Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 10937.154 | uM | inf | inf | 0.8788 | 0.8788 | 0.0000 | 0.0562 | -0.0558 | 1.5291 | |
| HCC3153 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 10577.142 | uM | inf | inf | 0.8245 | 0.8245 | 0.0000 | 0.1675 | 0.0000 | 1.0584 | |
| HCC3153 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7853.016 | uM | 48.13030 | 120.19590 | 0.6105 | -0.6666 | 0.9258 | 0.0486 | 0.9494 | 1.6178 | |
| HCC3153 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 10056.012 | uM | 0.07489 | 0.10209 | -0.4085 | -0.3544 | 1.7290 | 0.7231 | 0.9966 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7853.04 | uM | 0.05048 | 0.05881 | -0.1990 | -0.1606 | 1.8250 | 0.6646 | 0.9985 | 1.6581 | |
| HCC3153 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7853.011 | uM | inf | 0.01974 | 0.5123 | 0.5486 | 3.3194 | 0.3149 | 0.9622 | 1.6331 | |
| HCC3153 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 10577.138 | uM | inf | inf | 0.8823 | 0.8823 | 0.0000 | 0.0414 | 0.5066 | 1.0408 | ||
| HCC3153 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 10937.15 | uM | inf | 7.30490 | 0.6869 | 0.6867 | 4.9982 | 0.0328 | 0.9034 | 1.3769 | ||
| HCC3153 | TNBC | Basal A | GM6001 | MMP | MMP | 7466.096 | uM | inf | inf | 0.8967 | 0.8967 | 0.0000 | 0.0827 | -0.1319 | 0.9269 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7853.001 | uM | 8.20720 | 30.58260 | -0.0642 | -1.0000 | 0.8352 | 0.1798 | 0.9652 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 10056.001 | uM | 12.78590 | 52.63390 | 0.1678 | -1.0000 | 0.7764 | 0.1357 | 0.9744 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7465.092 | uM | 1.13430 | 0.43772 | 0.3351 | 0.4396 | 2.2193 | 0.2699 | 0.7548 | 1.2055 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7466.092 | uM | 11.54640 | 29.94250 | -0.4966 | -1.0000 | 1.1529 | 0.2125 | 0.9541 | 0.9158 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7465.098 | uM | 2.70770 | 19.58910 | -0.4338 | -1.0000 | 0.5552 | 0.3324 | 0.9696 | 1.2188 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7467.091 | uM | 5.73110 | 6.93540 | -0.8283 | -0.7976 | 5.0000 | 0.4314 | 0.9856 | 1.2996 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7466.098 | uM | 2.68260 | 5.79730 | -0.0812 | -0.3226 | 0.6461 | 0.2933 | 0.9909 | 0.8226 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7467.098 | uM | 4.84670 | 5.37130 | -0.1281 | -0.1320 | 2.2795 | 0.2406 | 0.9914 | 1.4178 | |
| HCC3153 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7467.071 | uM | 6.45080 | 10.39230 | -0.8670 | -0.8808 | 2.1302 | 0.3755 | 0.9970 | 1.3411 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 10056.001 | uM | 0.01507 | 0.01546 | -0.4012 | -0.0660 | 4.9405 | 0.5985 | 0.9322 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK461364 | PLK1 | PLK | 7853.001 | uM | 0.01639 | 0.01599 | -0.0665 | 0.0572 | 5.0000 | 0.5432 | 0.9801 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 10056.001 | uM | 0.06152 | 0.06779 | -0.1880 | -0.1777 | 3.1365 | 0.5741 | 0.9955 | 0.9052 | |
| HCC3153 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 7853.001 | uM | 0.07438 | 0.07771 | -0.1199 | -0.1024 | 4.2537 | 0.5120 | 0.9978 | 1.5775 | |
| HCC3153 | TNBC | Basal A | GW-5074 | CRAF | MAPK | 7466.088 | uM | inf | inf | 0.7503 | 0.7503 | 0.0000 | 0.0866 | 0.2768 | 0.9180 | |
| HCC3153 | TNBC | Basal A | GW843682X | PLK | PLK | 10577.139 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0263 | -0.5932 | 0.9234 | |
| HCC3153 | TNBC | Basal A | Ibandronate | FDPS | 10577.143 | uM | 89.28070 | 97.7030 | -0.0588 | -0.0789 | 1.6262 | 0.2539 | 0.9810 | 0.9750 |