Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10937.155 | uM | inf | inf | 0.7654 | 0.7654 | 0.0000 | 0.1268 | 0.4046 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10577.141 | uM | 8.0270 | 56.07330 | -0.0634 | -1.0000 | 0.5652 | 0.2508 | 0.9124 | 0.9203 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10937.153 | uM | 12.10530 | 19.95720 | -0.8966 | -1.0000 | 2.1975 | 0.2508 | 0.9836 | 1.5187 | |
| HCC3153 | TNBC | Basal A | Sirolimus | MTOR | MTOR | 7467.069 | uM | 5.13580 | 130.45920 | 0.0977 | -1.0000 | 0.3396 | 0.2294 | 0.8517 | 1.2461 | |
| HCC3153 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7466.085 | uM | inf | inf | -0.2970 | -0.2970 | 0.0000 | 0.1989 | 0.3303 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7467.084 | uM | 473.26120 | 596.4550 | -0.2513 | -0.5109 | 3.0429 | 0.1209 | 0.9856 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Sulindac sulfide | COX1/2 | COX | 10577.136 | uM | inf | inf | 0.8864 | 0.8864 | 0.0000 | 0.1425 | 0.2629 | 0.9962 | |
| HCC3153 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7467.067 | uM | 8.95180 | 12.07990 | -0.9776 | -0.9782 | 3.6170 | 0.4226 | 0.9972 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7466.067 | uM | 10.08160 | 13.52150 | -0.9915 | -0.9914 | 3.7228 | 0.3582 | 0.9977 | 0.9457 | |
| HCC3153 | TNBC | Basal A | TAPI-0 | TACE/Collagenase | 7466.096 | uM | inf | 0.27901 | 0.8129 | 0.8165 | 5.0000 | 0.0892 | 0.6063 | 0.9269 | ||
| HCC3153 | TNBC | Basal A | Taxol | TUBB | TUBB | 7853.002 | uM | inf | 0.02045 | 0.6746 | 0.6760 | 1.2679 | 0.1871 | 0.9889 | 2.9249 | |
| HCC3153 | TNBC | Basal A | Taxol | TUBB | TUBB | 10056.002 | uM | 0.01766 | 0.02353 | -0.4734 | -0.4586 | 2.2671 | 0.8140 | 0.9985 | 0.8731 | |
| HCC3153 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10577.14 | uM | 0.51320 | 0.79217 | -0.8743 | -0.8700 | 2.3219 | 0.5520 | 0.9984 | 0.9722 | |
| HCC3153 | TNBC | Basal A | TCS 2312 | CHK1 | CHK | 10937.152 | uM | 0.38525 | 0.53872 | -0.8103 | -0.8049 | 2.8609 | 0.5604 | 0.9987 | 1.2272 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10577.135 | uM | inf | inf | 0.6467 | 0.6467 | 0.0000 | 0.1256 | 0.4212 | 1.0749 | |
| HCC3153 | TNBC | Basal A | TCS PIM-1 1 | Pim kinase | PIM | 10937.148 | uM | inf | 15.70490 | 0.5912 | 0.5909 | 4.9618 | 0.0291 | 0.9388 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 10577.144 | uM | 26.10320 | 42.14550 | -0.9275 | -1.0000 | 2.2932 | 0.4588 | 0.6482 | 0.9534 | |
| HCC3153 | TNBC | Basal A | Temsirolimus | MTOR | MTOR | 10937.144 | uM | 26.07890 | 43.50640 | -0.8900 | -1.0000 | 2.1466 | 0.3620 | 0.8155 | 1.5466 | |
| HCC3153 | TNBC | Basal A | Topotecan | TOP1 | TOP | 7853.007 | uM | 0.23619 | 0.78837 | -0.7262 | -0.7964 | 0.7904 | 0.6950 | 0.9918 | 1.3351 | |
| HCC3153 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10937.15 | uM | 15.75670 | 29.68360 | -0.1024 | -1.0000 | 1.7347 | 0.1284 | 0.9444 | 1.3769 | |
| HCC3153 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10577.138 | uM | 21.55120 | 25.77270 | -0.7204 | -0.7223 | 4.9971 | 0.1693 | 0.9917 | 1.0408 | |
| HCC3153 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 7465.1 | uM | 14.61290 | 999.9780 | 0.2304 | -0.9567 | 0.2531 | 0.2764 | 0.9099 | 1.2603 | |
| HCC3153 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 10577.1 | uM | inf | 4.98380 | 0.5416 | 0.6152 | 4.9904 | 0.0699 | 0.9305 | 0.8774 | |
| HCC3153 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 7466.093 | uM | 12.72940 | 4.80290 | 0.4560 | 0.4527 | 2.4188 | 0.1219 | 0.9773 | 0.8543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 7853.036 | uM | inf | inf | 0.9191 | 0.9191 | 0.0000 | 0.0243 | 0.3415 | 1.4117 |