Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7465.087 | uM | 0.04939 | 0.14352 | -0.5310 | -0.4833 | 0.6340 | 0.6243 | 0.9871 | 1.1924 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 10577.087 | uM | 0.02859 | 0.16521 | -0.6730 | -0.7709 | 0.5318 | 0.7487 | 0.9909 | 0.9288 | |
| HCC3153 | TNBC | Basal A | Omipalisib | PI3K | PI3K | 7466.087 | uM | 0.03978 | 0.11243 | -0.5216 | -0.5276 | 0.6934 | 0.6732 | 0.9954 | 0.9127 | |
| HCC3153 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10056.021 | uM | 5.58260 | 20.4540 | -0.9069 | -1.0000 | 0.8461 | 0.5723 | 0.9822 | 0.8839 | |
| HCC3153 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7853.011 | uM | 9.18260 | 42.52990 | -0.7134 | -1.0000 | 0.7167 | 0.4650 | 0.9883 | 1.6331 | |
| HCC3153 | TNBC | Basal A | Oxamflatin | HDAC | HDAC | 10937.147 | uM | 1.66520 | 3.93510 | -0.9591 | -1.0000 | 1.2775 | 0.4482 | 0.9976 | 1.2614 | |
| HCC3153 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10937.152 | uM | inf | inf | 0.8382 | 0.8382 | 0.0000 | 0.0614 | 0.3121 | 1.2272 | |
| HCC3153 | TNBC | Basal A | PD 98059 | MEK | MAPK | 10577.136 | uM | 136.76730 | 1000.00000 | 0.4353 | -0.3602 | 0.2727 | 0.1740 | 0.7364 | 0.9962 | |
| HCC3153 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7465.1 | uM | 16.31040 | 106.92180 | 0.1370 | -1.0000 | 0.5843 | 0.2037 | 0.8529 | 1.2603 | |
| HCC3153 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 7466.093 | uM | 15.29620 | 32.19080 | -0.0284 | -1.0000 | 1.4765 | 0.1283 | 0.9755 | 0.8543 | |
| HCC3153 | TNBC | Basal A | PD173074 | FGFR1/3 | RTK | 10577.1 | uM | 20.79410 | 22.85870 | -0.2781 | -0.2857 | 4.7745 | 0.0752 | 0.9891 | 0.8774 | |
| HCC3153 | TNBC | Basal A | PD184352 | MEK | MAPK | 10937.155 | uM | inf | inf | 0.8699 | 0.8699 | 0.0000 | 0.0994 | 0.0000 | 1.3142 | |
| HCC3153 | TNBC | Basal A | PD184352 | MEK | MAPK | 10937.155 | uM | inf | inf | 0.8699 | 0.8699 | 0.0000 | 0.0994 | 0.0000 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7466.095 | uM | inf | inf | 1.0039 | 1.0039 | 0.0000 | -0.0104 | -0.0877 | 0.8699 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7465.095 | uM | inf | inf | 0.8393 | 0.8393 | 0.0000 | 0.1223 | -0.0252 | 1.2754 | |
| HCC3153 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7467.095 | uM | inf | 0.17682 | 0.6582 | 0.6600 | 5.0000 | 0.2517 | 0.9791 | 1.2671 | |
| HCC3153 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7467.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0386 | -3.7264 | 1.2393 | |
| HCC3153 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7466.065 | uM | inf | 999.98670 | 0.8529 | 0.7466 | 0.2221 | 0.0649 | 0.5788 | 0.8210 | |
| HCC3153 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7465.065 | uM | inf | 133.16390 | 0.8660 | 0.8650 | 2.1441 | 0.0311 | 0.6555 | 1.2013 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7466.067 | uM | inf | inf | 0.9484 | 0.9484 | 0.0000 | -0.0204 | 0.1276 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 7467.067 | uM | 261.60790 | 27.4740 | 0.5251 | 0.4555 | 1.0733 | 0.1070 | 0.9450 | 1.3252 | |
| HCC3153 | TNBC | Basal A | QNZ | NFkB | NFKB | 7466.096 | uM | 0.76630 | 0.03664 | 0.3984 | 0.4029 | 0.5392 | 0.3172 | 0.9597 | 0.9269 | |
| HCC3153 | TNBC | Basal A | Ro 32-0432 | PKC | PKC | 10577.142 | uM | inf | 0.00015 | 0.8665 | 0.8748 | 5.0000 | 0.1168 | 0.5822 | 1.0584 | |
| HCC3153 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 10577.144 | uM | inf | inf | 0.9200 | 0.9200 | 0.0000 | 0.0282 | 0.2113 | 0.9534 | |
| HCC3153 | TNBC | Basal A | SB-3CT | MMP2/9 | MMP | 10937.144 | uM | inf | 17.12360 | 0.8542 | 0.8541 | 4.9969 | 0.0238 | 0.6766 | 1.5466 |