Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Mebendazole | 12939.174 | uM | 0.09935 | 0.55943 | -0.8642 | -0.9370 | 0.6109 | 0.7618 | 0.9574 | 0.3466 | |||
| HCC3153 | TNBC | Basal A | Mebendazole | 13583.174 | uM | 0.16580 | 0.26708 | -0.6804 | -0.5978 | 1.6495 | 0.6918 | 0.9714 | 0.3654 | |||
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7466.085 | uM | inf | inf | 0.9627 | 0.9627 | 0.0000 | 0.0395 | 0.1367 | 0.8684 | |
| HCC3153 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 7467.084 | uM | inf | 0.03588 | 0.6430 | 0.6163 | 5.0000 | 0.2732 | 0.9561 | 1.3029 | |
| HCC3153 | TNBC | Basal A | Methylglyoxal | 13603.184 | uM | 29.55980 | 192.7650 | -0.9947 | -1.0000 | 0.5859 | 0.9435 | 0.9105 | 0.7451 | |||
| HCC3153 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14131.189 | uM | 0.15568 | 0.17557 | -0.9362 | -0.4119 | 5.0000 | 0.7255 | 0.6239 | 1.2288 | |
| HCC3153 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 14131.189 | uM | 0.15568 | 0.17557 | -0.9362 | -0.4119 | 5.0000 | 0.7255 | 0.6239 | 1.2288 | |
| HCC3153 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 10577.145 | uM | 0.16260 | 0.21708 | -0.9699 | -0.9684 | 3.7276 | 0.8980 | 0.9970 | 0.9676 | |
| HCC3153 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 10577.145 | uM | 0.16260 | 0.21708 | -0.9699 | -0.9684 | 3.7276 | 0.8980 | 0.9970 | 0.9676 | |
| HCC3153 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 10937.145 | uM | 0.09992 | 0.14032 | -0.9691 | -0.9620 | 3.1600 | 0.9354 | 0.9998 | 1.2098 | |
| HCC3153 | TNBC | Basal A | MG-132 | Proteasome | Proteasome | 10937.145 | uM | 0.09992 | 0.14032 | -0.9691 | -0.9620 | 3.1600 | 0.9354 | 0.9998 | 1.2098 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 10577.135 | uM | 0.49792 | 1.43970 | -0.5825 | -0.6584 | 0.7914 | 0.5413 | 0.9731 | 1.0749 | |
| HCC3153 | TNBC | Basal A | Pevonedistat | NAE1 | NAE1 | 10937.148 | uM | 0.22673 | 0.34167 | -0.4268 | -0.3439 | 1.2763 | 0.5453 | 0.9914 | 1.4600 | |
| HCC3153 | TNBC | Basal A | Nelfinavir | 13733.174 | uM | 6.79860 | 9.17240 | -0.9963 | -1.0000 | 3.6683 | 0.3309 | 0.9153 | 0.5093 | |||
| HCC3153 | TNBC | Basal A | Nelfinavir | 12939.174 | uM | 2.09890 | 5.54180 | -0.9996 | -1.0000 | 1.1315 | 0.4041 | 0.9209 | 0.3466 | |||
| HCC3153 | TNBC | Basal A | Nelfinavir | 13583.174 | uM | 6.17610 | 7.69370 | -1.0000 | -1.0000 | 5.0000 | 0.2044 | 0.9928 | 0.3654 | |||
| HCC3153 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10937.145 | uM | inf | inf | 1.0433 | 1.0433 | 0.0000 | 0.0136 | 0.0664 | 1.2098 | |
| HCC3153 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10577.145 | uM | inf | 42.00360 | 0.5069 | 0.5067 | 5.0000 | 0.0778 | 0.8731 | 0.9676 | |
| HCC3153 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10937.152 | uM | 1.82810 | 2.86270 | -0.9740 | -0.9703 | 2.4048 | 0.6175 | 0.9980 | 1.2272 | |
| HCC3153 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10577.14 | uM | 2.4650 | 3.61860 | -0.9817 | -0.9832 | 2.8326 | 0.5933 | 0.9991 | 0.9722 | |
| HCC3153 | TNBC | Basal A | NU6102 | CDK1/2 | CDK | 10937.147 | uM | 16.94970 | 21.36330 | -0.4976 | -0.5386 | 3.1588 | 0.1309 | 0.9940 | 1.2614 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7465.066 | uM | 32.33410 | 65.23290 | -0.0204 | -1.0000 | 1.5653 | 0.1316 | 0.9304 | 1.2627 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7466.066 | uM | 42.15690 | 43.02170 | 0.1633 | -0.0345 | 3.2879 | 0.0160 | 0.9771 | 0.9420 | |
| HCC3153 | TNBC | Basal A | Nutlin 3a | MDM2 | MDM2 | 7467.066 | uM | 28.84520 | 47.81640 | -0.3469 | -1.0000 | 2.1736 | 0.1248 | 0.9908 | 1.1956 | |
| HCC3153 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 10937.147 | uM | 3.51070 | 7.18610 | -0.8865 | -0.9411 | 1.4778 | 0.4363 | 0.9962 | 1.2614 |