Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7849.011 | uM | 27.7340 | 68.96840 | -0.9984 | -1.0000 | 1.2060 | 0.4773 | 0.9931 | 0.5467 | |
| HCC2185 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7848.011 | uM | 22.99330 | 53.01150 | -1.0000 | -0.9999 | 1.3151 | 0.4841 | 0.9976 | 0.3405 | |
| HCC2185 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 7845.018 | uM | inf | inf | 0.3134 | 0.3134 | 0.0000 | 0.1983 | 0.0987 | 0.4518 | |
| HCC2185 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 7848.042 | uM | inf | inf | 0.8862 | 0.8862 | 0.0000 | -0.0398 | 0.1615 | 0.4157 | |
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 9421.034 | uM | 8.90130 | 310.67280 | -0.9800 | -1.0000 | 0.3093 | 0.5866 | 0.7305 | 0.6220 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 10263.034 | uM | 0.59694 | 64.10150 | -0.9993 | -1.0000 | 0.2349 | 0.7794 | 0.7511 | 0.3750 | ||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 7845.018 | uM | 1.29170 | 53.1530 | -0.9941 | -1.0000 | 0.2956 | 0.7642 | 0.7830 | 0.4518 | ||
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7846.017 | uM | 2.36570 | 3.56410 | -1.0000 | -0.9990 | 2.6791 | 0.6583 | 0.9925 | 0.3403 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9421.021 | uM | 1.64960 | 2.88290 | -1.0000 | -0.9906 | 1.9565 | 0.6753 | 0.9969 | 0.3726 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7848.017 | uM | 2.61350 | 5.15150 | -1.0000 | -1.0000 | 1.6190 | 0.5752 | 0.9974 | 0.3225 | |
| HCC2185 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7849.017 | uM | 2.68670 | 5.07190 | -1.0000 | -1.0000 | 1.7290 | 0.5906 | 0.9982 | 0.3471 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 7849.043 | uM | inf | 21.35240 | 0.6838 | 0.6829 | 4.7284 | 0.0074 | 0.8301 | 0.3502 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 7849.007 | uM | 8.88080 | 36.61320 | -0.0418 | -0.7034 | 0.6201 | 0.1928 | 0.9630 | 0.4353 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 10263.034 | uM | 1.76130 | 2.7730 | -0.5448 | -0.5665 | 1.6689 | 0.4269 | 0.9813 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 9421.034 | uM | 4.04040 | 4.15410 | -0.0256 | -0.0184 | 1.2999 | 0.2027 | 0.9875 | 0.6220 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 12192.155 | uM | inf | inf | 0.3402 | 0.3402 | 0.0000 | 0.4963 | 0.5727 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 10996.155 | uM | 0.35269 | 0.32503 | 0.1344 | 0.1676 | 5.0000 | 0.3368 | 0.6218 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7848.002 | uM | 0.00176 | 0.00217 | -0.0325 | -0.1015 | 0.8880 | 0.7481 | 0.9274 | 0.5588 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7849.002 | uM | 0.00354 | 0.00355 | 0.0715 | -0.0010 | 1.5701 | 0.6158 | 0.9724 | 0.5525 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9421.002 | uM | 0.00299 | 0.00321 | -0.1006 | -0.2178 | 5.0000 | 0.7705 | 0.9793 | 0.5336 | |
| HCC2185 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9420.002 | uM | 0.00221 | 0.00307 | -0.3921 | -0.4272 | 1.8972 | 0.9033 | 0.9915 | 0.3242 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 7849.043 | uM | 2.69180 | 6.57250 | -0.8857 | -1.0000 | 1.2307 | 0.4735 | 0.9595 | 0.3502 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 7849.007 | uM | 0.16609 | 0.27015 | -0.5541 | -0.5340 | 1.4937 | 0.7316 | 0.9790 | 0.4353 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 10263.034 | uM | 0.02525 | 0.11148 | -1.0000 | -1.0000 | 0.7398 | 1.0785 | 0.9792 | 0.3750 | |
| HCC2185 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 9421.034 | uM | 0.06107 | 0.24961 | -0.9990 | -0.9959 | 0.7784 | 0.9110 | 0.9962 | 0.6220 |