Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7452.066 | uM | 29.47080 | 58.06260 | -0.1140 | -1.0000 | 1.6201 | 0.1213 | 0.9753 | 1.4723 | |
| HCC1937 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7453.066 | uM | 19.2410 | 18.05470 | 0.1353 | 0.1339 | 4.8969 | 0.0485 | 0.9855 | 1.3901 | |
| HCC1937 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 11849.147 | uM | 7.96540 | 8.91870 | -0.2658 | -0.2648 | 3.7594 | 0.2354 | 0.9962 | 1.3461 | |
| HCC1937 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7453.086 | uM | 0.03125 | 0.07221 | -0.4222 | -0.3479 | 0.6306 | 0.6303 | 0.9877 | 1.4238 | |
| HCC1937 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7832.011 | uM | 2.9990 | 23.37050 | -0.7894 | -1.0000 | 0.5351 | 0.5793 | 0.9709 | 1.4385 | |
| HCC1937 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7834.075 | uM | 11.99920 | 70.62470 | -0.4847 | -0.9291 | 0.5925 | 0.3917 | 0.9881 | 2.0182 | |
| HCC1937 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10262.021 | uM | 10.13520 | 27.94670 | -0.9380 | -1.0000 | 1.0831 | 0.4678 | 0.9912 | 0.6806 | |
| HCC1937 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 11849.147 | uM | 1.80720 | 3.47010 | -0.8976 | -0.9698 | 1.6528 | 0.4724 | 0.9912 | 1.3461 | |
| HCC1937 | TNBC | Basal A | PD 98059 | MEK | MAPK | 11849.159 | uM | 32.36610 | 1000.00000 | 0.3158 | -0.6741 | 0.2488 | 0.2308 | 0.8570 | 1.2484 | |
| HCC1937 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7453.093 | uM | 7.77590 | 8.10660 | -0.1145 | -0.1155 | 4.9896 | 0.0831 | 0.9926 | 1.5872 | |
| HCC1937 | TNBC | Basal A | PD184352 | MEK | MAPK | 11849.155 | uM | inf | 998.67740 | 0.8103 | 0.5512 | 0.1317 | 0.0991 | 0.6028 | 1.4975 | |
| HCC1937 | TNBC | Basal A | PD184352 | MEK | MAPK | 11849.155 | uM | inf | 998.67740 | 0.8103 | 0.5512 | 0.1317 | 0.0991 | 0.6028 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7453.095 | uM | inf | inf | 0.9591 | 0.9591 | 0.0000 | 0.0882 | 0.1205 | 1.6395 | |
| HCC1937 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7452.095 | uM | inf | inf | 0.4951 | 0.4951 | 0.0000 | 0.0433 | 0.3803 | 1.7316 | |
| HCC1937 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7453.065 | uM | inf | inf | 0.8929 | 0.8929 | 0.0000 | 0.0272 | 0.2991 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7453.067 | uM | inf | inf | 1.0249 | 1.0249 | 0.0000 | -0.0351 | -2.6870 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7452.067 | uM | 16.91250 | 10.82620 | 0.3707 | 0.4463 | 5.0000 | 0.1121 | 0.9632 | 1.7112 | |
| HCC1937 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 11849.144 | uM | inf | 23.07470 | 0.6766 | 0.6764 | 4.9727 | 0.0269 | 0.8728 | 1.4131 | |
| HCC1937 | TNBC | Basal A | Selumetinib | MEK | MAPK | 11849.155 | uM | inf | 0.09005 | 0.8273 | 0.8288 | 1.0107 | 0.0792 | 0.8095 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 11849.158 | uM | 11.40840 | 18.59730 | -0.9207 | -1.0000 | 2.2482 | 0.2623 | 0.9849 | 1.4054 | |
| HCC1937 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7834.068 | uM | 2.71990 | 54.52920 | -0.5448 | -1.0000 | 0.3664 | 0.4095 | 0.7935 | 2.0420 | |
| HCC1937 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7453.084 | uM | inf | inf | 1.0008 | 1.0008 | 0.0000 | -0.0055 | -0.0025 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7452.084 | uM | 21.00610 | 32.1780 | -0.8452 | -0.6562 | 1.9656 | 0.4290 | 0.9750 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7453.067 | uM | inf | inf | -0.8500 | -0.8500 | 0.0000 | 0.2391 | 0.4179 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7452.067 | uM | 6.77240 | 10.4640 | -0.9429 | -0.9418 | 2.4342 | 0.4021 | 0.9993 | 1.7112 |