Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Omipalisib | PI3K | PI3K | 7449.086 | uM | 0.02058 | 0.02159 | -0.0287 | -0.0260 | 1.0582 | 0.5879 | 0.9970 | 2.0500 | |
| HCC1569 | HER2amp | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7825.011 | uM | 4.73660 | 11.85220 | -0.1553 | -0.2893 | 0.4977 | 0.4115 | 0.9758 | 1.9334 | |
| HCC1569 | HER2amp | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9347.011 | uM | 8.21820 | 18.530 | -0.2089 | -0.3213 | 0.6104 | 0.3801 | 0.9820 | 1.6648 | |
| HCC1569 | HER2amp | Basal A | Oxamflatin | HDAC | HDAC | 10872.147 | uM | 0.81346 | 2.15590 | -0.7963 | -0.8993 | 1.0558 | 0.5386 | 0.9907 | 1.6255 | |
| HCC1569 | HER2amp | Basal A | Oxamflatin | HDAC | HDAC | 12523.147 | uM | 2.49980 | 3.57780 | -0.8879 | -0.9031 | 2.8779 | 0.4262 | 0.9979 | 0.9214 | |
| HCC1569 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 12523.152 | uM | inf | inf | 1.0310 | 1.0310 | 0.0000 | -0.0401 | -9.8795 | 0.8423 | |
| HCC1569 | HER2amp | Basal A | PD 98059 | MEK | MAPK | 10872.152 | uM | inf | inf | 0.7580 | 0.7580 | 0.0000 | 0.1442 | 0.1498 | 1.5916 | |
| HCC1569 | HER2amp | Basal A | PD173074 | FGFR1/3 | RTK | 10442.093 | uM | 6.56210 | 11.29660 | -0.8026 | -1.0000 | 2.0225 | 0.2116 | 0.9951 | 1.6861 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 10872.155 | uM | inf | inf | 0.9297 | 0.9297 | 0.0000 | 0.0301 | 0.0000 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 10872.155 | uM | inf | inf | 0.9297 | 0.9297 | 0.0000 | 0.0301 | 0.0000 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 12523.155 | uM | inf | inf | 0.9460 | 0.9460 | 0.0000 | 0.0104 | 0.1224 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | PD184352 | MEK | MAPK | 12523.155 | uM | inf | inf | 0.9460 | 0.9460 | 0.0000 | 0.0104 | 0.1224 | 1.0583 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7449.095 | uM | inf | inf | 0.9175 | 0.9175 | 0.0000 | 0.0613 | 0.3814 | 2.0118 | |
| HCC1569 | HER2amp | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7448.095 | uM | inf | 203.57140 | 0.3634 | 0.5672 | 4.9997 | 0.1044 | 0.7575 | 2.9105 | |
| HCC1569 | HER2amp | Basal A | Pertuzumab | 7447.102 | mg/ml | inf | 124.99960 | 0.8861 | 0.6968 | 0.1346 | 0.0581 | 0.6369 | 1.6467 | |||
| HCC1569 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7449.065 | uM | inf | inf | 0.9600 | 0.9600 | 0.0000 | 0.0227 | 0.1556 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | PS-1145 | IKK | NFKB | 7448.065 | uM | inf | 1000.00000 | 0.9134 | 0.9101 | 5.0000 | -0.0012 | 0.7365 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7449.067 | uM | inf | inf | 0.8522 | 0.8522 | 0.0000 | 0.0013 | 0.3467 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7448.067 | uM | inf | 8.38460 | 0.5825 | 0.6294 | 5.0000 | 0.0866 | 0.9666 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 7447.067 | uM | 18.52570 | 22.07880 | -0.3005 | -0.3059 | 2.7205 | 0.2178 | 0.9963 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ribavirin | 15388.211 | uM | inf | inf | 0.9655 | 0.9655 | 0.0000 | 0.0072 | -0.0182 | 1.5247 | |||
| HCC1569 | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 12523.168 | uM | inf | inf | 1.0409 | 1.0409 | 0.0000 | -0.0083 | -0.040 | 0.9035 | |
| HCC1569 | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 10872.144 | uM | inf | 25.11680 | 0.8015 | 0.8012 | 4.9407 | -0.0061 | 0.8436 | 1.5447 | |
| HCC1569 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 10872.155 | uM | inf | inf | 0.9648 | 0.9648 | 0.0000 | 0.0039 | 0.1215 | 1.5288 | |
| HCC1569 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 12523.155 | uM | inf | inf | 0.8410 | 0.8410 | 0.0000 | 0.0432 | 0.2612 | 1.0583 |