Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HCC3153
TNBC
Basal A
 5-FU
TYMS
TYMS
7853.017
uM
424.27250
576.46540
 -0.0594 -0.1338 0.7734 0.3182
0.9997
 1.7375
HCC3153
TNBC
Basal A
 AG1024
IGF1R
RTK
7465.066
uM
62.07240
384.31460
 0.6227 -0.9619 0.5885 0.0629
0.7553
 1.2627
HCC3153
TNBC
Basal A
 AG1024
IGF1R
RTK
7467.066
uM
8.65110
7.7280
 0.2160 0.2155 4.9965 0.0900
0.9709
 1.1956
HCC3153
TNBC
Basal A
 AG1024
IGF1R
RTK
7466.066
uM
6.52780
6.35240
 0.0639 0.0636 5.0000 0.0881
0.9851
 0.9420
HCC3153
TNBC
Basal A
 AG1478
EGFR
ErbB
7853.016
uM
inf
inf
 0.9101 0.9101 0.0000 0.0481
0.4996
 1.6178
HCC3153
TNBC
Basal A
 AS-252424
PI3K
PI3K
10577.141
uM
inf
inf
 0.6513 0.6513 0.0000 0.1435
0.2989
 0.9203
HCC3153
TNBC
Basal A
 AS-252424
PI3K
PI3K
10937.153
uM
inf
1.51340
 0.7217 0.7408 4.9986 0.0684
0.8932
 1.5187
HCC3153
TNBC
Basal A
 Baicalein
Lipoxygenase
Metabolism
10577.072
uM
26.93890
27.35440
 -0.0395 -0.0398 5.0000 0.1713
0.9884
 0.9803
HCC3153
TNBC
Basal A
 Baicalein
Lipoxygenase
Metabolism
7465.072
uM
21.80280
19.91310
 0.1274 0.0481 1.1160 0.1628
0.9887
 1.3502
HCC3153
TNBC
Basal A
 Baicalein
Lipoxygenase
Metabolism
10937.072
uM
20.61690
20.12190
 0.0352 0.0254 2.1423 0.1301
0.9894
 1.3076
HCC3153
TNBC
Basal A
 Baicalein
Lipoxygenase
Metabolism
7466.072
uM
14.67170
18.50420
 -0.3467 -0.3546 2.3095 0.2207
0.9952
 0.7283
HCC3153
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
7466.074
uM
0.05672
0.07706
 -0.9831 -0.9844 3.5500 1.1766
0.9989
 0.9724
HCC3153
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
7466.074
uM
0.05672
0.07706
 -0.9831 -0.9844 3.5500 1.1766
0.9989
 0.9724
HCC3153
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
14906.203
uM
0.00480
0.00655
 -0.9875 -0.9877 3.5203 1.4194
0.9990
 0.7818
HCC3153
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
14906.203
uM
0.00480
0.00655
 -0.9875 -0.9877 3.5203 1.4194
0.9990
 0.7818
HCC3153
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
7467.074
uM
0.07074
0.11307
 -0.9666 -0.9602 2.2849 1.1087
0.9999
 1.2457
HCC3153
TNBC
Basal A
 Bortezomib
Proteasome
Proteasome
7467.074
uM
0.07074
0.11307
 -0.9666 -0.9602 2.2849 1.1087
0.9999
 1.2457
HCC3153
TNBC
Basal A
 Bosutinib
Src
nRTK
10577.145
uM
8.8860
5.78930
 0.2386 0.2541 1.6560 0.1768
0.9598
 0.9676
HCC3153
TNBC
Basal A
 Bosutinib
Src
nRTK
10937.145
uM
3.56130
6.19760
 -0.9728 -0.9773 1.9554 0.4434
0.9949
 1.2098
HCC3153
TNBC
Basal A
 Carboplatin
DNA cross-linker
DNA cross-linker
10056.021
uM
46.19960
55.15930
 -0.8595 -0.7128 4.9990 0.4907
0.9762
 0.8839
HCC3153
TNBC
Basal A
 Carboplatin
DNA cross-linker
DNA cross-linker
7853.011
uM
46.46770
52.49410
 -0.5641 -0.4200 5.0000 0.3745
0.9845
 1.6331
HCC3153
TNBC
Basal A
 Celecoxib
COX2
COX
10577.136
uM
inf
inf
 0.8434 0.8434 0.0000 0.1277
-0.1585
 0.9962
HCC3153
TNBC
Basal A
 Cetuximab
EGFR
ErbB
7853.042
uM
inf
0.03832
 0.7166 0.7810 5.0000 0.0679
0.7871
 1.7624
HCC3153
TNBC
Basal A
 CGC-11047
Polyamine analogue
10056.034
uM
4.94730
53.82750
 -0.9867 -1.0000 0.4603 0.7287
0.9511
 0.8648
HCC3153
TNBC
Basal A
 Chk2 inhibitor II
CHK2
CHK
10577.14
uM
inf
5.07960
 0.8649 0.8687 4.9994 0.0319
0.7267
 0.9722