Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | ICRF-193 | TOP2 | TOP | 11849.157 | uM | inf | inf | 0.7560 | 0.7560 | 0.0000 | 0.1057 | 0.3086 | 1.4559 | |
| HCC1937 | TNBC | Basal A | IKK16 | IKK | NFKB | 7453.093 | uM | 2.52090 | 3.43340 | -0.9072 | -0.8973 | 3.3269 | 0.3937 | 0.9976 | 1.5872 | |
| HCC1937 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7453.091 | uM | 21.68510 | 32.09540 | -0.9340 | -0.9418 | 2.7010 | 0.4583 | 0.9972 | 1.5914 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7452.067 | uM | 0.36718 | 2.15560 | -0.9148 | -1.0000 | 0.6207 | 0.4863 | 0.9435 | 1.7112 | |
| HCC1937 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 7453.067 | uM | 0.49351 | 2.30660 | -0.9441 | -1.0000 | 0.7125 | 0.4479 | 0.9554 | 1.5080 | |
| HCC1937 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7453.095 | uM | 0.09315 | 3.02390 | -0.9133 | -1.0000 | 0.3157 | 0.5409 | 0.7409 | 1.6395 | |
| HCC1937 | TNBC | Basal A | Ixabepilone | TUBB | TUBB | 7452.095 | uM | 0.53562 | 0.75487 | -0.8571 | -0.8566 | 2.9091 | 0.5528 | 0.9986 | 1.7316 | |
| HCC1937 | TNBC | Basal A | JNK-IN-5A | JNK | JNK | 11849.144 | uM | inf | inf | 0.6314 | 0.6314 | 0.0000 | 0.0592 | 0.5017 | 1.4131 | |
| HCC1937 | TNBC | Basal A | L-779450 | BRAF | MAPK | 11849.161 | uM | 30.43390 | 37.91230 | -0.5996 | -1.0000 | 5.0000 | 0.0531 | 0.9916 | 1.2764 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7453.098 | uM | inf | inf | 0.9252 | 0.9252 | 0.0000 | 0.0007 | 0.1372 | 1.4660 | |
| HCC1937 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 7452.098 | uM | inf | 9.96550 | 0.8503 | 0.7591 | 0.9473 | 0.0022 | 0.7737 | 1.6799 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 11849.154 | uM | 0.18567 | 0.35457 | -0.7180 | -0.6832 | 1.3315 | 0.5922 | 0.9911 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11849.154 | uM | 0.65930 | 2.40320 | -0.8887 | -1.0000 | 0.8494 | 0.4267 | 0.9939 | 1.1927 | |
| HCC1937 | TNBC | Basal A | Mebendazole | 13115.174 | uM | 3.84060 | 1.74080 | 0.2960 | 0.4159 | 2.2527 | 0.1651 | 0.9403 | 0.8122 | |||
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7452.084 | uM | inf | inf | 0.9680 | 0.9680 | 0.0000 | -0.0014 | 0.1350 | 1.6800 | |
| HCC1937 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7453.084 | uM | inf | 7.75030 | 0.9502 | 0.9560 | 4.9953 | 0.0060 | 0.5997 | 1.5592 | |
| HCC1937 | TNBC | Basal A | Methylglyoxal | 13115.184 | uM | 104.30230 | 312.93630 | -0.9999 | -1.0000 | 0.9999 | 0.8492 | 0.9661 | 0.7929 | |||
| HCC1937 | TNBC | Basal A | Methylglyoxal | 13177.184 | uM | 504.29230 | 687.61710 | -1.0000 | -1.0000 | 3.5430 | 0.6770 | 0.9873 | 0.3394 | |||
| HCC1937 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 11849.145 | uM | 0.13365 | 0.16967 | -0.8677 | -0.8553 | 4.1787 | 0.8372 | 0.9991 | 1.5253 | |
| HCC1937 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 11849.145 | uM | 0.13365 | 0.16967 | -0.8677 | -0.8553 | 4.1787 | 0.8372 | 0.9991 | 1.5253 | |
| HCC1937 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 11849.135 | uM | 6.13190 | 3.37530 | 0.3368 | 0.0975 | 0.3635 | 0.2657 | 0.9023 | 1.4337 | |
| HCC1937 | TNBC | Basal A | Nelfinavir | 13115.174 | uM | 6.86140 | 8.82710 | -0.9981 | -1.0000 | 4.3611 | 0.1920 | 0.9948 | 0.8122 | |||
| HCC1937 | TNBC | Basal A | Nilotinib | ABL | nRTK | 11849.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0324 | 0.0000 | 1.5253 | |
| HCC1937 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 11849.159 | uM | 0.99033 | 1.87210 | -0.9671 | -0.9997 | 1.7249 | 0.7658 | 0.9825 | 1.2484 | |
| HCC1937 | TNBC | Basal A | NU6102 | CDK1/2 | CDK | 11849.147 | uM | 46.87540 | 58.30410 | -0.3167 | -0.9885 | 5.0000 | 0.0811 | 0.9931 | 1.3461 |