Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7811.018 | uM | inf | inf | 0.6946 | 0.6946 | 0.0000 | 0.1308 | -0.0060 | 0.4694 | |
| HCC1187 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7812.042 | uM | inf | inf | 0.5614 | 0.5614 | 0.0000 | 0.0267 | 0.3674 | 0.9722 | |
| HCC1187 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 9244.034 | uM | 857.46960 | 1000.00000 | -0.9979 | -0.5786 | 5.0000 | 0.2889 | 0.5826 | 0.6294 | ||
| HCC1187 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7811.018 | uM | 26.10570 | 188.83540 | -0.9999 | -1.0000 | 0.5552 | 0.6062 | 0.8480 | 0.4694 | ||
| HCC1187 | TNBC | Basal A | Chk2 inhibitor II | CHK2 | CHK | 10518.14 | uM | inf | 9.15840 | 0.6700 | 0.6648 | 2.0740 | 0.0394 | 0.9522 | 1.2052 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7811.017 | uM | 1.68090 | 2.53690 | -1.0000 | -1.0000 | 2.6690 | 0.9047 | 0.7309 | 0.3604 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9244.021 | uM | 2.02180 | 2.59060 | -1.0000 | -0.9970 | 4.4235 | 0.7319 | 0.9785 | 0.4542 | |
| HCC1187 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7812.017 | uM | 3.44630 | 6.68930 | -0.9960 | -1.0000 | 1.6565 | 0.5582 | 0.9992 | 1.1362 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7812.047 | uM | 74.37790 | 78.0260 | 0.5106 | -0.1351 | 4.9941 | 0.0395 | 0.8794 | 1.0776 | |
| HCC1187 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 9244.034 | uM | 43.7880 | 54.54340 | -0.6387 | -0.9994 | 5.0000 | 0.1082 | 0.9651 | 0.6294 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 10753.146 | uM | inf | inf | 0.7845 | 0.7845 | 0.0000 | 0.1084 | 0.4052 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 13726.176 | uM | inf | inf | 0.6786 | 0.6786 | 0.0000 | 0.3517 | -0.3654 | 0.4071 | |
| HCC1187 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 12696.176 | uM | inf | inf | 0.6436 | 0.6436 | 0.0000 | 0.1782 | 0.0793 | 0.5469 | |
| HCC1187 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 12696.174 | uM | 0.11448 | 0.10972 | -0.2541 | 0.0957 | 4.9998 | 0.4914 | 0.7405 | 0.6299 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 9244.002 | uM | 0.00175 | 0.00410 | -0.9956 | -0.9809 | 1.2760 | 1.1697 | 0.9846 | 0.5206 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7812.002 | uM | 0.00215 | 0.00454 | -0.7983 | -0.7945 | 1.2771 | 1.0481 | 0.9866 | 1.0730 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 12696.002 | uM | 0.00173 | 0.00493 | -0.9723 | -0.9900 | 1.0427 | 1.1646 | 0.9945 | 0.7184 | |
| HCC1187 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7811.002 | uM | 0.00284 | 0.00560 | -0.9883 | -0.9948 | 1.6129 | 1.1674 | 0.9996 | 0.4929 | |
| HCC1187 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7812.047 | uM | 0.17722 | 0.19153 | -0.2867 | -0.2373 | 5.0000 | 0.5806 | 0.9903 | 1.0776 | |
| HCC1187 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 9244.034 | uM | 0.04058 | 0.09838 | -0.9997 | -1.0000 | 1.2406 | 1.0601 | 0.9910 | 0.6294 | |
| HCC1187 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7811.017 | uM | 0.08798 | 0.25888 | -1.0000 | -1.0000 | 1.0180 | 1.0515 | 0.9521 | 0.3604 | |
| HCC1187 | TNBC | Basal A | Epirubicin | TOP2 | TOP | 7812.017 | uM | 0.75055 | 0.92582 | -0.9987 | -0.9279 | 5.0000 | 0.8308 | 0.9913 | 1.1362 | |
| HCC1187 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7432.091 | uM | 5.14090 | 111.18440 | 0.0636 | -1.0000 | 0.3574 | 0.2772 | 0.9479 | 1.0227 | |
| HCC1187 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7433.09 | uM | 14.0570 | 12.42050 | 0.1979 | 0.1971 | 4.0485 | 0.0944 | 0.9674 | 0.8477 | |
| HCC1187 | TNBC | Basal A | Erlotinib | EGFR | ErbB | 7431.092 | uM | 10.43070 | 446.45670 | 0.3411 | -1.0000 | 0.2925 | 0.2014 | 0.9702 | 1.5006 |