Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 10262.021 | uM | 37.6510 | 50.43530 | -0.9519 | -0.8597 | 3.4222 | 0.4481 | 0.9944 | 0.6806 | |
| HCC1937 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7834.075 | uM | 40.66670 | 90.07460 | -0.6087 | -0.6806 | 1.0804 | 0.3561 | 0.9982 | 2.0182 | |
| HCC1937 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7833.042 | uM | inf | inf | 0.8856 | 0.8856 | 0.0000 | 0.0972 | 0.0274 | 1.0332 | |
| HCC1937 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7834.018 | uM | inf | inf | 0.8939 | 0.8939 | 0.0000 | 0.0410 | 0.4149 | 1.8951 | |
| HCC1937 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7832.042 | uM | 0.57736 | 1.87360 | 0.4323 | -1.0000 | 0.9333 | 0.0778 | 0.8653 | 1.2810 | |
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7834.018 | uM | 14.58470 | 764.7230 | -0.4460 | -1.0000 | 0.2775 | 0.5236 | 0.9101 | 1.8951 | ||
| HCC1937 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 10262.034 | uM | 2.42290 | 59.75010 | -0.9033 | -1.0000 | 0.3428 | 0.7559 | 0.9172 | 0.6634 | ||
| HCC1937 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7833.017 | uM | inf | inf | 0.2921 | 0.2921 | 0.0000 | 0.1679 | 0.5260 | 1.2975 | |
| HCC1937 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 10262.021 | uM | 5.06270 | 8.92370 | -0.9411 | -0.8884 | 1.8018 | 0.4842 | 0.9909 | 0.6806 | |
| HCC1937 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7834.13 | uM | 3.49250 | 6.46710 | -0.6646 | -0.6160 | 1.3032 | 0.4666 | 0.9939 | 1.9535 | |
| HCC1937 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7832.017 | uM | 3.09750 | 4.99740 | -0.8487 | -0.8107 | 2.0147 | 0.5488 | 0.9987 | 1.3404 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 10262.034 | uM | 6.33790 | 16.09640 | -0.8558 | -1.0000 | 1.1787 | 0.2986 | 0.9773 | 0.6634 | |
| HCC1937 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7833.007 | uM | 10.7270 | 30.9040 | -0.0519 | -0.5994 | 0.7447 | 0.1769 | 0.9924 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 11849.155 | uM | inf | 0.35385 | 0.5815 | 0.5264 | 5.0000 | 0.1889 | 0.6353 | 1.4975 | |
| HCC1937 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13115.176 | uM | inf | 0.22160 | 0.8209 | 0.8738 | 5.0000 | 0.0131 | 0.6538 | 0.8197 | |
| HCC1937 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 13115.174 | uM | 0.08360 | 0.08711 | -0.7883 | -0.1139 | 4.9999 | 0.5498 | 0.7045 | 0.8122 | |
| HCC1937 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 10262.002 | uM | 0.00534 | 0.00521 | 0.0885 | 0.0565 | 5.0000 | 0.5451 | 0.9835 | 0.6356 | |
| HCC1937 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7833.007 | uM | inf | inf | -0.0795 | -0.0795 | 0.0000 | 0.4727 | 0.4296 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 10262.034 | uM | 0.29470 | 0.74270 | -0.8572 | -0.8195 | 1.0498 | 0.6968 | 0.9915 | 0.6634 | |
| HCC1937 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7833.017 | uM | inf | inf | 0.3101 | 0.3101 | 0.0000 | 0.2828 | 0.5559 | 1.2975 | |
| HCC1937 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7832.017 | uM | 0.20024 | 0.46689 | -0.9960 | -0.7800 | 1.1103 | 0.8016 | 0.9816 | 1.3404 | |
| HCC1937 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7453.091 | uM | 61.32890 | 999.85560 | 0.4611 | -0.7525 | 0.3290 | 0.1505 | 0.9376 | 1.5914 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 7452.074 | uM | 4.55290 | 7.95810 | -0.3493 | -0.3867 | 1.0260 | 0.3818 | 0.9932 | 1.5162 | |
| HCC1937 | TNBC | Basal A | Etoposide | TOP2 | TOP | 7453.074 | uM | 5.28690 | 8.98490 | -0.3367 | -0.3700 | 1.0444 | 0.3794 | 0.9958 | 1.5871 | |
| HCC1937 | TNBC | Basal A | Everolimus | MTOR | MTOR | 11849.156 | uM | 0.71938 | 10.34880 | -0.8391 | -1.0000 | 0.4120 | 0.4321 | 0.7829 | 1.0836 |