Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | ICRF-193 | TOP2 | TOP | 10694.151 | uM | inf | 0.53033 | 0.5289 | 0.5954 | 1.6828 | 0.1348 | 0.9415 | 2.4341 | |
| Hs 578T | TNBC | Basal B | IKK16 | IKK | NFKB | 7472.1 | uM | 5.06940 | 6.31580 | -0.9972 | -0.9998 | 4.9971 | 0.3359 | 0.9967 | 1.1120 | |
| Hs 578T | TNBC | Basal B | IKK16 | IKK | NFKB | 10379.093 | uM | 3.03290 | 3.64260 | -0.7349 | -0.7364 | 4.9427 | 0.3496 | 0.9989 | 2.2706 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7471.092 | uM | 3.33160 | 4.13810 | -1.0000 | -0.9781 | 5.0000 | 0.8415 | 0.9628 | 0.3860 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7472.092 | uM | 43.19490 | 53.80930 | -0.9934 | -1.0000 | 5.0000 | 0.3777 | 0.9852 | 1.2676 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 10379.092 | uM | 26.20820 | 36.22250 | -0.6938 | -0.7029 | 2.7127 | 0.4054 | 0.9918 | 2.5811 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7475.091 | uM | 45.47120 | 55.68670 | -0.8516 | -0.8773 | 4.9999 | 0.3111 | 0.9966 | 2.6839 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7473.091 | uM | 47.79080 | 58.95690 | -0.9154 | -0.9286 | 5.0000 | 0.3131 | 0.9966 | 2.3297 | |
| Hs 578T | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7474.09 | uM | 48.78950 | 59.97360 | -0.8920 | -0.9033 | 5.0000 | 0.3121 | 0.9970 | 2.4405 | |
| Hs 578T | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7474.067 | uM | 0.31532 | 3.31190 | -0.8618 | -1.0000 | 0.4672 | 0.4288 | 0.8504 | 2.7442 | |
| Hs 578T | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7473.067 | uM | 0.93986 | 5.19730 | -0.8838 | -1.0000 | 0.6424 | 0.3695 | 0.8768 | 2.6736 | |
| Hs 578T | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7475.067 | uM | 0.71073 | 4.54110 | -0.8808 | -1.0000 | 0.5924 | 0.4012 | 0.8779 | 2.4078 | |
| Hs 578T | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7475.095 | uM | 0.35062 | 8.65170 | -0.8990 | -1.0000 | 0.3427 | 0.4290 | 0.5973 | 2.2334 | |
| Hs 578T | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7474.095 | uM | 0.01553 | 1.38430 | -0.8363 | -1.0000 | 0.2447 | 0.6678 | 0.6977 | 2.8423 | |
| Hs 578T | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7472.095 | uM | 0.03066 | 1.09650 | -0.8636 | -1.0000 | 0.3071 | 0.6433 | 0.8188 | 2.5356 | |
| Hs 578T | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7473.095 | uM | 0.00207 | 0.00228 | -0.5912 | -0.0852 | 1.6663 | 0.7858 | 0.8309 | 3.1412 | |
| Hs 578T | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 10379.095 | uM | 0.00262 | 0.00403 | -0.8805 | -0.2914 | 1.0639 | 0.8716 | 0.8375 | 2.3292 | |
| Hs 578T | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7471.095 | uM | 0.00239 | 0.00418 | -0.8602 | -0.3485 | 0.9488 | 0.9165 | 0.8715 | 2.3069 | |
| Hs 578T | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 10694.144 | uM | 0.63483 | 0.63662 | -0.1775 | -0.0071 | 5.0000 | 0.3929 | 0.9739 | 2.1636 | |
| Hs 578T | TNBC | Basal B | L-779450 | BRAF | MAPK | 10694.149 | uM | 24.23710 | 50.62480 | 0.3024 | -1.0000 | 1.4916 | 0.0641 | 0.9910 | 2.3563 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7472.098 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0197 | -0.2479 | 1.5098 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7473.098 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0193 | -0.2353 | 2.2810 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7475.098 | uM | inf | inf | 1.0092 | 1.0092 | 0.0000 | -0.0133 | -0.1678 | 2.2876 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7474.098 | uM | inf | inf | 1.0223 | 1.0223 | 0.0000 | -0.0080 | -0.0536 | 2.6093 | |
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7471.098 | uM | inf | 1000.00000 | 0.8725 | 0.5265 | 0.2800 | 0.0398 | 0.6462 | 2.2704 |