBC | Basal A | Vinorelbine | TUBB | TUBB | 7833.042 | uM | 0.16261 | 2.95960 | -0.9198 | -1.0000 | 0.3786 | 0.5343 | 0.8323 | 1.0332 | |
| HCC1937 | TNBC | Basal A | Vorinostat | HDAC | HDAC | 7453.065 | uM | 195.40680 | 353.64710 | -0.3863 | -0.4217 | 1.0310 | 0.4348 | 0.9984 | 1.6649 | |
| HCC1937 | TNBC | Basal A | XRP44X | ELK3 | MAPK | 11849.157 | uM | inf | 4.07330 | 0.6796 | 0.7115 | 4.9999 | 0.1061 | 0.6462 | 1.4559 | |
| HCC1937 | TNBC | Basal A | ZM-447439 | AURK | AURK | 11849.16 | uM | 6.03160 | 3.74180 | 0.2428 | 0.1660 | 0.8452 | 0.2388 | 0.9376 | 1.2119 | |
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 9386.132 | uM | inf | inf | 0.8888 | 0.8888 | 0.0000 | 0.0599 | 0.2243 | 1.4083 | ||
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7839.016 | uM | 11.14970 | 9.36220 | -0.0928 | 0.2913 | 5.0000 | 0.1435 | 0.7301 | 1.5556 | ||
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7837.016 | uM | inf | 0.10883 | 0.5673 | 0.5502 | 0.4362 | 0.2557 | 0.8660 | 1.8067 | ||
| HCC1954 | HER2amp | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7836.016 | uM | 33.93490 | 143.9580 | -0.0804 | -1.0000 | 0.7602 | 0.1638 | 0.9872 | 1.5669 |