Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 12617.177 | uM | 0.09816 | 0.12091 | -0.9458 | -0.9166 | 4.9974 | 0.8416 | 0.9995 | 1.6822 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9028.075 | uM | 12.60320 | 24.29020 | -0.9556 | -0.9635 | 1.6368 | 0.5980 | 0.9966 | 0.6011 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10268.12 | uM | 0.41958 | 0.88930 | -1.0000 | -0.9927 | 1.4560 | 1.1119 | 0.9972 | 0.3272 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9453.011 | uM | 34.80390 | 42.89210 | -0.9585 | -0.9214 | 5.0000 | 0.5058 | 0.9973 | 0.7773 | |
| HCC38 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9469.011 | uM | 16.69430 | 29.46970 | -0.9027 | -0.8642 | 1.7662 | 0.5396 | 0.9975 | 1.1991 | |
| HCC38 | TNBC | Basal B | Celecoxib | COX2 | COX | 10578.136 | uM | inf | inf | 0.9640 | 0.9640 | 0.0000 | 0.0221 | 0.0000 | 1.5577 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9028.018 | uM | inf | inf | 0.8573 | 0.8573 | 0.0000 | 0.0500 | -0.0461 | 1.0242 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7854.018 | uM | inf | inf | 0.7802 | 0.7802 | 0.0000 | 0.1098 | 0.010 | 1.2298 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9453.125 | uM | inf | inf | 0.9729 | 0.9729 | 0.0000 | 0.0022 | 0.4453 | 1.2351 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9469.026 | uM | inf | inf | 0.8847 | 0.8847 | 0.0000 | 0.0250 | 0.5685 | 1.2092 | |
| HCC38 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 10268.122 | uM | 0.92849 | 0.80222 | 0.7620 | 0.2528 | 4.8199 | -0.0144 | 0.6866 | 0.6345 | |
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7854.018 | uM | 6.42560 | 102.48640 | -0.9293 | -1.0000 | 0.3967 | 0.6846 | 0.8816 | 1.2298 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9028.018 | uM | 4.79260 | 73.33330 | -0.9641 | -1.0000 | 0.4027 | 0.7219 | 0.9305 | 1.0242 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9469.026 | uM | 195.96770 | 357.18880 | -0.9676 | -1.0000 | 1.8301 | 0.5408 | 0.9367 | 1.2092 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9453.125 | uM | 22.15620 | 132.94570 | -0.9634 | -1.0000 | 0.6131 | 0.6089 | 0.9589 | 1.2351 | ||
| HCC38 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10268.122 | uM | 5.30470 | 5.72240 | -0.2302 | -0.2304 | 5.0000 | 0.1654 | 0.9920 | 0.6345 | ||
| HCC38 | TNBC | Basal B | Chk2 inhibitor II | CHK2 | CHK | 10578.14 | uM | inf | 1000.00000 | 0.8195 | 0.4391 | 0.3356 | 0.0492 | 0.6530 | 1.6718 | |
| HCC38 | TNBC | Basal B | Chloroquine | 12617.177 | uM | 16.65350 | 26.89110 | -0.1723 | -0.4930 | 1.4319 | 0.1596 | 0.9857 | 1.6822 | |||
| HCC38 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7854.017 | uM | 0.76109 | 2.0020 | -0.8559 | -0.8063 | 0.9929 | 0.7091 | 0.9809 | 1.3102 | |
| HCC38 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9453.017 | uM | 1.65980 | 3.82750 | -0.9253 | -0.9162 | 1.2461 | 0.6040 | 0.9959 | 1.2279 | |
| HCC38 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9469.131 | uM | 2.22290 | 4.52370 | -0.9577 | -0.9342 | 1.4831 | 0.6079 | 0.9979 | 1.0627 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 10268.007 | uM | 0.27694 | 0.56967 | -0.9094 | -0.8638 | 1.3912 | 0.6759 | 0.9972 | 1.3306 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9469.121 | uM | 0.73989 | 1.38720 | -0.8343 | -0.8389 | 1.5671 | 0.5887 | 0.9989 | 1.1298 | |
| HCC38 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9453.121 | uM | 0.6930 | 1.34280 | -0.8529 | -0.8363 | 1.4861 | 0.5887 | 0.9993 | 1.2860 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 11850.155 | uM | inf | inf | 0.5069 | 0.5069 | 0.0000 | 0.3134 | 0.5180 | 2.1810 |