Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HBL-100 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7429.074 | uM | 0.21399 | 0.25848 | -0.7951 | -0.7656 | 4.9167 | 0.8819 | 0.9981 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 7429.074 | uM | 0.21399 | 0.25848 | -0.7951 | -0.7656 | 4.9167 | 0.8819 | 0.9981 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7808.011 | uM | 91.64120 | 178.22410 | -0.9131 | -0.9831 | 1.6346 | 0.3085 | 0.9967 | 2.4301 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 7807.011 | uM | 80.29730 | 142.76360 | -0.7730 | -0.8163 | 1.6820 | 0.3238 | 0.9983 | 2.1620 | |
| HBL-100 | Unknown | Unknown | Carboplatin | DNA cross-linker | DNA cross-linker | 9226.021 | uM | 62.75020 | 112.42070 | -0.7415 | -0.7713 | 1.6005 | 0.3338 | 0.9996 | 2.5142 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7807.042 | uM | inf | inf | 1.0098 | 1.0098 | 0.0000 | -0.0392 | -7.7987 | 2.0250 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7808.052 | uM | inf | inf | 0.9944 | 0.9944 | 0.0000 | -0.0231 | -0.8225 | 2.4842 | |
| HBL-100 | Unknown | Unknown | Cetuximab | EGFR | ErbB | 7429.102 | uM | inf | 0.00269 | 0.9697 | 0.9727 | 4.9973 | 0.0039 | 0.6691 | 2.4347 | |
| HBL-100 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 9226.034 | uM | 747.89280 | 1000.00000 | -0.4886 | -0.3587 | 1.8615 | 0.2518 | 0.7818 | 2.6175 | ||
| HBL-100 | Unknown | Unknown | CGC-11047 | Polyamine analogue | 7808.052 | uM | inf | 0.72086 | 0.5882 | 0.6283 | 0.8496 | 0.1837 | 0.9560 | 2.4842 | ||
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7807.017 | uM | inf | inf | -0.4695 | -0.4695 | 0.0000 | 0.2218 | 0.4545 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 7808.017 | uM | 10.81030 | 17.89770 | -0.9142 | -0.9247 | 2.0769 | 0.3820 | 0.9981 | 2.4168 | |
| HBL-100 | Unknown | Unknown | Cisplatin | DNA cross-linker | DNA cross-linker | 9226.021 | uM | 8.73650 | 13.53040 | -0.6894 | -0.7018 | 2.0049 | 0.3883 | 0.9995 | 2.5142 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 7808.043 | uM | 3.95580 | 3.81630 | -0.1647 | 0.0821 | 5.0000 | 0.2428 | 0.8707 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 9226.034 | uM | 2.78310 | 4.5530 | -0.6561 | -0.6763 | 1.7380 | 0.3659 | 0.9993 | 2.6175 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 7807.002 | uM | 0.00197 | 0.00179 | 0.2403 | 0.1261 | 3.1066 | 0.6084 | 0.9293 | 2.1668 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 9226.002 | uM | 0.00159 | 0.00118 | 0.3255 | 0.2348 | 2.1218 | 0.5458 | 0.9405 | 2.4245 | |
| HBL-100 | Unknown | Unknown | Docetaxel | TUBB | TUBB | 7808.002 | uM | 0.00194 | 0.00155 | 0.3152 | 0.1983 | 2.2864 | 0.5513 | 0.9438 | 2.3302 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 7808.043 | uM | 0.03423 | 0.04488 | -0.2801 | -0.5530 | 2.7489 | 0.9385 | 0.9153 | 2.3907 | |
| HBL-100 | Unknown | Unknown | Doxorubicin | TOP2 | TOP | 9226.034 | uM | 0.06059 | 0.09525 | -0.8190 | -0.7193 | 1.9706 | 0.9033 | 0.9973 | 2.6175 | |
| HBL-100 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 7808.017 | uM | 0.11373 | 0.21830 | -0.9142 | -0.8609 | 1.5356 | 0.9503 | 0.9904 | 2.4168 | |
| HBL-100 | Unknown | Unknown | Epirubicin | TOP2 | TOP | 7807.017 | uM | 0.15688 | 0.25538 | -0.9194 | -0.8296 | 2.0074 | 0.9144 | 0.9978 | 2.2007 | |
| HBL-100 | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7429.09 | uM | inf | 76.97320 | 0.9353 | 0.8278 | 3.5846 | -0.0027 | 0.7593 | 2.2456 | |
| HBL-100 | Unknown | Unknown | Etoposide | TOP2 | TOP | 7429.074 | uM | 2.71640 | 5.26150 | -0.7559 | -0.7655 | 1.4047 | 0.5711 | 0.9988 | 2.3375 | |
| HBL-100 | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 7429.084 | uM | 0.51395 | 0.68198 | -0.7688 | -0.7596 | 3.2661 | 0.5289 | 0.9995 | 2.2510 |