Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7840.05 | uM | 0.03649 | 0.05467 | -0.9461 | -0.7311 | 2.2284 | 1.0056 | 0.9789 | 0.4666 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7458.066 | uM | 27.10580 | 214.79750 | 0.4470 | -1.0000 | 0.5307 | 0.1129 | 0.6574 | 0.3722 | |
| HCC202 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 10470.066 | uM | 11.30580 | 5.29010 | 0.3828 | 0.3504 | 1.5889 | 0.0953 | 0.9382 | 0.4712 | |
| HCC202 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7840.016 | uM | 0.37479 | 2.60310 | -0.8120 | -0.8095 | 0.4968 | 0.6474 | 0.8814 | 0.4918 | |
| HCC202 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7841.016 | uM | 1.37970 | 3.90690 | -0.8994 | -0.9430 | 1.0182 | 0.6093 | 0.9610 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Baicalein | Lipoxygenase | Metabolism | 10470.072 | uM | 55.75220 | 80.06650 | -0.8066 | -1.0000 | 3.0353 | 0.1418 | 0.9823 | 0.3299 | |
| HCC202 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7458.074 | uM | 0.02143 | 0.02670 | -0.9999 | -1.0000 | 5.0000 | 1.3545 | 0.9987 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7458.074 | uM | 0.02143 | 0.02670 | -0.9999 | -1.0000 | 5.0000 | 1.3545 | 0.9987 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7841.075 | uM | 45.47320 | 56.40970 | -0.9960 | -0.9663 | 4.9921 | 0.5164 | 0.9828 | 0.5408 | |
| HCC202 | HER2amp | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9402.011 | uM | 12.39070 | 28.91960 | -1.0000 | -0.9999 | 1.2961 | 0.5834 | 0.9942 | 0.3388 | |
| HCC202 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7840.018 | uM | inf | inf | 0.3680 | 0.3680 | 0.0000 | 0.1308 | 0.1949 | 0.4113 | |
| HCC202 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 7840.018 | uM | 0.76927 | 21.16950 | -1.0000 | -1.0000 | 0.3314 | 0.8747 | 0.8389 | 0.4113 | ||
| HCC202 | HER2amp | Luminal | CPT-11 | TOP1 | TOP | 7841.077 | uM | 17.65350 | 19.80220 | -0.3854 | -0.3864 | 4.9848 | 0.2329 | 0.8131 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13135.176 | uM | 5.15650 | 270.40390 | 0.4671 | -1.0000 | 0.2775 | 0.1576 | 0.6760 | 0.3972 | |
| HCC202 | HER2amp | Luminal | Disulfiram | Proteasome | Proteasome | 13135.174 | uM | inf | inf | -0.5009 | -0.5009 | 0.0000 | 0.5075 | 0.5614 | 0.5256 | |
| HCC202 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 7844.002 | uM | 0.00427 | 0.00872 | -0.5023 | -0.4321 | 0.8713 | 0.8046 | 0.9625 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7841.077 | uM | 0.2090 | 0.47453 | -0.9999 | -1.0000 | 1.3398 | 0.8939 | 0.9749 | 0.4474 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 7458.091 | uM | 29.90550 | 60.91930 | -0.0727 | -1.0000 | 1.5441 | 0.1436 | 0.9574 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 7458.074 | uM | 0.79469 | 1.9120 | -0.8265 | -0.8022 | 1.0902 | 0.7102 | 0.9948 | 0.4138 | |
| HCC202 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 7458.084 | uM | 0.04316 | 0.06479 | -0.9999 | -1.0000 | 2.7039 | 0.9772 | 0.9974 | 0.5653 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7840.016 | uM | 0.39858 | 2.67870 | -0.8099 | -1.0000 | 0.5767 | 0.5229 | 0.9183 | 0.4918 | |
| HCC202 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7841.016 | uM | 1.13560 | 3.3470 | -0.9331 | -1.0000 | 1.0164 | 0.3727 | 0.9810 | 0.4493 | |
| HCC202 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 7844.012 | uM | 0.01164 | 0.02235 | -0.7583 | -0.6702 | 1.3028 | 1.1045 | 0.9814 | 0.4416 | |
| HCC202 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 7841.075 | uM | 4.29240 | 783.87230 | -0.1055 | -1.0000 | 0.2110 | 0.4493 | 0.7191 | 0.5408 | |
| HCC202 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9402.011 | uM | 14.71040 | 18.67330 | -0.1552 | -0.2098 | 1.4687 | 0.1622 | 0.9893 | 0.3388 |