Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9583.011 | uM | 8.00340 | 48.93110 | -0.7284 | -1.0000 | 0.6068 | 0.4425 | 0.9666 | 1.0421 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10073.021 | uM | 3.60080 | 21.76430 | -0.9226 | -1.0000 | 0.6106 | 0.5358 | 0.9730 | 0.5665 | |
| MCF7 | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7875.011 | uM | 4.64770 | 37.25340 | -0.6858 | -1.0000 | 0.5278 | 0.5100 | 0.9736 | 1.6960 | |
| MCF7 | HR+ | Luminal | Oxamflatin | HDAC | HDAC | 10997.147 | uM | 2.0430 | 3.35620 | -0.5780 | -0.6235 | 1.6311 | 0.4268 | 0.9791 | 1.3792 | |
| MCF7 | HR+ | Luminal | PD 98059 | MEK | MAPK | 10997.152 | uM | inf | inf | 0.9662 | 0.9662 | 0.0000 | 0.0421 | -0.1931 | 1.3917 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 10997.155 | uM | inf | inf | 0.9516 | 0.9516 | 0.0000 | -0.0284 | -0.8847 | 1.3159 | |
| MCF7 | HR+ | Luminal | PD184352 | MEK | MAPK | 10997.155 | uM | inf | inf | 0.9516 | 0.9516 | 0.0000 | -0.0284 | -0.8847 | 1.3159 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7492.095 | uM | inf | inf | 0.7935 | 0.7935 | 0.0000 | 0.2394 | -0.1467 | 1.0194 | |
| MCF7 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7493.095 | uM | inf | 0.72707 | 0.6037 | 0.5948 | 1.8330 | 0.2708 | 0.8682 | 1.0092 | |
| MCF7 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7492.065 | uM | inf | inf | 0.9681 | 0.9681 | 0.0000 | 0.0052 | 0.0000 | 1.6050 | |
| MCF7 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7493.065 | uM | inf | inf | 0.9657 | 0.9657 | 0.0000 | 0.0334 | 0.0768 | 1.2680 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7493.067 | uM | inf | inf | 0.9222 | 0.9222 | 0.0000 | 0.0803 | 0.0000 | 1.3684 | |
| MCF7 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7492.067 | uM | 13.90360 | 16.48540 | -0.1902 | -0.2018 | 1.9903 | 0.2555 | 0.9794 | 1.4243 | |
| MCF7 | HR+ | Luminal | QNZ | NFkB | NFKB | 7493.096 | uM | 0.32098 | 0.16615 | 0.1642 | 0.1372 | 0.4872 | 0.3625 | 0.9567 | 1.1669 | |
| MCF7 | HR+ | Luminal | Ribavirin | 15394.211 | uM | inf | 11.26250 | 0.5083 | 0.5081 | 4.9999 | 0.0487 | 0.9495 | 1.8299 | |||
| MCF7 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10997.144 | uM | inf | inf | 0.8715 | 0.8715 | 0.0000 | 0.0016 | 0.4933 | 1.2750 | |
| MCF7 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10997.155 | uM | inf | inf | 0.9524 | 0.9524 | 0.0000 | -0.0139 | 0.0569 | 1.3159 | |
| MCF7 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10997.153 | uM | 1.66070 | 4.34240 | -0.9658 | -1.0000 | 1.1430 | 0.4990 | 0.9842 | 1.0771 | |
| MCF7 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7492.069 | uM | 0.46777 | 0.02741 | 0.3290 | 0.3589 | 0.4460 | 0.3438 | 0.9755 | 1.7373 | |
| MCF7 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7492.084 | uM | 61.92850 | 48.41620 | 0.2562 | 0.3540 | 5.0000 | 0.1791 | 0.9273 | 1.4850 | |
| MCF7 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7493.085 | uM | 64.21010 | 131.75390 | -0.6152 | -1.0000 | 1.5284 | 0.1784 | 0.9965 | 1.4204 | |
| MCF7 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7493.067 | uM | 6.11730 | 7.60750 | -0.9706 | -0.9584 | 4.9100 | 0.4638 | 0.9935 | 1.3684 | |
| MCF7 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7492.067 | uM | 6.15920 | 9.14260 | -0.9677 | -0.9805 | 2.7482 | 0.4584 | 0.9975 | 1.4243 | |
| MCF7 | HR+ | Luminal | TAPI-0 | TACE/Collagenase | 7493.096 | uM | 257.88420 | 999.83190 | 0.6802 | -0.3021 | 0.3488 | 0.0824 | 0.8923 | 1.1669 | ||
| MCF7 | HR+ | Luminal | Taxol | TUBB | TUBB | 10073.002 | uM | 0.01868 | 0.01258 | 0.1344 | 0.2295 | 1.5541 | 0.4573 | 0.9791 | 0.7762 |