Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9254.001 | uM | 0.00450 | 0.00522 | -1.0000 | -0.5435 | 5.0000 | 1.0717 | 0.8911 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7816.001 | uM | 0.00151 | 0.00173 | -0.9805 | -0.4672 | 4.9998 | 1.1061 | 0.9094 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 7813.001 | uM | 0.01050 | 0.01379 | -0.9995 | -0.5491 | 2.7174 | 0.8875 | 0.9467 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9258.001 | uM | 0.00597 | 0.01523 | -1.0000 | -0.7752 | 1.0006 | 1.0407 | 0.9835 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7813.001 | uM | 0.03847 | 0.05595 | -0.7366 | -0.5681 | 2.0268 | 0.8249 | 0.8970 | 0.7338 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 7816.001 | uM | 0.03858 | 0.04680 | -0.8697 | -0.4666 | 3.4143 | 0.7175 | 0.9506 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9258.001 | uM | 0.02841 | 0.04065 | -0.7209 | -0.6324 | 2.2816 | 0.8705 | 0.9726 | 0.7137 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9254.001 | uM | 0.02742 | 0.03281 | -0.9898 | -0.7258 | 5.0000 | 0.9333 | 0.9796 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 7436.088 | uM | inf | inf | 0.7759 | 0.7759 | 0.0000 | 0.0514 | 0.5263 | 1.1615 | |
| HCC1395 | TNBC | Basal B | Ibandronate | FDPS | 12084.143 | uM | 16.05710 | 31.64790 | -0.0190 | -0.1938 | 0.4827 | 0.4042 | 0.9268 | 1.3499 | ||
| HCC1395 | TNBC | Basal B | Ibandronate | FDPS | 12000.143 | uM | 7.09140 | 49.09560 | -0.3307 | -0.6774 | 0.4426 | 0.5216 | 0.9701 | 0.8939 | ||
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 12084.157 | uM | inf | 8.3170 | 0.6700 | 0.6698 | 4.1481 | 0.0506 | 0.8459 | 1.3475 | |
| HCC1395 | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 12000.157 | uM | 5.80140 | 126.59960 | 0.0919 | -1.0000 | 0.3564 | 0.2465 | 0.9180 | 0.7671 | |
| HCC1395 | TNBC | Basal B | IKK16 | IKK | NFKB | 7436.093 | uM | 1.71150 | 3.09860 | -0.9583 | -1.0000 | 1.8507 | 0.4762 | 0.9952 | 1.2596 | |
| HCC1395 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7435.091 | uM | 10.95810 | 20.9510 | -1.0000 | -1.0000 | 1.6951 | 0.5709 | 0.9856 | 0.5716 | |
| HCC1395 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7436.091 | uM | 23.53280 | 29.92030 | -0.9599 | -0.9588 | 4.4587 | 0.4143 | 0.9978 | 1.2489 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7436.067 | uM | 0.03673 | 0.04246 | -0.9711 | -0.5301 | 4.9867 | 0.7857 | 0.9340 | 1.2834 | |
| HCC1395 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7435.067 | uM | 0.01113 | 0.01926 | -0.9999 | -0.7978 | 1.7403 | 1.0215 | 0.9797 | 0.7691 | |
| HCC1395 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7436.095 | uM | 0.01696 | 0.02202 | -0.9468 | -0.2878 | 1.7422 | 0.7040 | 0.8234 | 1.3597 | |
| HCC1395 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7435.095 | uM | 0.00671 | 0.00955 | -0.8303 | -0.4035 | 1.6795 | 0.8925 | 0.8773 | 0.8762 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 12084.144 | uM | 1.70250 | 1.60430 | 0.0230 | 0.1284 | 5.0000 | 0.3083 | 0.8559 | 1.4700 | |
| HCC1395 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 12000.168 | uM | 1.89760 | 2.22170 | -0.6361 | -0.6000 | 5.0000 | 0.6038 | 0.9752 | 0.7873 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 12000.166 | uM | 26.11470 | 32.14790 | -0.0409 | -0.9135 | 5.0000 | 0.1196 | 0.9129 | 0.7468 | |
| HCC1395 | TNBC | Basal B | L-779450 | BRAF | MAPK | 12084.161 | uM | 14.78670 | 26.51780 | -0.5384 | -1.0000 | 1.8809 | 0.1565 | 0.9896 | 1.4492 | |
| HCC1395 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7435.098 | uM | inf | inf | 0.8541 | 0.8541 | 0.0000 | 0.1309 | 0.1162 | 0.7702 |