Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7846.068 | uM | 0.00132 | 0.00221 | -0.5384 | -0.3084 | 0.9375 | 1.1035 | 0.9373 | 0.5039 | |
| HCC2185 | TNBC | Luminal | Sirolimus | MTOR | MTOR | 7464.069 | uM | 0.00147 | 0.00146 | -0.1430 | 0.0071 | 2.1945 | 0.7708 | 0.9675 | 0.6495 | |
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7462.085 | uM | 7.59760 | 7.15830 | -0.5274 | 0.0497 | 1.7575 | 0.3660 | 0.6025 | 0.3896 | |
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7463.084 | uM | 173.28310 | 360.46480 | -0.7734 | -1.0000 | 1.4999 | 0.3216 | 0.8080 | 0.7560 | |
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7464.084 | uM | 12.26940 | 52.37260 | -0.9938 | -1.0000 | 0.7570 | 0.5239 | 0.9749 | 0.8152 | |
| HCC2185 | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7463.067 | uM | 11.36450 | 14.15710 | -1.0000 | -1.0000 | 5.0000 | 0.4092 | 0.9907 | 0.6688 | |
| HCC2185 | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7464.067 | uM | 12.69390 | 15.8140 | -0.9991 | -0.9999 | 4.9987 | 0.3574 | 0.9942 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7462.067 | uM | 12.63210 | 15.73730 | -0.9999 | -0.9999 | 4.9982 | 0.3425 | 0.9972 | 0.4873 | |
| HCC2185 | TNBC | Luminal | TAPI-0 | TACE/Collagenase | 7462.096 | uM | 0.31064 | 0.30734 | -0.0269 | 0.0260 | 5.0000 | 0.3485 | 0.9689 | 0.3514 | ||
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 7848.002 | uM | 0.00463 | 0.00683 | -0.3379 | -0.3289 | 1.3012 | 0.8913 | 0.9640 | 0.5588 | |
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 9420.002 | uM | 0.00674 | 0.00772 | -0.4979 | -0.4884 | 5.0000 | 0.9765 | 0.9936 | 0.3242 | |
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 7849.002 | uM | 0.00876 | 0.00931 | -0.1459 | -0.1763 | 4.9996 | 0.7465 | 0.9941 | 0.5525 | |
| HCC2185 | TNBC | Luminal | Taxol | TUBB | TUBB | 9421.002 | uM | 0.00536 | 0.00657 | -0.3820 | -0.3593 | 2.6615 | 0.9054 | 0.9972 | 0.5336 | |
| HCC2185 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 12192.159 | uM | 1.54360 | 2.27160 | -0.4495 | -0.4850 | 1.7549 | 0.3806 | 0.9601 | 0.8215 | |
| HCC2185 | TNBC | Luminal | TCS 2312 | CHK1 | CHK | 10996.152 | uM | 1.22350 | 1.34990 | -0.3239 | -0.3172 | 5.0000 | 0.3252 | 0.9874 | 0.6343 | |
| HCC2185 | TNBC | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12192.135 | uM | inf | 13.29170 | 0.6965 | 0.7063 | 4.8079 | 0.0782 | 0.6951 | 0.6212 | |
| HCC2185 | TNBC | Luminal | Temsirolimus | MTOR | MTOR | 12192.144 | uM | 0.00382 | 0.03008 | -0.8304 | -0.5780 | 0.3722 | 0.9625 | 0.8793 | 0.5798 | |
| HCC2185 | TNBC | Luminal | Temsirolimus | MTOR | MTOR | 10996.144 | uM | 0.00375 | 0.18883 | -0.9997 | -1.0000 | 0.2804 | 0.9938 | 0.8849 | 0.5116 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 7849.043 | uM | 3.12740 | 4.96040 | -0.3722 | -0.3489 | 1.1476 | 0.3713 | 0.9195 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Topotecan | TOP1 | TOP | 7849.007 | uM | 0.03173 | 0.11605 | -0.6989 | -0.6087 | 0.6140 | 0.8354 | 0.9526 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Torkinib | 15306.211 | uM | 0.00017 | 0.00130 | -0.8220 | -0.8191 | 0.4777 | 1.4061 | 0.9962 | 0.4935 | |||
| HCC2185 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12192.16 | uM | 0.35927 | 0.12565 | 0.2935 | 0.3575 | 1.1951 | 0.2654 | 0.8281 | 0.7363 | |
| HCC2185 | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10996.15 | uM | 0.22479 | 0.19030 | 0.0203 | 0.1302 | 1.8105 | 0.3260 | 0.9140 | 0.5092 | |
| HCC2185 | TNBC | Luminal | TPCA-1 | IKK | NFKB | 7462.093 | uM | 5.50010 | 3.76590 | 0.3563 | 0.4248 | 5.0000 | 0.1224 | 0.9453 | 0.4426 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 7846.05 | uM | inf | inf | 0.2930 | 0.2930 | 0.0000 | 0.3262 | 0.2659 | 0.3833 |