Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 10996.143 | uM | 124.03170 | 741.86030 | -0.5992 | -1.0000 | 0.6142 | 0.4500 | 0.8811 | 0.3034 | |
| HCC2185 | TNBC | Luminal | 5-DFUR | TYMS | TYMS | 12192.143 | uM | 875.95260 | 1000.00000 | -0.0499 | -0.1056 | 1.4465 | 0.1455 | 0.9340 | 0.5995 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7846.017 | uM | 414.55880 | 708.82680 | -0.7862 | -0.6921 | 1.6199 | 0.3915 | 0.9887 | 0.3403 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7849.017 | uM | 532.52940 | 619.620 | -0.6891 | -0.5663 | 5.0000 | 0.3976 | 0.990 | 0.3471 | |
| HCC2185 | TNBC | Luminal | 5-FU | TYMS | TYMS | 7848.017 | uM | 418.4950 | 571.66450 | -0.7572 | -0.6622 | 2.7044 | 0.4233 | 0.9935 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Afatinib | EGFR/HER2 | ErbB | 12192.158 | uM | 1.23320 | 3.12870 | -0.9974 | -1.0000 | 1.1800 | 0.5426 | 0.9697 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AG1024 | IGF1R | RTK | 7462.066 | uM | 20.00240 | 272.660 | 0.4013 | -1.0000 | 0.4205 | 0.1535 | 0.8076 | 0.5644 | |
| HCC2185 | TNBC | Luminal | AG1024 | IGF1R | RTK | 7464.066 | uM | 11.25690 | 7.17540 | 0.4476 | 0.4474 | 4.9995 | 0.0281 | 0.9566 | 0.6384 | |
| HCC2185 | TNBC | Luminal | AG1024 | IGF1R | RTK | 7463.066 | uM | 4.09790 | 3.89070 | 0.0659 | 0.0411 | 1.6536 | 0.1702 | 0.9585 | 0.5542 | |
| HCC2185 | TNBC | Luminal | AG1478 | EGFR | ErbB | 7845.016 | uM | 2.98440 | 43.37830 | -0.5324 | -1.0000 | 0.4105 | 0.4106 | 0.7762 | 0.4392 | |
| HCC2185 | TNBC | Luminal | AG1478 | EGFR | ErbB | 7846.016 | uM | 3.19930 | 11.74650 | -0.5650 | -0.7419 | 0.6995 | 0.4549 | 0.7873 | 0.3279 | |
| HCC2185 | TNBC | Luminal | AG1478 | EGFR | ErbB | 7848.016 | uM | inf | 1.18170 | 0.7455 | 0.7732 | 4.9854 | 0.0964 | 0.8337 | 0.4818 | |
| HCC2185 | TNBC | Luminal | AG1478 | EGFR | ErbB | 7849.016 | uM | 54.69230 | 999.81890 | 0.2939 | -0.8715 | 0.3473 | 0.1777 | 0.8548 | 0.3419 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 12192.158 | uM | inf | 1.25610 | 0.7404 | 0.8011 | 4.9939 | 0.0559 | 0.7125 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 10996.153 | uM | 1.80440 | 3.40920 | -0.4709 | -0.5709 | 1.1971 | 0.3091 | 0.9826 | 0.3186 | |
| HCC2185 | TNBC | Luminal | Baicalein | Lipoxygenase | Metabolism | 10996.072 | uM | 59.44960 | 221.38230 | 0.0876 | -1.0000 | 0.8356 | 0.1808 | 0.8068 | 0.6093 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7462.074 | uM | 0.00678 | 0.02926 | -0.9723 | -0.9726 | 0.7385 | 1.3116 | 0.9790 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7462.074 | uM | 0.00678 | 0.02926 | -0.9723 | -0.9726 | 0.7385 | 1.3116 | 0.9790 | 0.6126 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7463.074 | uM | 0.01945 | 0.03339 | -0.9295 | -0.8410 | 1.8261 | 1.2121 | 0.9953 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7463.074 | uM | 0.01945 | 0.03339 | -0.9295 | -0.8410 | 1.8261 | 1.2121 | 0.9953 | 0.4574 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7464.074 | uM | 0.03896 | 0.04762 | -0.9307 | -0.8644 | 4.9998 | 1.1777 | 0.9954 | 0.5504 | |
| HCC2185 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7464.074 | uM | 0.03896 | 0.04762 | -0.9307 | -0.8644 | 4.9998 | 1.1777 | 0.9954 | 0.5504 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 10996.145 | uM | 4.61840 | 10.55780 | -0.4192 | -0.5885 | 0.9409 | 0.3387 | 0.9337 | 0.5765 | |
| HCC2185 | TNBC | Luminal | Bosutinib | Src | nRTK | 12192.145 | uM | 4.28340 | 4.5580 | -0.1903 | -0.1819 | 4.9939 | 0.2408 | 0.9944 | 0.4175 | |
| HCC2185 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 13.02370 | 26.1650 | -1.0000 | -1.0000 | 1.5747 | 0.5987 | 0.9904 | 0.3726 |