Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 7845.05 | uM | inf | inf | 0.3425 | 0.3425 | 0.0000 | 0.3732 | 0.2723 | 0.4747 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 7848.05 | uM | inf | inf | 0.6452 | 0.6452 | 0.0000 | 0.1047 | 0.4160 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 9421.012 | uM | inf | 999.78290 | 0.5751 | -0.0451 | 0.1524 | 0.1932 | 0.5850 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 9420.012 | uM | 11.78230 | 14.67580 | -0.3118 | -0.9991 | 5.0000 | 0.2592 | 0.6528 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7462.065 | uM | 22.21550 | 27.67390 | -1.0000 | -0.9998 | 5.0000 | 0.8649 | 0.9889 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7463.065 | uM | 10.13520 | 13.1990 | -0.9994 | -0.9995 | 4.1581 | 0.9212 | 0.9975 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7464.065 | uM | 14.04140 | 20.51460 | -0.9938 | -0.9942 | 2.8876 | 0.8550 | 0.9984 | 0.7107 | |
| HCC2185 | TNBC | Luminal | Triciribine | AKT | AKT | 7462.074 | uM | 0.01558 | 0.06147 | -0.2375 | -0.4011 | 0.4292 | 0.6971 | 0.8823 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Triciribine | AKT | AKT | 7464.074 | uM | 0.03340 | 0.08635 | -0.4814 | -0.4205 | 0.6426 | 0.6376 | 0.9865 | 0.5504 | |
| HCC2185 | TNBC | Luminal | Triciribine | AKT | AKT | 7463.074 | uM | 0.00542 | 0.03653 | -0.6802 | -0.6973 | 0.4578 | 0.8845 | 0.9924 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 12192.143 | uM | 875.24030 | 1000.00000 | -0.9918 | -0.4735 | 5.0000 | 0.2690 | 0.8292 | 0.5995 | |
| HCC2185 | TNBC | Luminal | Valproic acid | HDAC | HDAC | 10996.143 | uM | 442.73320 | 1000.00000 | -1.0000 | -1.0000 | 1.3483 | 0.4840 | 0.9488 | 0.3034 | |
| HCC2185 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7848.042 | uM | 0.11629 | 2.91690 | -0.9984 | -1.0000 | 0.3410 | 0.5799 | 0.5882 | 0.4157 | |
| HCC2185 | TNBC | Luminal | Vinorelbine | TUBB | TUBB | 7845.018 | uM | 0.00524 | 0.00571 | -0.9983 | -0.2362 | 4.5293 | 0.7980 | 0.7029 | 0.4518 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7463.065 | uM | 39.44830 | 81.01570 | -0.9999 | -1.0000 | 1.5266 | 0.9356 | 0.9731 | 0.5226 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7462.065 | uM | 37.55690 | 65.95580 | -1.0000 | -1.0000 | 1.9509 | 0.9428 | 0.9838 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7464.065 | uM | 78.16440 | 137.31230 | -0.9959 | -1.0000 | 1.9498 | 0.7817 | 0.9980 | 0.7107 | |
| HCC2185 | TNBC | Luminal | XRP44X | ELK3 | MAPK | 12192.157 | uM | 1.02330 | 1.16680 | -0.4916 | -0.4633 | 5.0000 | 0.5722 | 0.9477 | 0.5774 | |
| HCC2185 | TNBC | Luminal | XRP44X | ELK3 | MAPK | 10996.151 | uM | 0.25028 | 0.30216 | -0.8380 | -0.7822 | 5.0000 | 0.8212 | 0.9846 | 0.4801 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 12192.16 | uM | 1.27190 | 0.63873 | 0.1767 | 0.2379 | 0.9378 | 0.3421 | 0.9088 | 0.7363 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 10996.15 | uM | 0.40751 | 0.34953 | 0.2637 | 0.2679 | 4.9990 | 0.2481 | 0.9682 | 0.5092 | |
| HCC3153 | TNBC | Basal A | (Z)-4-Hydroxytamoxifen | ESR1 | 7853.016 | uM | inf | 106.97610 | 0.8877 | 0.8536 | 2.6631 | 0.0083 | 0.6963 | 1.6178 | ||
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7853.04 | uM | 0.17003 | 0.19791 | -0.2733 | -0.1442 | 1.6685 | 0.5469 | 0.9879 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10577.143 | uM | 971.46680 | 1000.00000 | 0.0340 | -0.0227 | 1.5355 | 0.1782 | 0.9329 | 0.9750 | |
| HCC3153 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10937.143 | uM | 558.30230 | 999.99960 | -0.0412 | -0.3041 | 0.8151 | 0.2210 | 0.9770 | 1.3133 |