Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Etoposide | TOP2 | TOP | 7432.074 | uM | 0.30344 | 1.52030 | -0.9717 | -1.0000 | 0.6817 | 0.8363 | 0.9423 | 0.8598 | |
| HCC1187 | TNBC | Basal A | Etoposide | TOP2 | TOP | 7431.074 | uM | 1.17190 | 3.15340 | -0.8942 | -0.8790 | 1.0249 | 0.6849 | 0.9885 | 1.4349 | |
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7432.084 | uM | 0.01028 | 0.01685 | -0.9998 | -0.9951 | 2.2156 | 1.1594 | 0.9992 | 0.8538 | |
| HCC1187 | TNBC | Basal A | Fascaplysin | CDK4 | CDK | 7433.084 | uM | 0.01972 | 0.03502 | -0.9962 | -0.9950 | 1.9076 | 1.0637 | 0.9998 | 1.0291 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 10518.137 | uM | 25.61280 | 147.06970 | 0.4349 | -1.0000 | 0.6286 | 0.1216 | 0.7415 | 1.2405 | |
| HCC1187 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 10753.149 | uM | 57.42480 | 297.26360 | 0.6138 | -1.0000 | 0.6682 | 0.0749 | 0.8238 | 1.4167 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 10753.154 | uM | inf | inf | 1.0162 | 1.0162 | 0.0000 | -0.0376 | -5.9291 | 1.4444 | |
| HCC1187 | TNBC | Basal A | FTase Inhibitor I | Ftase | MAPK | 10518.142 | uM | inf | inf | 0.9343 | 0.9343 | 0.0000 | 0.0364 | -0.0557 | 1.2869 | |
| HCC1187 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7812.016 | uM | 29.60580 | 38.26770 | 0.4096 | -0.4031 | 2.3039 | 0.0530 | 0.9455 | 1.0628 | |
| HCC1187 | TNBC | Basal A | Gefitinib | EGFR | ErbB | 7811.044 | uM | 24.92130 | 30.93870 | -0.1669 | -0.9744 | 5.0000 | 0.0514 | 0.9684 | 0.3073 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 9244.012 | uM | 0.01697 | 0.02114 | -0.3844 | -0.5319 | 3.3017 | 1.0194 | 0.940 | 0.4292 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7812.04 | uM | 0.01525 | 0.01354 | 0.2627 | 0.2243 | 5.0000 | 0.5217 | 0.9633 | 1.0573 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7811.04 | uM | 0.05228 | 0.06299 | -0.8492 | -0.7691 | 5.0000 | 0.9963 | 0.9944 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7812.011 | uM | 518.62050 | 0.52096 | 0.4679 | 0.4620 | 0.3733 | 0.2402 | 0.7728 | 1.0620 | |
| HCC1187 | TNBC | Basal A | Gemcitabine | DNA replication | DNA replication | 7811.011 | uM | 0.30922 | 0.45060 | -0.2941 | -0.2908 | 1.2176 | 0.6183 | 0.9383 | 0.4400 | |
| HCC1187 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 10753.15 | uM | 0.72667 | 1.03870 | -0.4079 | -0.3348 | 1.4348 | 0.3876 | 0.9719 | 1.4129 | ||
| HCC1187 | TNBC | Basal A | Glycyl-H-1152 | ROCK2 | 10518.138 | uM | 0.43471 | 0.58591 | -0.2990 | -0.2511 | 1.3632 | 0.3973 | 0.9939 | 1.3413 | ||
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7812.001 | uM | 0.01221 | 0.0150 | -0.8531 | -0.6455 | 4.0237 | 0.9376 | 0.9857 | 1.0060 | |
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7811.001 | uM | 0.01148 | 0.01402 | -0.9576 | -0.8571 | 5.0000 | 1.0993 | 0.9874 | 0.4464 | |
| HCC1187 | TNBC | Basal A | GSK1070916 | AURK | AURK | 9244.001 | uM | 0.00874 | 0.01067 | -0.8996 | -0.8591 | 5.0000 | 1.1518 | 0.9961 | 0.5421 | |
| HCC1187 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7432.098 | uM | 2.47890 | 2.71390 | -0.9806 | -0.2864 | 5.0000 | 0.4040 | 0.6929 | 1.0423 | |
| HCC1187 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7433.071 | uM | 103.91080 | 175.90610 | 0.4637 | -0.1278 | 0.4324 | 0.1139 | 0.9308 | 1.0393 | |
| HCC1187 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7431.092 | uM | 2.7610 | 4.60660 | -0.9070 | -0.9485 | 2.0780 | 0.4809 | 0.9690 | 1.5006 | |
| HCC1187 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7433.098 | uM | 3.16530 | 5.66550 | -0.9600 | -0.9903 | 1.8761 | 0.4415 | 0.9811 | 1.1392 | |
| HCC1187 | TNBC | Basal A | GSK1838705A | IGF1R | RTK | 7433.09 | uM | 1.91130 | 1.3970 | 0.4067 | 0.3957 | 4.9989 | 0.1848 | 0.9858 | 0.8477 |